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Results: 46
Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation.
Liliya Euro, Svetlana Konovalova, Jorge Asin-Cayuela, Már Tulinius, Helen Griffin, Rita Horvath, Robert W Taylor, Patrick F Chinnery, Ulrike Schara, David R Thorburn, Anu Suomalainen, Joseph Chihade, Henna Tyynismaa
Mar 07, 2019
The accuracy of mitochondrial protein synthesis is dependent on the coordinated action of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mtARSs) and the mitochondrial DNA-encoded tRNAs. The recent advances in...
Examining the Moderating Effect of Green Product Knowledge on Green Product Advertising and Green Product Purchase Intention
Green products are essential for future and present generations, as they are safe for the environment and once disposed will easily get recycled. The world has recognised this fact and there has been lot of research on this as...
Published by: IGI Global Scientific Publishing
Fostering Entrepreneurship Education by Improving Assessment Rubrics for Entrepreneurship Competence
This chapter describes a tool for assessing the development of learners' entrepreneurship competence and its construction process. Competence in entrepreneurship is promoted at all school levels, but there are very few tools for...
classroom management Education Learning Assessment and Measurement Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Segmenting Reviewers Based on Reviewer and Review Characteristics
Being experiential commodities, it becomes difficult to make any judgment about hotels or attractions before their utilization. This is where the reviews provided by guests/tourists play an influential role. Therefore, it...
Published by: IGI Global Scientific Publishing
Smart Contract-Based Secure Decentralized Smart Healthcare System
Social distancing has been imposed to prevent substantial transmission of the COVID-19 outbreak, which is presently a global public health issue. Medical healthcare providers rely on telemedicine to monitor their patients...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate
Tanja Hyvärinen, Anu Hyysalo, Fikret Emre Kapucu, Laura Aarnos, Andrey Vinogradov, Stephen J. Eglen, Laura Ylä-Outinen, Susanna Narkilahti
Nov 19, 2020
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate
Tanja Hyvärinen, Anu Hyysalo, Fikret Emre Kapucu, Laura Aarnos, Andrey Vinogradov, Stephen J Eglen, Laura Ylä-Outinen, Susanna Narkilahti
Nov 21, 2019
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Published by: IGI Global Scientific Publishing
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
The Genetic Origin of Daunians and the Pan-Mediterranean Southern Italian Iron Age Context.
Serena Aneli, Tina Saupe, Francesco Montinaro, Anu Solnik, Ludovica Molinaro, Cinzia Scaggion, Nicola Carrara, Alessandro Raveane, Toomas Kivisild, Mait Metspalu, Christiana L Scheib, Luca Pagani
Feb 17, 2022
The geographical location and shape of Apulia, a narrow land stretching out in the sea at the South of Italy, made this region a Mediterranean crossroads connecting Western Europe and the Balkans. Such movements culminated at...
Can a 'rewards-for-exercise app' increase physical activity, subjective well-being and sleep quality? An open-label single-arm trial among university staff with low to moderate physical activity levels.
Sakari Lemola, Anna Gkiouleka, Brieze Read, Anu Realo, Lukasz Walasek, Nicole KY Tang, Mark T Elliott
Apr 23, 2021
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate
Tanja Hyvärinen, Anu Hyysalo, Fikret Emre Kapucu, Laura Aarnos, Andrey Vinogradov, Stephen J Eglen, Laura Ylä-Outinen, Susanna Narkilahti
Jan 03, 2020
Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in vitro modeling of neurological diseases and for advancing drug development and neurotoxicological studies. However, generating...
Retrospective natural history of thymidine kinase 2 deficiency.
Caterina Garone, Robert W Taylor, Andrés Nascimento, Joanna Poulton, Carl Fratter, Cristina Domínguez-González, Julie C Evans, Mariana Loos, Pirjo Isohanni, Anu Suomalainen, Dipak Ram, M Imelda Hughes, Robert McFarland, Emanuele Barca, Carlos Lopez Gomez, Sandeep Jayawant, Neil D Thomas, Adnan Y Manzur, Karin Kleinsteuber, Miguel A Martin, Timothy Kerr, Grainne S Gorman, Ewen W Sommerville, Patrick F Chinnery, Monika Hofer, Christoph Karch, Jeffrey Ralph, Yolanda Cámara, Marcos Madruga-Garrido, Jana Domínguez-Carral, Carlos Ortez, Sonia Emperador, Julio Montoya, Anupam Chakrapani, Joshua F Kriger, Robert Schoenaker, Bruce Levin, John LP Thompson, Yuelin Long, Shamima Rahman, Maria Alice Donati, Salvatore DiMauro, Michio Hirano
Apr 17, 2019
BACKGROUND: Thymine kinase 2 (TK2) is a mitochondrial matrix protein encoded in nuclear DNA and phosphorylates the pyrimidine nucleosides: thymidine and deoxycytidine. Autosomal recessive TK2 mutations cause a spectrum of...
