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Ståle Nygård, Ole Christian Lingjaerde, Carlos Caldas, Eivind Hovig, Anne-Lise Børresen-Dale, Åslaug Helland, Vilde D Haakensen
Jan 09, 2020
Gene expression profiling of tumours is an important source of information for cancer patient stratification. Detecting subtle alterations of gene expression remains a challenge, however. Here, we propose a novel tool for...
Interview with Anne Porcher Perrin and Daughter, Anne Perrin Flynn
Interview with Anne Porcher Perrin, member of the South Carolina Mothers Association and South Carolina Mother of the Year Selection Committee, and Anne Perrin Flynn, member of the South Carolina Mothers Association.
Published by: Winthrop University
PathTracer
Ståle Nygård, Ole Christian Lingjaerde, Carlos Caldas, Eivind Hovig, Anne-Lise Børresen-Dale, Åslaug Helland, Vilde D. Haakensen
Nov 09, 2020
Abstract: Gene expression profiling of tumours is an important source of information for cancer patient stratification. Detecting subtle alterations of gene expression remains a challenge, however. Here, we propose a novel tool...
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.
Inga H Rye, Anne Trinh, Anna B Saetersdal, Daniel Nebdal, Ole Christian Lingjaerde, Vanessa Almendro, Kornelia Polyak, Anne-Lise Børresen-Dale, Åslaug Helland, Florian Markowetz, Hege G Russnes
Mar 04, 2019
Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and...
PathTracer
Ståle Nygård, Ole Christian Lingjaerde, Carlos Caldas, Eivind Hovig, Anne-Lise Børresen-Dale, Åslaug Helland, Vilde D Haakensen
Dec 10, 2019
Gene expression profiling of tumours is an important source of information for cancer patient stratification. Detecting subtle alterations of gene expression remains a challenge, however. Here, we propose a novel tool for...
Interview with Anne Perrin Flynn
Anne Perrin Flynn
Jan 01, 0001
Interview with Anne Perrin Flynn, member of the South Carolina Mothers Association.
Published by: Winthrop University
Interview with Tempe Anne Oehler and guest
Tempe Anne Oehler
Jan 01, 0001
Interview with Tempe Anne Oehler, 1990 South Carolina Mother of the Year.
Published by: Winthrop University
Interview with Anne Duncan
Anne Duncan
Jan 01, 0001
In her January 7, 2014 interview with Cody Willis, Anne Duncan reminisces of her time at Winthrop from 1974-1978 as a Physical Education major. This interview was conducted for inclusion into the Louise Pettus Archives and...
Published by: Winthrop University
Subtype-specific micro-RNA expression signatures in breast cancer progression.
Vilde D Haakensen, Vegard Nygaard, Liliana Greger, Miriam R Aure, Bastian Fromm, Ida RK Bukholm, Torben Lüders, Suet-Feung Chin, Anna Git, Carlos Caldas, Vessela N Kristensen, Alvis Brazma, Anne-Lise Børresen-Dale, Eivind Hovig, Åslaug Helland
Aug 09, 2016
DCIS biomarker breast cancer invasion miRNA subtype Biomarkers Tumor Breast Neoplasms Carcinoma Ductal breast Carcinoma Intraductal Noninfiltrating Chromosome Mapping Cluster Analysis Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans MicroRNAs Multigene Family Neoplasm Invasiveness Reproducibility of Results Transcriptome
Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity.
Ruth Dannenfelser, Marianne Nome, Andliena Tahiri, Josie Ursini-Siegel, Hans Kristian Moen Vollan, Vilde D Haakensen, Åslaug Helland, Bjørn Naume, Carlos Caldas, Anne-Lise Børresen-Dale, Vessela N Kristensen, Olga G Troyanskaya
Nov 28, 2018
The tumor microenvironment is now widely recognized for its role in tumor progression, treatment response, and clinical outcome. The intratumoral immunological landscape, in particular, has been shown to exert both...
Published by: Oncotarget
Copynumber
Gro Nilsen, Knut Liestøl, Peter Van Loo, Hans Kristian Moen Vollan, Marianne B Eide, Oscar M Rueda, Suet-Feung Chin, Roslin Russell, Lars O Baumbusch, Carlos Caldas, Anne-Lise Børresen-Dale, Ole Christian Lingjaerde
Feb 26, 2013
Anne Bogart: Theatre Should Explore More and Explain Less
An interview with director Anne Bogart & synopsis of her address to the 2006 Southeastern Theatre Conference annual convention.
Anne Bogart Viewpoints Southeastern Theatre Conference Arts and Humanities Performance Studies Theatre and Performance Studies
Published by: Winthrop University
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.
Hans Kristian Moen Vollan, Oscar M Rueda, Suet-Feung Chin, Christina Curtis, Gulisa Turashvili, Sohrab Shah, Ole Christian Lingjaerde, Yinyin Yuan, Charlotte K Ng, Mark J Dunning, Ed Dicks, Elena Provenzano, Stephen Sammut, Steven McKinney, Ian O Ellis, Sarah Pinder, Arnie Purushotham, Leigh C Murphy, Vessela N Kristensen, METABRIC Group, James D Brenton, Paul DP Pharoah, Anne-Lise Børresen-Dale, Samuel Aparicio, Carlos Caldas
Nov 08, 2017
Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations...
DNA copy number motifs are strong and independent predictors of survival in breast cancer.
