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Delving Into the IT Governance-Management Communication Interface
This work is devoted to addressing the IT governance - management communication aspects, considering that their responsibilities are different, but complementary, in developing an IT governance framework. Our research question...
Published by: IGI Global Scientific Publishing
Early and Long-Term HIV-1 Immunogenicity Induced in Macaques by the Combined Administration of DNA, NYVAC and Env Protein-Based Vaccine Candidates
Beatriz Perdiguero, Benedikt Asbach, Carmen E Gómez, Josef Köstler, Susan W Barnett, Marguerite Koutsoukos, Deborah E Weiss, Anthony D Cristillo, Kathryn E Foulds, Mario Roederer, David C Montefiori, Nicole L Yates, Guido Ferrari, Xiaoying Shen, Sheetal Sawant, Georgia D Tomaras, Alicia Sato, William J Fulp, Raphael Gottardo, Song Ding, Jonathan L Heeney, Giuseppe Pantaleo, Mariano Esteban, Ralf Wagner
Aug 05, 2022
To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific...
Efficiency and accuracy of visual search develop at different rates from early childhood through early adulthood
Abstract: Most studies of visual search across the life span have focused on classic feature and conjunction searches in which observers search for a fixed, simple shape target among relatively homogeneous distractors over a...
Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.
Juan García-Arriaza, Beatriz Perdiguero, Jonathan Heeney, Michael Seaman, David C Montefiori, Celia Labranche, Nicole L Yates, Xiaoying Shen, Georgia D Tomaras, Guido Ferrari, Kathryn E Foulds, Adrian McDermott, Shing-Fen Kao, Mario Roederer, Natalie Hawkins, Steve Self, Jiansheng Yao, Patrick Farrell, Sanjay Phogat, Jim Tartaglia, Susan W Barnett, Brian Burke, Anthony Cristillo, Deborah Weiss, Carter Lee, Karen Kibler, Bert Jacobs, Benedikt Asbach, Ralf Wagner, Song Ding, Giuseppe Pantaleo, Mariano Esteban
Jun 19, 2015
Population biology and phenology of the colour polymorphic damselfly
<i>Ischnura elegans</i>
at its southern range limit in Cyprus
1. Geographically widespread species provide excellent opportunities to investigate how phenotypes change across large‐scale environmental gradients. Temperature is a fundamental environmental variable and an important...
Mending the Divide
Beatriz Santos Barreto
Apr 13, 2023
Latin American has made remarkable progress in the last twenty years regarding LGBTQ+ rights. More recently, LGBTQ‐related issues have had major impacts on national and regional politics. However, most of the literature about...
Propelling Children’s Empathy and Friendship
Schools play a crucial role in creating supportive and safe environments, and positive feelings are key in fostering such environments. Schools as Learning Communities, based on the dialogic participation of the whole...
Susana León-Jiménez, Beatriz Villarejo-Carballido, Garazi López de Aguileta, Lídia Puigvert
Sep 06, 2020
Statistical critical reactive maintenance characterisation for digital twin implementation in universities
Purpose: Facilities management (FM) plays a key role in the performance of businesses to ensure the comfort of users and the sustainable use of natural resources over operation and maintenance. Nevertheless, reactive...
Impact of Interactive Learning Environments on Learning and Cognitive Development of Children With Special Educational Needs
Children with special educational needs (SEN) achieve lower educational levels than their peers without special needs, leading to a higher risk of social exclusion in the future. Inclusive education aims to promote learning and...
Efficiency and accuracy of visual search develop at different rates from early childhood through early adulthood.
L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation.
Beatriz Castejón-Vega, Alejandro Rubio, Antonio J Pérez-Pulido, José L Quiles, Jon D Lane, Beatriz Fernández-Domínguez, María Begoña Cachón-González, Carmen Martín-Ruiz, Alberto Sanz, Timothy M Cox, Elísabet Alcocer-Gómez, Mario D Cordero
Jan 07, 2022
AIMS: Tay-Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that cause progressive neurodegeneration in infants and young children. Impaired hydrolysis catalysed by...
GM2 gangliosidosis L-arginine Autophagy mTOR Arginine Autophagosomes Autophagy Cathepsins FIBROBLASTS Gangliosidoses GM2 Hexosaminidase A Hexosaminidase B Humans Lysosomes Mutation Permeability Proto-Oncogene Proteins c-akt Sandhoff Disease Signal Transduction TOR Serine-Threonine Kinases Tay-Sachs Disease Transcriptome
Statistical critical reactive maintenance characterisation for digital twin implementation in universities
Purpose: Facilities management (FM) plays a key role in the performance of businesses to ensure the comfort of users and the sustainable use of natural resources over operation and maintenance. Nevertheless, reactive...
