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Results: 18777
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Natural Biomaterials for Cardiac Tissue Engineering
Qasim A. Majid, Annabelle T. R. Fricker, David A. Gregory, Natalia Davidenko, Olivia Hernandez Cruz, Richard J. Jabbour, Thomas J. Owen, Pooja Basnett, Barbara Lukasiewicz, Molly Stevens, Serena Best, Ruth Cameron, Sanjay Sinha, Sian E. Harding, Ipsita Roy
Nov 09, 2020
Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial...
TRANCE, a tumor necrosis factor family member critical for CD40 ligand- independent T helper cell activation
CD40 ligand (CD40L), a tumor necrosis factor (TNF) family member, plays a critical role in antigen-specific T cell responses in vivo. CD40L expressed on activated CD4+ T cells stimulates antigen-presenting cells such as...
CD40 antigen tumor necrosis factor dendritic cell Ligand binding immune response receptor upregulation t lymphocyte activation virus cell interaction Spleen
Published by: Rockefeller University
A farewell to <i>R</i>
The time-dependent reproduction number, Rt, is a key metric used by epidemiologists to assess the current state of an outbreak of an infectious disease. This quantity is usually estimated using...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
TRANCE (Tumor necrosis factor [TNF]-related Activation-induced Cytokine), a new TNF family member predominantly expressed in t cells, is a dendritic cell-specific survival factor
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after interaction with its...
cytokine tumor necrosis factor lymphocyte proliferation dendritic cell protein determination T lymphocyte
Published by: Rockefeller University
Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers
Undertaking a high volume of physical activity is associated with reduced risk of a broad range of clinically diagnosed cancers. These findings, which imply that physical activity induces physiological changes that avert or...
Cancer Exercise exercise immunology exercise oncology physical activity /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers
Undertaking a high volume of physical activity is associated with reduced risk of a broad range of clinically diagnosed cancers. These findings, which imply that physical activity induces physiological changes that avert or...
Cancer Exercise exercise immunology exercise oncology physical activity /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
A Novel Framework Using Zero Shot Learning Technique for a Non-Factoid Question Answering System
Non-Factoid Question Answering (QA) is the next generation of textual QA systems, which gives passage level summaries for a natural language query, posted by the user. The main issue lies in the appropriateness of the generated...
Published by: IGI Global Scientific Publishing
Mining Competitors and Finding Winning Plans Using Feature Scoring and Ranking-Based CMiner++ Algorithm
For a business to succeed, it is very important to make things speaking more to clients than to rivals. It is more critical to decide on the significant feature of an item which influences its competency. In spite of the works...
Published by: IGI Global Scientific Publishing
Torus bundles, automorphisms and T-duality
Abstract: We reconsider some older constructions of T-duality, based on automorphisms of the worldsheet operator algebra, in a modern context. It has been long known that at special points in the moduli space of torus...
Natural Biomaterials for Cardiac Tissue Engineering
Qasim A Majid, Annabelle TR Fricker, David A Gregory, Natalia Davidenko, Olivia Hernandez Cruz, Richard J Jabbour, Thomas J Owen, Pooja Basnett, Barbara Lukasiewicz, Molly Stevens, Serena Best, Ruth Cameron, Sanjay Sinha, Sian E Harding, Ipsita Roy
Nov 23, 2020
Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial...
Torus bundles, automorphisms and T-duality
Abstract: We reconsider some older constructions of T-duality, based on automorphisms of the worldsheet operator algebra, in a modern context. It has been long known that at special points in the moduli space of torus...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park, Rachel A Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, Kenny Roberts, Veronika R Kedlian, John R Ferdinand, Xiaoling He, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa T Mahbubani, Krzysztof Polanski, Lira Mamanova, Liam Bolt, David Crossland, Fabrizio de Rita, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Omer A Bayraktar, Roger A Barker, Kerstin B Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A Teichmann
Mar 19, 2020
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell...