Arne V Pladsen, Gro Nilsen, Oscar M Rueda, Miriam R Aure, Ørnulf Borgan, Knut Liestøl, Valeria Vitelli, Arnoldo Frigessi, Anita Langerød, Anthony Mathelier, OSBREAC, Olav Engebråten, Vessela Kristensen, David C Wedge, Peter Van Loo, Carlos Caldas, Anne-Lise Børresen-Dale, Hege G Russnes, Ole Christian Lingjaerde
May 29, 2020
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome...
Lois Anne Dollard and Dorothy Brunson Jan. 7, 1947
Winthrop News Service
Jan 01, 0001
Lois Anne Dollard and Dorothy Brunson of Sumter were contributors to the winter edition of The Journal, Winthrop College's literary publication. Miss Dollard wrote a poem and an essay, and Miss Brunson published a sonnet.
Published by: Winthrop University
Estate Gift from Anne Moss Biggs to Fund Freshman Scholarships
Winthrop University
Jan 01, 0001
The initial gifts from the estate have created scholarship support for Winthrop students through the Anne Moss Biggs Endowed Scholarship, with first preference given to non-traditional students. Biggs, of Lumberton, N.C., who...
Published by: Winthrop University
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group, Anita Langerød, Andrew Green, Elena Provenzano, Gordon Wishart, Sarah Pinder, Peter Watson, Florian Markowetz, Leigh Murphy, Ian Ellis, Arnie Purushotham, Anne-Lise Børresen-Dale, James D Brenton, Simon Tavaré, Carlos Caldas, Samuel Aparicio
Feb 13, 2020
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene...
Breast Neoplasms DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genes Neoplasm Genome Human Genomics Humans Kaplan-Meier Estimate MAP Kinase Kinase 4 Polymorphism Single Nucleotide Prognosis Protein Phosphatase 2 Treatment Outcome
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.
Arie B Brinkman, Serena Nik-Zainal, Femke Simmer, F Germán Rodríguez-González, Marcel Smid, Ludmil B Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J van de Vijver, Anne-Lise Børresen-Dale, Andrea L Richardson, GIlles Thomas, Ivo G Gut, John WM Martens, John A Foekens, Michael R Stratton, Hendrik G Stunnenberg
May 03, 2019
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the...
Obituary
Anne Ferguson-Smith and Marisa Bartolomei look back at the life and science of Denise Barlow, a pioneer in genomic imprinting and epigenetics.
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Helen Davies, Dominik Glodzik, Sandro Morganella, Lucy R Yates, Johan Staaf, Xueqing Zou, Manasa Ramakrishna, Sancha Martin, Sandrine Boyault, Anieta M Sieuwerts, Peter T Simpson, Tari A King, Keiran Raine, Jorunn E Eyfjord, Gu Kong, Åke Borg, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, Anne-Lise Børresen-Dale, John WM Martens, Paul N Span, Sunil R Lakhani, Anne Vincent-Salomon, Christos Sotiriou, Andrew Tutt, Alastair M Thompson, Steven Van Laere, Andrea L Richardson, Alain Viari, Peter J Campbell, Michael R Stratton, Serena Nik-Zainal
Dec 07, 2020
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic...
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.
Miriam Ragle Aure, Valeria Vitelli, Sandra Jernström, Surendra Kumar, Marit Krohn, Eldri U Due, Tonje Husby Haukaas, Suvi-Katri Leivonen, Hans Kristian Moen Vollan, Torben Lüders, Einar Rødland, Charles J Vaske, Wei Zhao, Elen K Møller, Silje Nord, Guro F Giskeødegård, Tone Frost Bathen, Carlos Caldas, Trine Tramm, Jan Alsner, Jens Overgaard, Jürgen Geisler, Ida RK Bukholm, Bjørn Naume, Ellen Schlichting, Torill Sauer, Gordon B Mills, Rolf Kåresen, Gunhild M Mælandsmo, Ole Christian Lingjaerde, Arnoldo Frigessi, Vessela N Kristensen, Anne-Lise Børresen-Dale, Kristine K Sahlberg, OSBREAC
May 05, 2017
BACKGROUND: Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes....
Breast Cancer Consensus clustering integration Luminal A microRNA Biomarkers Tumor Breast Neoplasms Cluster Analysis DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Humans Metabolic Networks and Pathways Metabolomics MicroRNAs Norway Prognosis RNA Messenger
A deep hierarchy of predictions enables online meaning extraction in a computational model of human speech comprehension.
Understanding speech requires mapping fleeting and often ambiguous soundwaves to meaning. While humans are known to exploit their capacity to contextualize to facilitate this process, how internal knowledge is deployed online...
Published by: PLoS biology
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Marcel Smid, F Germán Rodríguez-González, Anieta M Sieuwerts, Roberto Salgado, Wendy JC Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B Brinkman, Marc J van de Vijver, Andrea L Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R Davies, Reno Debets, Marion E Meijer-Van Gelder, Carolien HM van Deurzen, Gaëtan MacGrogan, Gert GGM Van den Eynden, Colin Purdie, Alastair M Thompson, Carlos Caldas, Paul N Span, Peter T Simpson, Sunil R Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P Andrew Futreal, Stian Knappskog, Tari King, GIlles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G Stunnenberg, Mike Stratton, John A Foekens, John WM Martens
Sep 29, 2018
A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific...
Alumna's Scholarship Supports Women Pursuing Degrees in Math, Sciences
Winthrop University
Jan 01, 0001
Sadie Livingston Boyer '58 and her husband, Dale, have established the Sadie Livingston Boyer - Dale Boyer Endowed Scholarship Fund to encourage young women pursuing careers in math and science. Boyer, herself a former...
Published by: Winthrop University
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