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Results: 437
TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response.
Raquel Espín-Palazón, Alicia Martínez-López, Francisco J Roca, Azucena López-Muñoz, Sylwia D Tyrkalska, Sergio Candel, Diana García-Moreno, Alberto Falco, José Meseguer, Amparo Estepa, Victoriano Mulero
May 13, 2019
TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize the host produced TNFα to their benefit....
Cellular senescence in cancer
Hui‐Ling Ou, Reuben Hoffmann, Cristina González‐López, Gary J. Doherty, James E. Korkola, Daniel Muñoz‐Espín
Oct 01, 2021
Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in response to stress. This response also involves other distinct morphological and intracellular changes including alterations in gene...
Published by: Molecular Oncology
Cellular senescence in cancer
Hui-Ling Ou, Reuben Hoffmann, Cristina González-López, Gary J Doherty, James E Korkola, Daniel Muñoz-Espín
Jan 18, 2021
Senescence refers to a cellular state featuring a stable cell-cycle arrest triggered in response to stress. This response also involves other distinct morphological and intracellular changes including alterations in gene...
Spanish Professor Selected as Thompson Scholar
Winthrop University
Jan 01, 0001
Spanish professor Pedro Muñoz has been chosen as the new Thompson Scholar. Muñoz, a native of Spain, will spend a year researching service learning courses for at-risk Hispanic students.
Published by: Winthrop University
Tail-regression estimator for heavy-tailed distributions of known tail indices and its application to continuum quantum Monte Carlo data.
Standard statistical analysis is unable to provide reliable confidence intervals on expectation values of probability distributions that do not satisfy the conditions of the central limit theorem. We present a regression-based...
Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in <em>Drosophila</em>
Initial genetic studies in Drosophila suggested that several members of the Rho subfamily (RhoA, Rac1 and Cdc42) are involved in planar cell polarity (PCP) establishment. However, analyses of Rac1, Rac2 and Mtl loss-of-function...
Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in <em>Drosophila</em>
Initial genetic studies in Drosophila suggested that several members of the Rho subfamily (RhoA, Rac1 and Cdc42) are involved in planar cell polarity (PCP) establishment. However, analyses of Rac1, Rac2 and Mtl loss-of-function...
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Brain responses to different types of salience in antipsychotic naïve first episode psychosis
Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murray
Oct 03, 2018
Abnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms has...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Estela González-Gualda, Marta Pàez-Ribes, Beatriz Lozano-Torres, David Macias, Joseph R Wilson, Cristina González-López, Hui-Ling Ou, Sofía Mirón-Barroso, Zhenguang Zhang, Araceli Lérida-Viso, Juan F Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P Martins, Manuel Serrano, Gary J Doherty, Ramón Martínez-Máñez, Daniel Muñoz-Espín
Mar 24, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease...
Navitoclax (ABT-263) Cellular Senescence chemotherapy-induced senescence Lung cancer prodrug senolytics Thrombocytopenia Aniline Compounds Animals Antineoplastic Agents Apoptosis Blood Platelets Cell Survival Cellular Senescence Drug Screening Assays Antitumor Female Galactose Humans Mice Mice Inbred C57BL Mice SCID Molecular Structure Neoplasms Experimental prodrugs Sulfonamides Tumor Cells Cultured
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy.
Dorian Forte, María García-Fernández, Abel Sánchez-Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana SH Costa, Laura Tronci, Efterpi Nikitopoulou, Michael Barber, Paolo Gallipoli, Ludovica Marando, Carlos López Fernández de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michele Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza, Brian J Huntly, Juerg Schwaller, Simón Méndez-Ferrer
Sep 03, 2020
OXPHOS TCA cycle acute myeloid leukemia antioxidant bone marrow mesenchymal stem cells Chemotherapy Glutathione hematopoietic stem cell niche metabolic adaptation microenvironment Animals Antineoplastic Agents antioxidants Bone Marrow Cells Cultured Energy Metabolism Female Humans Leukemia Myeloid Acute Male Mesenchymal Stem Cells Mice Mice Inbred C57BL Middle Aged
Expectation of reward differentially modulates executive inhibition.
Paula M Herrera, Alberto Vélez Van Meerbeke, Mario Speranza, Claudia López Cabra, Mauricio Bonilla, Michaël Canu, Tristan A Bekinschtein
Mar 16, 2020
BACKGROUND: Inhibitory control, a key modulatory component of cognition guiding strategy and behaviour, can be affected by diverse contingencies. We explore here the effect of expectation of reward over behavioural adjustment in...
Facing the future through entrepreneurship theory
In this paper, we address a thorny challenge: how can entrepreneurship scholarship enhance its impact without compromising the pursuit of conceptual rigor and theoretical novelty? We propose a prospective inquiry framework for...
Buying Through Social Platforms
Social platforms are currently encountering a set of burning issues: low ad conversion rates, cross-channel free-riding phenomena, lack of monetary incentives to retain premium content creators, etc. Direct purchase behaviors...
Published by: IGI Global Scientific Publishing
Facing the future through entrepreneurship theory
In this paper, we address a thorny challenge: how can entrepreneurship scholarship enhance its impact without compromising the pursuit of conceptual rigor and theoretical novelty? We propose a prospective inquiry framework for...
Influence of cutting environments on surface integrity and power consumption of austenitic stainless steel
Surface roughness is a result of the cutting parameters such as: cutting speed, feed per tooth and the axial depth of cut, also the tool's geometry, tool's wear vibrations, etc. Moreover, the surface finish influences...
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