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV
A Abulencia, D Acosta, J Adelman, T Affolder, T Akimoto, MG Albrow, D Ambrose, S Amerio, D Amidei, A Anastassov, K Anikeev, A Annovi, J Antos, M Aoki, G Apollinari, JF Arguin, T Arisawa, A Artikov, W Ashmanskas, A Attal, F Azfar, P Azzi-Bacchetta, P Azzurri, N Bacchetta, H Bachacou, W Badgett, A Barbaro-Galtieri, VE Barnes, BA Barnett, S Baroiant, V Bartsch, G Bauer, F Bedeschi, S Behari, S Belforte, G Bellettini, J Bellinger, A Belloni, E Ben Haim, D Benjamin, A Beretvas, J Beringer, T Berry, A Bhatti, M Binkley, D Bisello, RE Blair, C Blocker, B Blumenfeld, A Bocci, A Bodek, V Boisvert, G Bolla, A Bolshov, D Bortoletto, J Boudreau, A Boveia, B Brau, C Bromberg, E Brubaker, J Budagov, HS Budd, S Budd, K Burkett, G Busetto, P Bussey, KL Byrum, S Cabrera, M Campanelli, M Campbell, F Canelli, A Canepa, D Carlsmith, R Carosi, S Carron, M Casarsa, A Castro, P Catastini, D Cauz, M Cavalli-Sforza, A Cerri, L Cerrito, SH Chang, J Chapman, YC Chen, M Chertok, G Chiarelli, G Chlachidze, F Chlebana, I Cho, K Cho, D Chokheli, JP Chou, PH Chu, SH Chuang, K Chung, WH Chung, YS Chung, M Ciljak, CI Ciobanu, MA Ciocci, A Clark, D Clark, M Coca, G Compostella, ME Convery, J Conway, B Cooper, K Copic, M Cordelli, G Cortiana, F Cresciolo, A Cruz, CC Almenar, J Cuevas, R Culbertson, D Cyr, S DaRonco, S D'Auria, M D'Onofrio, D Dagenhart, P de Barbaro, S De Cecco, A Deisher, G De Lentdecker, M Dell'Orso, FD Paoli, S Demers, L Demortier, J Deng, M Deninno, D De Pedis, PF Derwent, C Dionisi, JR Dittmann, P DiTuro, C Dorr, S Donati, M Donega, P Dong, J Donini, T Dorigo, S Dube, K Ebina, J Efron, J Ehlers, R Erbacher, D Errede, S Errede, R Eusebi, HC Fang, S Farrington, I Fedorko, WT Fedorko, RG Feild, M Feindt, JP Fernandez, R Field, G Flanagan, LR Flores-Castillo, A Foland, S Forrester, GW Foster, M Franklin, JC Freeman, I Furic, M Gallinaro, J Galyardt, JE Garcia, MG Sciveres, AF Garfinkel, C Gay, H Gerberich, D Gerdes, S Giagu, P Giannetti, A Gibson, K Gibson, C Ginsburg, N Giokaris, K Giolo, M Giordani, P Giromini, M Giunta, G Giurgiu, V Glagolev, D Glenzinski, M Gold, N Goldschmidt, J Goldstein, G Gomez, G Gomez-Ceballos, M Goncharov, O Gonzalez, I Gorelov, AT Goshaw, Y Gotra, K Goulianos, A Gresele, M Griffiths, S Grinstein, C Grosso-Pilcher, RC Group, U Grundler, JG da Costa, Z Gunay-Unalan, C Haber, SR Hahn, K Hahn, E Halkiadakis, A Hamilton, BY Han, JY Han, R Handler, F Happacher, K Hara, M Hare, S Harper, RF Harr, RM Harris, K Hatakeyama, J Hauser, C Hays, A Heijboer, B Heinemann, J Heinrich, M Herndon, D Hidas, CS Hill, D Hirschbuehl, A Hocker, A Holloway, S Hou, M Houlden, SC Hsu, BT Huffman, RE Hughes, J Huston, J Incandela, G Introzzi, M Iori, Y Ishizawa, A Ivanov, B Iyutin, E James, D Jang, B Jayatilaka, D Jeans, H Jensen, EJ Jeon, S Jindariani, M Jones, KK Joo, SY Jun, TR Junk, T Kamon, J Kang, PE Karchin, Y Kato, Y Kemp, R Kephart, U Kerzel, V Khotilovich, B Kilminster, DH Kim, HS Kim, JE Kim, MJ Kim, SB Kim, SH Kim, YK Kim, L Kirsch, S Klimenko, M Klute, B Knuteson, BR Ko, H Kobayashi, K Kondo, DJ Kong, J Konigsberg, A Korytov, AV Kotwal, A Kovalev, A Kraan, J Kraus, I Kravchenko, M Kreps, J Kroll, N Krumnack, M Kruse, V Krutelyov, SE Kuhlmann, Y Kusakabe, S Kwang, AT Laasanen, S Lai, S Lami, S Lammel, M Lancaster, RL Lander, K Lannon, A Lath, G Latino, I Lazzizzera, T LeCompte, J Lee, J Lee, YJ Lee, SW Lee, R Lefevre, N Leonardo, S Leone, S Levy, JD Lewis, C Lin, CS Lin, M Lindgren, E Lipeles, TM Liss, A Lister, DO Litvintsev, T Liu, NS Lockyer, A Loginov, M Loreti, P Loverre, RS Lu, D Lucchesi, P Lujan, P Lukens, G Lungu, L Lyons, J Lys, R Lysak, E Lytken, P Mack, D MacQueen, R