Efficiency and accuracy of visual search develop at different rates from early childhood through early adulthood
Abstract: Most studies of visual search across the life span have focused on classic feature and conjunction searches in which observers search for a fixed, simple shape target among relatively homogeneous distractors over a...
The effect of a change in co-payment on prescription drug demand in a National Health System
Cristina Hernández-Izquierdo, Beatriz González López-Valcárcel, Stephen Morris, Mariya Melnychuk, Ignacio Abásolo Alessón
Feb 24, 2020
OBJECTIVES: To test the heterogeneity of the effect of a change in pharmaceutical cost-sharing by therapeutic groups in a Spanish region. METHODS: Data: random sample (provided by the Canary Islands Health Service) of 40,471...
Modelling and Coordination of Building design
Marcio Presente de Souza, Beatriz Campos Fialho, Rita Cristina Ferreira, Marcio Minto Fabricio, Ricardo Codinhoto
Jan 31, 2023
The implementation of Building Information Modelling (BIM) in the Architecture, Engineering, Construction and Operations (AECO) industry requires multidisciplinary teams equipped with new technical and managerial skills....
L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation
Beatriz Castejón-Vega, Alejandro Rubio, Antonio J. Pérez-Pulido, José L. Quiles, Jon D. Lane, Beatriz Fernández-Domínguez, María Begoña Cachón-González, Carmen Martín-Ruiz, Alberto Sanz, Timothy M. Cox, Elísabet Alcocer-Gómez, Mario D. Cordero
Nov 22, 2021
Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that cause progressive neurodegeneration in infants and young children. Impaired hydrolysis catalysed by...
Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens.
Benedikt Asbach, Alexander Kliche, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L Jacobs, David C Montefiori, Celia C LaBranche, Nicole L Yates, Georgia D Tomaras, Guido Ferrari, Kathryn E Foulds, Mario Roederer, Gary Landucci, Donald N Forthal, Michael S Seaman, Natalie Hawkins, Steven G Self, Alicia Sato, Raphael Gottardo, Sanjay Phogat, James Tartaglia, Susan W Barnett, Brian Burke, Anthony D Cristillo, Deborah E Weiss, Jesse Francis, Lindsey Galmin, Song Ding, Jonathan L Heeney, Giuseppe Pantaleo, Ralf Wagner
Apr 21, 2016
Pharmaceutical Manufacturing and Health Information Technology
Pharmaceutical companies are seen as slow in adopting principles of operation excellence and advanced technologies. This article aims to explore the reasons why an industry, recognized as profitable and intensive in capital and...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Resolving Recent Plant Radiations
Mario Fernández-Mazuecos, Greg Mellers, Beatriz Vigalondo, Llorenç Sáez, Pablo Vargas, Beverley J Glover
Mar 29, 2018
Disentangling species boundaries and phylogenetic relationships within recent evolutionary radiations is a challenge due to the poor morphological differentiation and low genetic divergence between species, frequently...
Modelling and Coordination of Building design
Marcio Presente de Souza, Beatriz Campos Fialho, Rita Cristina Ferreira, Marcio Minto Fabricio, Ricardo Codinhoto
Jan 31, 2023
The implementation of Building Information Modelling (BIM) in the Architecture, Engineering, Construction and Operations (AECO) industry requires multidisciplinary teams equipped with new technical and managerial skills....
Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds
Victoria Oakes, Johana Torralba, Edurne Rujas, José L Nieva, Carmen Domene, Beatriz Apellaniz
Jun 01, 2018
The 10E8 antibody achieves near-pan neutralization of HIV-1 by targeting the remarkably conserved gp41 membrane-proximal external region (MPER) and the connected transmembrane domain (TMD) of the HIV-1 envelope glycoprotein...
AIDS Vaccines Amino Acid Sequence Antibodies Neutralizing/immunology Antigen-Antibody Reactions Antigens Surface/chemistry Epitopes/immunology HIV Antibodies/immunology HIV Envelope Protein gp41/chemistry HIV-1/immunology Humans Liposomes Models Molecular Molecular Dynamics Simulation Peptide Fragments/immunology Protein Conformation Protein Domains /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.
Muscle differentiation requires the assembly of high-order structures called myofibrils, composed of sarcomeres. Even though the molecular organization of sarcomeres is well known, the mechanisms underlying myofibrillogenesis...
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Juan José Pérez-Moreno, Carmen Santa-Cruz Mateos, María Dolores Martín-Bermudo, Beatriz Estrada
Feb 20, 2022
Muscle development is a multistep process that involves cell specification, myoblast fusion, myotube migration, and attachment to the tendons. In spite of great efforts trying to understand the basis of these events, little is...
2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy.
Ilaria Muller, Carla Moran, Beatriz Lecumberri, Brigitte Decallonne, Neil Robertson, Joanne Jones, Colin M Dayan
May 03, 2019
Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated with alemtuzumab, a pan-lymphocyte depleting drug with...
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