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Results: 29
Regulation of Surface Proteins Assembly on the Wall of Gram-Positive Bacteria
Assaf Raz
Jan 01, 0001
Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many Gram-positive bacteria. Attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase...
streptococcal disease Gram-Positive Bacteria surface proteins sortase localization protein anchoring sub-surface antigens LPXTGase Life Sciences
Published by: Rockefeller University
Entrepreneurial Work-Integrated Learning
After decades of decreasing long-term job security and ongoing global economic crises, attention on and interest in entrepreneurship have significantly increased among Gen Y and Gen Z students in higher education institutions...
Published by: IGI Global Scientific Publishing
On the "Matsubara heating" of overtone intensities and Fermi splittings.
Classical molecular dynamics (MD) and imaginary-time path-integral dynamics methods underestimate the infrared absorption intensities of overtone and combination bands by typically an order of magnitude. Plé et al. [J. Chem....
Which quantum statistics-classical dynamics method is best for water?
There are a variety of methods for including nuclear quantum effects in dynamics simulations by combining quantum Boltzmann statistics with classical dynamics. Among them are thermostatted ring-polymer molecular dynamics...
Mechanical Regulation of Neurite Polarization and Growth
The densely packed microtubule (MT) array found in neuronal cell projections (neurites) serves two fundamental functions simultaneously: it provides a mechanically stable track for molecular motor-based transport and produces...
Imaging techniques in ALS.
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration of both upper and lower motor neuron located in the spinal cord and brainstem. Diagnosis of ALS is predominantly...
A multizone cerebellar chip for bioinspired adaptive robot control and sensorimotor processing
Emma D Wilson, Tareq Assaf, Jonathan M Rossiter, Paul Dean, John Porrill, Sean R Anderson, Martin J Pearson
Jan 31, 2021
The cerebellum is a neural structure essential for learning, which is connected via multiple zones to many different regions of the brain, and is thought to improve human performance in a large range of sensory, motor and...
Balanced gene dosage control rather than parental origin underpins genomic imprinting.
Ariella Weinberg-Shukron, Raz Ben-Yair, Nozomi Takahashi, Marko Dunjić, Alon Shtrikman, Carol A Edwards, Anne C Ferguson-Smith, Yonatan Stelzer
Sep 02, 2022
Mammalian parental imprinting represents an exquisite form of epigenetic control regulating the parent-specific monoallelic expression of genes in clusters. While imprinting perturbations are widely associated with developmental...
Preferential binding of unsaturated hydrocarbons in aryl-bisimidazolium·cucurbit[8]uril complexes furbishes evidence for small-molecule π-π interactions.
Whilst cucurbit[n]urils (CBn) have been utilized in gas encapsulation, only the smaller CBn (n = 5 and 6) have utility given their small cavity size. In this work, we demonstrate that the large cavity of CB8 can be tailored for...
Published by: Chemical science
A multizone cerebellar chip for bioinspired adaptive robot control and sensorimotor processing
Emma D Wilson, Tareq Assaf, Jonathan M Rossiter, Paul Dean, John Porrill, Sean R Anderson, Martin J Pearson
Jan 31, 2021
The cerebellum is a neural structure essential for learning, which is connected via multiple zones to many different regions of the brain, and is thought to improve human performance in a large range of sensory, motor and...
Guidelines for morpholino use in zebrafish.
Didier YR Stainier, Erez Raz, Nathan D Lawson, Stephen C Ekker, Rebecca D Burdine, Judith S Eisen, Philip W Ingham, Stefan Schulte-Merker, Deborah Yelon, Brant M Weinstein, Mary C Mullins, Stephen W Wilson, Lalita Ramakrishnan, Sharon L Amacher, Stephan CF Neuhauss, Anming Meng, Naoki Mochizuki, Pertti Panula, Cecilia B Moens
Oct 07, 2019
Host-Guest Chemistry Meets Electrocatalysis
Andreas Wagner, Khoa H Ly, Nina Heidary, István Szabó, Tamás Földes, Khaleel I Assaf, Steven J Barrow, Kamil Sokołowski, Mohamed Al-Hada, Nikolay Kornienko, Moritz F Kuehnel, Edina Rosta, Ingo Zebger, Werner M Nau, Oren A Scherman, Erwin Reisner
Feb 14, 2020
The rational control of forming and stabilizing reaction intermediates to guide specific reaction pathways remains to be a major challenge in electrocatalysis. In this work, we report a surface active-site engineering approach...