Madrak, K Maeshima, T Maki, P Maksimovic, S Malde, G Manca, F Margaroli, R Marginean, C Marino, A Martin, V Martin, M Martinez, T Maruyama, P Mastrandrea, H Matsunaga, ME Mattson, R Mazini, P Mazzanti, KS McFarland, M McFarlane, P McIntyre, R McNulty, A Mehta, S Menzemer, A Menzione, P Merkel, C Mesropian, A Messina, M von der Mey, T Miao, N Miladinovic, J Miles, R Miller, JS Miller, C Mills, M Milnik, R Miquel, A Mitra, G Mitselmakher, A Miyamoto, N Moggi, B Mohr, R Moore, M Morello, PM Fernandez, J Mulmenstadt, A Mukherjee, T Muller, R Mumford, P Murat, J Nachtman, J Naganoma, S Nahn, I Nakano, A Napier, D Naumov, V Necula, C Neu, MS Neubauer, J Nielsen, T Nigmanov, L Nodulman, O Norniella, E Nurse, T Ogawa, SH Oh, YD Oh, T Okusawa, R Oldeman, R Orava, K Osterberg, C Pagliarone, E Palencia, R Paoletti, V Papadimitriou, AA Paramonov, B Parks, S Pashapour, J Patrick, G Pauletta, M Paulini, C Paus, DE Pellett, A Penzo, TJ Phillips, G Piacentino, J Piedra, L Pinera, K Pitts, C Plager, L Pondrom, X Portell, O Poukhov, N Pounder, F Prakoshyn, A Pronko, J Proudfoot, F Ptohos, G Punzi, J Pursley, J Rademacker, A Rahaman, A Rakitin, S Rappoccio, F Ratnikov, B Reisert, V Rekovic, N van Remortel, P Renton, M Rescigno, S Richter, F Rimondi, L Ristori, WJ Robertson, A Robson, T Rodrigo, E Rogers, S Rolli, R Roser, M Rossi, R Rossin, C Rott, A Ruiz, J Russ, V Rusu, H Saarikko, S Sabik, A Safonov, WK Sakumoto, G Salamanna, O Salto, D Saltzberg, C Sanchez, L Santi, S Sarkar, L Sartori, K Sato, P Savard, A Savoy-Navarro, T Scheidle, P Schlabach, EE Schmidt, P Schmidt, M Schmitt, T Schwarz, L Scodellaro, AL Scott, A Scribano, F Scuri, A Sedov, S Seidel, Y Seiya, A Semenov, L Sexton-Kennedy, I Sfiligoi, MD Shapiro, T Shears, PF Shepard, D Sherman, M Shimojima, M Shochet, Y Shon, I Shreyber, A Sidoti, P Sinervo, A Sisakyan, J Sjolin, A Skiba, AJ Slaughter, K Sliwa, JR Smith, FD Snider, R Snihur, M Soderberg, A Soha, S Somalwar, V Sorin, J Spalding, M Spezziga, F Spinella, T Spreitzer, P Squillacioti, M Stanitzki, A Staveris-Polykalas, RS Denis, B Stelzer, O Stelzer-Chilton, D Stentz, J Strologas, D Stuart, JS Suh, A Sukhanov, K Sumorok, H Sun, T Suzuki, A Taffard, R Takashima, Y Takeuchi, K Takikawa, M Tanaka, R Tanaka, N Tanimoto, M Tecchio, PK Teng, K Terashi, S Tether, J Thom, AS Thompson, E Thomson, P Tipton, V Tiwari, S Tkaczyk, D Toback, S Tokar, K Tollefson, T Tomura, D Tonelli, M Tonnesmann, S Torre, D Torretta, S Tourneur, W Trischuk, R Tsuchiya, S Tsuno, N Turini, F Ukegawa, T Unverhau, S Uozumi, D Usynin, A Vaiciulis, S Vallecorsa, A Varganov, E Vataga, G Velev, G Veramendi, V Veszpremi, R Vidal, I Vila, R Vilar, T Vine, I Vollrath, I Volobouev, G Volpi, F Wurthwein, P Wagner, RG Wagner, RL Wagner, W Wagner, R Wallny, T Walter, Z Wan, SM Wang, A Warburton, S Waschke, D Waters, WC Wester, B Whitehouse, D Whiteson, AB Wicklund, E Wicklund, G Williams, HH Williams, P Wilson, BL Winer, P Wittich, S Wolbers, C Wolfe, T Wright, X Wu, SM Wynne, A Yagil, K Yamamoto, J Yamaoka, T Yamashita, C Yang, UK Yang, YC Yang, WM Yao, GP Yeh, J Yoh, K Yorita, T Yoshida, GB Yu, I Yu, SS Yu, JC Yun, L Zanello, A Zanetti, I Zaw, F Zetti, X Zhang, J Zhou, S Zucchelli, CDF Collaboration
Dec 15, 2021
The production cross-sections of $J/\psi$ mesons in proton-proton collisions
at a centre-of-mass energy of $\sqrt{s}=5$ TeV are measured using a data sample
corresponding to an integrated luminosity of...
Alphonse R. Dochez, 1925
The Rockefeller University
Jan 01, 0001
Alphonse R. Dochez. Etiology of Scarlet Fever
Lecture delivered January 17th, 1925
Posted with permission
Published by: J.B. Lippincott Company
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