Search
Results: 847
Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila.
We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated. These muscles revealed new functions for IAPs not required...
D. melanogaster Actin Cytoskeleton Cell Biology cell-ECM adhesion developmental biology filamin integrin myotendinous junction Vinculin Actins Animals Drosophila Proteins Drosophila melanogaster Epistasis Genetic Flight Animal Integrins Muscles Mutation Myofibrils Phenotype RNA Interference Sarcomeres Vinculin
Neutrophil GM-CSF receptor dynamics in acute lung injury.
Silvia De Alessandris, G John Ferguson, Alison J Dodd, Jatinder K Juss, Abhinandan Devaprasad, Siân Piper, Owen Wyatt, Helen Killick, Dominic J Corkill, E Suzanne Cohen, Aridaman Pandit, Timothy RDJ Radstake, Rosalind Simmonds, Alison M Condliffe, Matthew A Sleeman, Andrew S Cowburn, Donna K Finch, Edwin R Chilvers
May 07, 2019
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process...
LPS Alveolar Apoptosis Inflammation signaling Acute Lung Injury Adult Animals Cell Line Tumor Cytokine Receptor Common beta Subunit Disease Models Animal Female Gene Expression Regulation Humans Lipopolysaccharides Male Mice Mice Inbred BALB C Mice Transgenic Neutrophils Pulmonary Alveoli Receptors Granulocyte-Macrophage Colony-Stimulating Factor Time Factors
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Tomas Castro-Dopico, Aaron Fleming, Thomas W Dennison, John R Ferdinand, Katherine Harcourt, Benjamin J Stewart, Zaeem Cader, Zewen K Tuong, Chenzhi Jing, Laurence SC Lok, Rebeccah J Mathews, Anaïs Portet, Arthur Kaser, Simon Clare, Menna R Clatworthy
Jun 16, 2020
Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as...
GM-CSF anti-microbial defense Crosstalk inflammatory bowel disease innate lymphoid cells MACROPHAGES Wound Healing Animals Cell Polarity Citrobacter rodentium Colitis Enterobacteriaceae Infections Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunity Innate Inflammation Intestines Lymphocytes Macrophage Activation MACROPHAGES Mice Inbred C57BL Phenotype Wound Healing
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo CP van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre MJJ Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Jul 06, 2020
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF...
Bandwidth Estimation and Optimized Bitrate Selection for Dynamic Adaptive Streaming Over HTTP Using RSI-GM and ISSO
Dynamic Adaptive Streaming over HTTP (DASH) is an emerging solution that aims to standardize existing proprietary streaming systems. DASH specification defines the media presentation description (MPD), which describes a list of...
Computer Vision & Image Processing Computer Science and Information Technology Computer Vision and Machine Perception
Published by: IGI Global Scientific Publishing
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E Schwab, Zainab Shahid, Michinori Shirano, Julia E Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Nov 16, 2022
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre...
The basal ganglia in perceptual timing
The timing of perceptual events depends on an anatomically and functionally connected network comprising basal ganglia, cerebellum, pre-frontal cortex and supplementary motor area. Recent studies demonstrate the cerebellum to be...
THE SUBJECT OF SOVEREIGNTY
Abstract Hugo Grotius’s account of sovereign power inDe iure belli ac pacis occupies a contested place in recent genealogies of modern sovereignty. This article takes a...
Annabel Brett
Feb 08, 2019
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera, John T. O’Brien
Apr 24, 2021
Abstract: Background: Structural brain changes associated with Alzheimer’s disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be...
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W Ritchie, Li Su, Graciela Muniz-Terrera, John T O'Brien
Dec 23, 2020
BACKGROUND: Structural brain changes associated with Alzheimer's disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated...
Delirium in the acute hospital setting
In this overview we discuss the role of psychiatry in managing delirium in acute hospital admissions. We briefly discuss the role psychiatry can offer in four main domains: (a) assessment; (b) management; (c) recovery; and (d)...
The viscoelastic response of electrospun poly(vinyl alcohol) mats.
Native biological tissues are viscoelastic materials that undergo time-dependent loading in vivo. It is therefore crucial to ensure that biomedical materials have a suitable viscoelastic response for a given application. In this...
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Richard P Hayhoe, Cristin G Print, Simon J Cook, Edwin R Chilvers
Jun 19, 2018
Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis...
Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Caspase 9 Cell Survival Gene Expression Regulation Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Inflammation Membrane Proteins Microscopy Confocal Models Biological Neutrophils Phenotype Pneumonia Proto-Oncogene Proteins Tumor Necrosis Factor-alpha
Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation
Puja Mehta, Joanna C Porter, Jessica J Manson, John D Isaacs, Peter JM Openshaw, Iain B McInnes, Charlotte Summers, Rachel C Chambers
Jun 11, 2020
The COVID-19 pandemic is a global public health crisis, with considerable mortality and morbidity exerting pressure on health-care resources, including critical care. An excessive host inflammatory response in a subgroup of...
Balancing Interests in Forest Governance in Brazil and Indonesia
Annabel McCormick Baldy
Jan 01, 0001
Forests play a major role in reducing levels of Greenhouse gasses which are a major contributor to global warming. Conversely, deforestation is a major contributor to climate change. This study examines the concept of good...
forest governance Elinor Ostrom Deforestation indigenous people and local communities common resources agribusiness Agricultural Economics Environmental Studies Forest management International Relations Natural Resources and Conservation
Published by: Ursinus College
rpsftm
Treatment switching in a randomised controlled trial occurs when participants change from their randomised treatment to the other trial treatment during the study. Failure to account for treatment switching in the analysis (i.e....
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Sep 30, 2020
Abstract: Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is...
Gray matter changes related to microglial activation in Alzheimer's disease.
Nicolas Nicastro, Maura Malpetti, Elijah Mak, Guy B Williams, W Richard Bevan-Jones, Stephen F Carter, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Jun 12, 2020
Neuroinflammation is increasingly recognized as playing a key pathogenetic role in Alzheimer's disease (AD). We examined the relationship between in vivo neuroinflammation and gray matter (GM) changes. Twenty-eight subjects with...
Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts.
Kristine B Walhovd, Anders M Fjell, Yunpeng Wang, Inge K Amlien, Athanasia M Mowinckel, Ulman Lindenberger, Sandra Düzel, David Bartrés-Faz, Klaus P Ebmeier, Christian A Drevon, William FC Baaré, Paolo Ghisletta, Louise Baruël Johansen, Rogier A Kievit, Richard N Henson, Kathrine Skak Madsen, Lars Nyberg, Jennifer R Harris, Cristina Solé-Padullés, Sara Pudas, Øystein Sørensen, René Westerhausen, Enikő Zsoldos, Laura Nawijn, Torkild Hovde Lyngstad, Sana Suri, Brenda Penninx, Ole J Rogeberg, Andreas M Brandmaier
Sep 20, 2021
Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability differ across cohorts, by age...
A Sweet Galactose Transfer
The introduction of chemical reporter groups into glycan structures through metabolic oligosaccharide engineering (MOE) followed by bio-orthogonal ligation is an important tool to study glycosylation. We show the incorporation...
Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds.
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Jul 07, 2021
Abstract: Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is...
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
The developmental origin of dendritic cells, a specialized system of major histocompatibility complex (MHC) class II-rich antigen-presenting cells for T-cell immunity and tolerance, is not well characterized....
bone marrow cell cell granule cellular immunity dendritic cell granulocyte macrophage mixed lymphocyte reaction stem cell
Published by: Rockefeller University
|
|< |
< |
1 |