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Germ cell specification and pluripotency in mammals
Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving rise to the next generation in mammals and many other multicellular organisms. How germ cells acquire this ability has been of...
On the origin of the human germline.
In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study...
Amnion Epiblast Epigenetic resetting Gastrulation human development primordial germ cells Signalling Transcription Factors Animals Cell Differentiation Embryo Mammalian Embryonic Development Embryonic Stem Cells Epigenesis Genetic Gene Regulatory Networks Germ Cells Germ Layers Human Embryonic Stem Cells Humans Mice Pluripotent Stem Cells
The unfolding body plan of primate embryos in culture.
Improved culture of non-human primate embryos reveals the establishment of the crucial framework for subsequent development of bodily tissues and the germline in fetuses, bringing us closer to comprehending the elusive...
Recombination and Excision: DNA Repair Proteins in Prokaryotic Host-Virus Conflicts
Amer Azim Hossain
Jan 01, 0001
Bacteriophages, or simply phages, are viruses that infect bacteria. They are the most abundant biological entity on our planet and outnumber bacteria 10:1 in the ocean. In response to this threat, bacteria have evolved a diverse...
Published by: Rockefeller University
In retrospect
M Azim Surani
Nov 27, 2019
Pluripotent cells have the potential to differentiate into any cell type in the body. Their isolation and propagation from mouse embryos was pivotal for advances in understanding human development and disease.
Conserved features of non-primate bilaminar disc embryos and the germline.
Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos...
Privacy-Preserving Gaze Data Streaming in Immersive Interactive Virtual Reality
Ethan Wilson, Azim Ibragimov, Michael Proulx, Sai Deep Tetali, Kevin Butler, Eakta Jain
May 31, 2024
Eye tracking is routinely being incorporated into virtual reality (VR) systems. Prior research has shown that eye tracking data, if exposed, can be used for re-identification attacks [14]. The state of our knowledge about...
Specification and epigenetic programming of the human germ line.
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent...
Developmental Competence for Primordial Germ Cell Fate.
During mammalian embryonic development, the trophectoderm and primitive endoderm give rise to extraembryonic tissues, while the epiblast differentiates into all somatic lineages and the germline. Remarkably, only a few classes...
Possible Impacts of Climate Changes on Freshwater in Coastal Aquifers
Groundwater resources in coastal aquifers constitute a main source of freshwater in many regions around the globe. This is typically true in arid and semi-arid regions where rainfall is scarce and infrequent and the surface...
Testing the role of SOX15 in human primordial germ cell fate.
Background: Potentially novel regulators of early human germline development have been identified recently, including SOX15 and SOX17, both of which show specific expression in human primordial germ cells. SOX17 is now known to...
Possible Impacts of Climate Changes on Freshwater in Coastal Aquifers
Groundwater resources in coastal aquifers constitute a main source of freshwater in many regions around the globe. This is typically true in arid and semi-arid regions where rainfall is scarce and infrequent and the surface...
Privacy-Preserving Gaze Data Streaming in Immersive Interactive Virtual Reality
Ethan Wilson, Azim Ibragimov, Michael Proulx, Sai Deep Tetali, Kevin Butler, Eakta Jain
May 31, 2024
Eye tracking is routinely being incorporated into virtual reality (VR) systems. Prior research has shown that eye tracking data, if exposed, can be used for re-identification attacks [14]. The state of our knowledge about...
Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.
Jan J Zylicz, Sabine Dietmann, Ufuk Günesdogan, Jamie A Hackett, Delphine Cougot, Caroline Lee, M Azim Surani
Nov 24, 2015
Chromosomes developmental biology Epiblast epigenetics Genes histone MOUSE post-implantation primed pluripotency Stem Cells Animals Chromatin Embryonic Development Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation Developmental Histone-Lysine N-Methyltransferase Histones Methylation Mice Polycomb Repressive Complex 2 Protein Processing Post-Translational
Blastocyst complementation using Prdm14 -deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats
Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Fumika Yoshida, Reiko Terada, Naoko Niizeki, Naoyo Kajitani, Kanako Kazuki, Yasuhiro Kazuki, Shinichi Hochi, Hiromitsu Nakauchi, M. Azim Surani, Masumi Hirabayashi
Feb 26, 2021
Abstract: Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies....
PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.
Shinseog Kim, Ufuk Günesdogan, Jan J Zylicz, Jamie A Hackett, Delphine Cougot, Siqin Bao, Caroline Lee, Sabine Dietmann, George E Allen, Roopsha Sengupta, M Azim Surani
Apr 14, 2015
Animals Apoptosis Blastocyst Cells Cultured DNA Damage DNA Methylation DNA Transposable Elements Embryonic Development Embryonic Stem Cells Female Genomic Instability Histones Male Mice Transgenic Ovum Protein Methyltransferases Protein Processing Post-Translational Protein-Arginine N-Methyltransferases Spermatozoa
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Anastasiya Sybirna, Walfred W C Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H Gruhn, Ran Brosh, M Azim Surani
Apr 11, 2020
PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a...
Published by: Nature Communications
DNMTs Play an Important Role in Maintaining the Pluripotency of Leukemia Inhibitory Factor-Dependent Embryonic Stem Cells.
Baojiang Wu, Yunxia Li, Bojiang Li, Baojing Zhang, Yanqiu Wang, Lin Li, Junpeng Gao, Yuting Fu, Shudong Li, Chen Chen, M Azim Surani, Fuchou Tang, Xihe Li, Siqin Bao
Apr 16, 2021
Naive pluripotency can be maintained in medium with two inhibitors plus leukemia inhibitory factor (2i/LIF) supplementation, which primarily affects canonical WNT, FGF/ERK, and JAK/STAT3 signaling. However, whether one of these...
DNA Methylation DNMTs DIFFERENTIATION Embryonic Stem Cells epigenetic Genomic Imprinting Leukemia Inhibitory Factor MOUSE Pluripotency self-renew Animals Cell Culture Techniques Cell Differentiation Cell Self Renewal Cells Cultured Culture Media DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Gene Expression Regulation Developmental Gene Knockout Techniques Genomic Imprinting Germ Layers Janus Kinases Leukemia Inhibitory Factor Mice Mice Inbred C57BL Mice Transgenic Mouse embryonic stem cells STAT3 Transcription Factor Signal Transduction Transcriptome
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