Published by: ACS catalysis
Host-Guest Chemistry Meets Electrocatalysis
Biotic interactions as drivers of algal origin and evolution
Juliet Brodie, Steven G Ball, François-Yves Bouget, Cheong Xin Chan, Olivier De Clerck, J Mark Cock, Claire Gachon, Arthur R Grossman, Thomas Mock, John A Raven, Mahasweta Saha, Alison G Smith, Assaf Vardi, Hwan Su Yoon, Debashish Bhattacharya
Nov 24, 2017
Biotic interactions underlie life's diversity and are the lynchpin to understanding its complexity and resilience within an ecological niche. Algal biologists have embraced this paradigm, and studies building on the explosive...
Skorupskian Allyship: Human Rights Reconstructed Through Efficacious Enforcement and Social Relativism
Chase Opperman
Jan 01, 0001
This project aims to take the subject of Human Rights and attempt to wrestle with its clarity. The concept has been, since its more modern manifestation, as represented by the United Nations' Uniform Declaration of Human Rights...
Human Rights John Skorupski Joseph Raz international law social relativism globalization Arts and Humanities Ethics and Political Philosophy Human Rights Law Philosophy
Published by: Ursinus College
Benchmarked approaches for reconstruction of in vitro cell lineages and in silico models of C. elegans and M. musculus developmental trees.
Wuming Gong, Alejandro A Granados, Jingyuan Hu, Matthew G Jones, Ofir Raz, Irepan Salvador-Martínez, Hanrui Zhang, Ke-Huan K Chow, Il-Youp Kwak, Renata Retkute, Alidivinas Prusokas, Augustinas Prusokas, Alex Khodaverdian, Richard Zhang, Suhas Rao, Robert Wang, Phil Rennert, Vangala G Saipradeep, Naveen Sivadasan, Aditya Rao, Thomas Joseph, Rajgopal Srinivasan, Jiajie Peng, Lu Han, Xuequn Shang, Daniel J Garry, Thomas Yu, Verena Chung, Michael Mason, Zhandong Liu, Yuanfang Guan, Nir Yosef, Jay Shendure, Maximilian J Telford, Ehud Shapiro, Michael B Elowitz, Pablo Meyer
Jun 25, 2021
The recent advent of CRISPR and other molecular tools enabled the reconstruction of cell lineages based on induced DNA mutations and promises to solve the ones of more complex organisms. To date, no lineage reconstruction...
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Glenn R Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, Sébastien Brier, George M Bou-Assaf, John R Engen, S Walter Englander, Johan Faber, Rachel Garlish, Patrick R Griffin, Michael L Gross, Miklos Guttman, Yoshitomo Hamuro, Albert JR Heck, Damian Houde, Roxana E Iacob, Thomas JD Jørgensen, Igor A Kaltashov, Judith P Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S Strutzenberg, Eric S Underbakke, Cornelia Wagner, Thomas E Wales, Benjamin T Walters, David D Weis, Derek J Wilson, Patrick L Wintrode, Zhongqi Zhang, Jie Zheng, David C Schriemer, Kasper D Rand
Jun 26, 2020
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Jul 29, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Animals Basic-Leucine Zipper Transcription Factors Cell Line Tumor Cell Proliferation Cell Survival Gene Expression Regulation Neoplastic Humans Immunoconjugates Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Ki-1 Antigen Lymphoma Large-Cell Anaplastic Mice Receptors Interleukin-2 Regulatory Sequences Nucleic Acid Repressor Proteins Signal Transduction Xenograft Model Antitumor Assays
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Oct 24, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Published by: Nature Communications
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