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Results: 298
Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.
Sunwoo Lee, Eguzkine Ochoa, Katy Barwick, Laura Cif, Fay Rodger, France Docquier, Belén Pérez-Dueñas, Graeme Clark, Ezequiel Martin, Siddharth Banka, Manju A Kurian, Eamonn Maher
May 09, 2022
Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.
Sunwoo Lee, Eguzkine Ochoa, Katy Barwick, Laura Cif, Fay Rodger, France Docquier, Belén Pérez-Dueñas, Graeme Clark, Ezequiel Martin, Siddharth Banka, Manju A Kurian, Eamonn R Maher
May 17, 2022
Kabuki syndrome chromatin disorders early-onset dystonia histone lysine methyltransferases (KMTs) Methylation neurodevelopmental disorder Abnormalities Multiple DNA Methylation DNA-Binding Proteins Face Hematologic Diseases Histone-Lysine N-Methyltransferase Humans Mutation Neoplasm Proteins Phenotype Vestibular Diseases
Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.
Ana Rivera-Barahona, Esmeralda Alonso-Barroso, Belén Pérez, Michael P Murphy, Eva Richard, Lourdes R Desviat
Jun 18, 2018
Oxidative stress contributes to the pathogenesis of propionic acidemia (PA), a life threatening disease caused by the deficiency of propionyl CoA-carboxylase, in the catabolic pathway of branched-chain amino acids, odd-number...
Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm
David Sánchez-Infantes, Meritxell Nus, Miquel Navas-Madroñal, Joan Fité, Belén Pérez, Antonio J. Barros-Membrilla, Begoña Soto, José Martínez-González, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, María Galán
Apr 15, 2021
Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good...
Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm.
David Sánchez-Infantes, Meritxell Nus, Miquel Navas-Madroñal, Joan Fité, Belén Pérez, Antonio J Barros-Membrilla, Begoña Soto, José Martínez-González, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, María Galán
Apr 19, 2021
Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good...
Use of Blumensaat's line for assessment of cranial tibial subluxation in dogs with cranial cruciate ligament deficiency
Sebastian Prior, Francisco Silveira, Lida Pappa, Pablo Pérez López, Robert Quinn, Darren Barnes
Apr 23, 2022
Abstract: Background: This study aimed to determine whether Blumensaat's line, a consistently present radiographic feature delineating the peak of the femoral intercondylar fossa, could be used to assess for cranial tibial...
The relationship between executive functions and fluid intelligence in euthymic Bipolar Disorder patients.
Belén Goitia, Facundo Manes, Teresa Torralva, Mariano Sigman, John Duncan, Marcelo Cetkovich, María Roca
Apr 11, 2018
Distinct cognitive deficits have been described in Bipolar disorder (BD), including executive impairments, commonly attributed to frontal dysfunction. However, recent attention has been paid to the heterogeneity of cognitive...
Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients.
Sara Ruiz-Pinto, Guillermo Pita, Miguel Martín, Teresa Alonso-Gordoa, Daniel R Barnes, María R Alonso, Belén Herraez, Purificación García-Miguel, Javier Alonso, Antonio Pérez-Martínez, Antonio J Cartón, Federico Gutiérrez-Larraya, José A García-Sáenz, Javier Benítez, Douglas F Easton, Ana Patiño-García, Anna González-Neira
Jan 30, 2018
PURPOSE: Anthracyclines are widely used chemotherapeutic drugs that can cause progressive and irreversible cardiac damage and fatal heart failure. Several genetic variants associated with anthracycline-induced cardiotoxicity...
Anthracyclines Chronic cardiotoxicity ETFB Long-term cancer survivors Low-frequency variants Adult Aged Anthracyclines Breast Neoplasms Cancer Survivors Cardiotoxicity Electron-Transferring Flavoproteins Exome Female Gene Expression Regulation Neoplastic Genetic Association Studies Genetic Predisposition to Disease Heart Failure Humans Middle Aged Mitochondria
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Sep 08, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2...
Animals Aortic Valve Bone Marrow Transplantation Bone Morphogenetic Protein 2 Calcinosis Cell Lineage Chondrogenesis Endothelial Cells Hematopoiesis Hematopoietic Stem Cells Kaplan-Meier Estimate Mice Inbred C57BL Mice Transgenic Muscle Cells Ossification Heterotopic Osteogenesis Receptor TIE-2 Tomography X-Ray Computed
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Aug 26, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2...
Published by: Cell Death & Disease
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Jul 28, 2021
Abstract: Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which...
The relationship between executive functions and fluid intelligence in multiple sclerosis.
Belén Goitia, Diana Bruno, Sofía Abrevaya, Lucas Sedeño, Agustín Ibáñez, Facundo Manes, Mariano Sigman, Vladimiro Sinay, Teresa Torralva, John Duncan, María Roca
Jun 26, 2020
BACKGROUND & OBJECTIVE: Deficits in cognitive functions dependent upon the integrity of the prefrontal cortex have been described in Multiple Sclerosis (MS). In a series of studies we have shown that fluid intelligence (g) is a...
Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality
Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling....
Joint recording of EEG and audio signals in hyperscanning and pseudo-hyperscanning experiments.
Hyperscanning is an emerging technique that allows for the study of brain similarities between interacting individuals. This methodology has powerful implications for understanding the neural basis of joint actions, such as...
Light attenuation in photobioreactors and algal pigmentation under different growth conditions – model identification and complexity assessment
Microalgae are photosynthetic organisms, and thus one of the most important factors affecting their growth is light. Yet, effective design and operation of algal cultivation systems still lacks robust numerical tools. Here, a...
Occupation times of refracted Lévy processes
A refracted Lévy process is a Lévy process whose dynamics change by subtracting off a fixed linear drift (of suitable size) whenever the aggregate process is above a pre-specified level. More precisely, whenever it exists, a...
A Radial Estimation-of-Distribution Algorithm for the Job-Shop Scheduling Problem
Ricardo Pérez-Rodríguez
Jan 01, 2022
The job-shop environment has been widely studied under different approaches. It is due to its practical characteristic that makes its research interesting. Therefore, the job-shop scheduling problem continues being attracted to...
Published by: IGI Global Scientific Publishing
A re-examination of responding on ratio and regulated-probability interval schedules.
The higher response rates observed on ratio than on matched interval reward schedules has been attributed to the differential reinforcement of longer inter-response times (IRTs) on the interval contingency. Some data, however...
A systematic review of the uses and spread of corpora and data-driven learning in CALL research during 2011–2015
Pascual Pérez-Paredes
Nov 21, 2019
This research uses the theoretical framework of CALL normalisation developed by Bax (2003) and Chambers and Bax (2006) to offer a systematic review (Gough et al., 2012) of the uses and spread of data-driven learning (DDL) and...
Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other intracellular organelles, this forms a...
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