Clinical genetics metabolic disorders muscle disease Neuromuscular disease Adolescent Adult Age of Onset Aged Child Child Preschool Female Genes Recessive Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Infant Infant Newborn Male Middle Aged Mitochondrial Proteins Muscle Skeletal Muscular Diseases Mutation Phenotype Retrospective Studies Survival Analysis Thymidine Kinase Young Adult
An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.
Meriam Guellil, Marcel Keller, Jenna M Dittmar, Sarah A Inskip, Craig Cessford, Anu Solnik, Toomas Kivisild, Mait Metspalu, John E Robb, Christiana L Scheib
Mar 06, 2022
BACKGROUND: The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the...
Spontaneous pneumothorax can be associated with TGFBR2 mutation.
Joseph E Chambers, Lucy E Dalton, Deepak N Subramanian, Bibek Gooptu, Anu Balan, Soo-Mi Park, Simon Holden, Stefan J Marciniak
Aug 27, 2015
An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.
Meriam Guellil, Marcel Keller, Jenna M Dittmar, Sarah A Inskip, Craig Cessford, Anu Solnik, Toomas Kivisild, Mait Metspalu, John E Robb, Christiana L Scheib
Feb 03, 2022
BACKGROUND: The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the...
Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies.
Alexander Hendricks, Anu Amallraja, Tobias Meißner, Peter Forster, Philip Rosenstiel, Greta Burmeister, Clemens Schafmayer, Andre Franke, Sebastian Hinz, Michael Forster, Casey B Williams
Feb 09, 2020
Personalized treatment vs. standard of care is much debated, especially in clinical practice. Here we investigated whether overall survival differences in metastatic colorectal cancer patients are explained by tumor mutation...
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula.
Gyaneshwer Chaubey, Monika Karmin, Ene Metspalu, Mait Metspalu, Deepa Selvi-Rani, Vijay Kumar Singh, Jüri Parik, Anu Solnik, B Prathap Naidu, Ajay Kumar, Niharika Adarsh, Chandana Basu Mallick, Bhargav Trivedi, Swami Prakash, Ramesh Reddy, Parul Shukla, Sanjana Bhagat, Swati Verma, Samiksha Vasnik, Imran Khan, Anshu Barwa, Dipti Sahoo, Archana Sharma, Mamoon Rashid, Vishal Chandra, Alla G Reddy, Antonio Torroni, Robert A Foley, Kumarasamy Thangaraj, Lalji Singh, Toomas Kivisild, Richard Villems
Jun 14, 2011
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom C M Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
aging Prevention Alzheimer’s disease Dementia Risk Factors Public Health Risk profiling Brain Health Services
Published by: Alzheimer's research & therapy
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom CM Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn, European Task Force for Brain Health Services
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6
Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Giovanni B. Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J. Llewellyn, Marc Abramowicz, Daniele Altomare, Marcelo Berthier, Melanie Bieler, Andrea Brioschi, Emmanuel Carrera, Gael Chételat, Chantal Csajka, Jean-François Demonet, Alessandra Dodich, Bruno Dubois, Valentina Garibotto, Jean Georges, Samia Hurst, Miia Kivipelto, David J. Llewellyn, Laura McWhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, Peter M. Nilsson, Craig Ritchie, Alina Solomon, Wiesje van der Flier, Bruno Vellas, Leonie Visser
Nov 03, 2021
Abstract: We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals...
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6
Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Giovanni B. Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J. Llewellyn, Marc Abramowicz, Daniele Altomare, Marcelo Berthier, Melanie Bieler, Andrea Brioschi, Emmanuel Carrera, Gael Chételat, Chantal Csajka, Jean-François Demonet, Alessandra Dodich, Bruno Dubois, Valentina Garibotto, Jean Georges, Samia Hurst, Miia Kivipelto, David J. Llewellyn, Laura McWhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, Peter M. Nilsson, Craig Ritchie, Alina Solomon, Wiesje van der Flier, Bruno Vellas, Leonie Visser
Oct 13, 2021
Abstract: We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals...
The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East.
Lehti Saag, Margot Laneman, Liivi Varul, Martin Malve, Heiki Valk, Maria A Razzak, Ivan G Shirobokov, Valeri I Khartanovich, Elena R Mikhaylova, Alena Kushniarevich, Christiana Lyn Scheib, Anu Solnik, Tuuli Reisberg, Jüri Parik, Lauri Saag, Ene Metspalu, Siiri Rootsi, Francesco Montinaro, Maido Remm, Reedik Mägi, Eugenia D'Atanasio, Enrico Ryunosuke Crema, David Díez-Del-Molino, Mark G Thomas, Aivar Kriiska, Toomas Kivisild, Richard Villems, Valter Lang, Mait Metspalu, Kristiina Tambets
May 03, 2019
In this study, we compare the genetic ancestry of individuals from two as yet genetically unstudied cultural traditions in Estonia in the context of available modern and ancient datasets: 15 from the Late Bronze Age stone-cist...
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