Search
Results: 392
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gallipoli, Carsten Müller-Tidow, Cameron S Osborne, George S Vassiliou, Brian JP Huntly
Aug 12, 2021
Animals Base Sequence Chromatin Assembly and Disassembly DNA Neoplasm Disease Models Animal Enhancer Elements Genetic Gene Expression Regulation Leukemic Gene Regulatory Networks Genetic Loci Histones Humans Leukemia Myeloid Acute Mice Inbred C57BL Mutation Nuclear Proteins Nucleophosmin principal component analysis Protein Processing Post-Translational RNA Messenger Transcription Genetic fms-Like Tyrosine Kinase 3
Phylogeography of Lyme borreliosis-group spirochetes and methicillin-resistant <em>Staphylococcus aureus</em>
Multilocus sequence typing (MLST) and multilocus sequence analysis (MLSA) have revolutionized understanding the global epidemiology of many medically relevant bacteria utilizing a number, mostly seven, of housekeeping genes. A...
Young Citizens Participation
A growing body of literature from different disciplines addresses concepts and measurement of citizenship. The present article seeks to contribute to this field by examining the issue of youth citizenship from a comparative...
Non-axisymmetric complete flow conditioning gauzes
Abstract: This paper presents a novel methodology for the design of a gauze that produces distributions of stagnation pressure, swirl angle, pitch angle and turbulence intensity, tailored in both the radial and circumferential...
Young Citizens Participation
A growing body of literature from different disciplines addresses concepts and measurement of citizenship. The present article seeks to contribute to this field by examining the issue of youth citizenship from a comparative...
Non-axisymmetric complete flow conditioning gauzes
Abstract: This paper presents a novel methodology for the design of a gauze that produces distributions of stagnation pressure, swirl angle, pitch angle and turbulence intensity, tailored in both the radial and circumferential...
Protein amino acid composition
Large brains relative to body size represent an evolutionarily costly adaptation as they are metabolically expensive and demand substantial amounts of time to reach structural and functional maturity thereby exacerbating...
Phylogeography of Lyme borreliosis-group spirochetes and methicillin-resistant <em>Staphylococcus aureus</em>
Multilocus sequence typing (MLST) and multilocus sequence analysis (MLSA) have revolutionized understanding the global epidemiology of many medically relevant bacteria utilizing a number, mostly seven, of housekeeping genes. A...
Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers.
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and...
Protein amino acid composition
Large brains relative to body size represent an evolutionarily costly adaptation as they are metabolically expensive and demand substantial amounts of time to reach structural and functional maturity thereby exacerbating...
Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and...
Materials Formed by Combining Inorganic Glasses and Metal-Organic Frameworks.
Ashleigh M Chester, Celia Castillo-Blas, Lothar Wondraczek, David A Keen, Thomas D Bennett
May 25, 2022
Here, we propose the combination of glassy or crystalline metal-organic frameworks (MOFs) with inorganic glasses to create novel hybrid composites and blends.The motivation behind this new composite approach is to improve the...
Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions
Genomic determinants underlying increased encephalization across mammalian lineages are unknown. Whole genome comparisons have revealed large and frequent changes in the size of gene families, and it has been proposed that these...
Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions
Genomic determinants underlying increased encephalization across mammalian lineages are unknown. Whole genome comparisons have revealed large and frequent changes in the size of gene families, and it has been proposed that these...
Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development
Background
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
Psychological treatments for the management of pain following musculoskeletal injury
Rachel Aaron, Fenan Rassu, Stephen Wegener, Amy L. Holley, Renan Castillo, Greg Osgood, Emma Fisher
Dec 31, 2023
Musculoskeletal injury is a leading cause of pain and disability worldwide; 35-75% of people experience persistent pain for months and years after injury. Psychological treatments can reduce pain, functional impairment and...
Psychological treatments for the management of pain following musculoskeletal injury
Rachel Aaron, Fenan Rassu, Stephen Wegener, Amy L. Holley, Renan Castillo, Greg Osgood, Emma Fisher
Dec 31, 2023
Musculoskeletal injury is a leading cause of pain and disability worldwide; 35-75% of people experience persistent pain for months and years after injury. Psychological treatments can reduce pain, functional impairment and...
Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer’s disease
Wencheng Yin, Navei Cerda Hernandez, Atahualpa Castillo Morales, Mayra Ruiz Tejada Segura, Jimena Monzón Sandoval, Perla Moreno Castillo, Rodrigo Perez Ortega, Federico Bermudez Rattoni, Araxi Urrutia, Humberto Gutierrez
Dec 15, 2020
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and...
Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer’s disease
Wencheng Yin, Navei Cerda Hernandez, Atahualpa Castillo Morales, Mayra Ruiz Tejada Segura, Jimena Monzón Sandoval, Perla Moreno Castillo, Rodrigo Perez Ortega, Federico Bermudez Rattoni, Araxi Urrutia, Humberto Gutierrez
Dec 15, 2020
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and...
Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development
Background
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis.
Juan Castillo-Fernandez, Erika Herrera-Puerta, Hannah Demond, Stephen J Clark, Courtney W Hanna, Myriam Hemberger, Gavin Kelsey
Jan 11, 2021
Advancing maternal age causes a progressive reduction in fertility. The decline in developmental competence of the oocyte with age is likely to be a consequence of multiple contributory factors. Loss of epigenetic quality of the...
Body Composition changes after Testosterone Replacement Therapy following Spinal Cord Injury and Aging
Tom Nightingale, Pam Moore, Joshua Harman, Refka Khalil, Ranjodh Gill, Teodoro Castillo, Robert Adler, Ashraf Gorgey
Jan 01, 0001
CONTEXT: Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood...
|
|< |
< |
1 |