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Approaches to treat pulmonary arterial hypertension by targeting BMPR2
Pulmonary arterial hypertension (PAH) is estimated to affect between 10 and 50 people per million worldwide. The lack of cure and devastating nature of the disease means that treatment is crucial to arrest rapid clinical...
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.
Benjamin J Dunmore, Kylie M Drake, Paul D Upton, Mark R Toshner, Micheala A Aldred, Nicholas W Morrell
Apr 06, 2020
Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations in the bone morphogenetic protein receptor...
Bone Morphogenetic Protein Receptors Type II Cell Line Cell Membrane Cells Cultured Chloroquine Endothelial Cells Familial Primary Pulmonary Hypertension Growth Differentiation Factor 2 Growth Differentiation Factors Humans Hypertension Pulmonary Lysosomes Mutation Pulmonary Artery RNA Small Interfering Signal Transduction Smad Proteins Transcription Genetic
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Lu Long, Xudong Yang, Mark Southwood, Junyu Lu, Stefan J Marciniak, Benjamin J Dunmore, Nicholas W Morrell
Sep 20, 2018
RATIONALE: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation and apoptosis resistance in pulmonary artery smooth muscle cells (PASMCs). OBJECTIVE: We reasoned that chloroquine, based on its...
MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms.
Muna Affara, Benjamin J Dunmore, Deborah A Sanders, Nicola Johnson, Cristin G Print, D Stephen Charnock-Jones
Jun 16, 2011
Cells Cultured Chromatin Immunoprecipitation Female GATA3 Transcription Factor Humans Immunoblotting Inflammation Mediators Interleukin-1beta Interleukin-8 Matrix Metalloproteinase 1 Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Protein Binding Proto-Oncogene Protein c-ets-1 Proto-Oncogene Protein c-ets-2 Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha
“He Was the One With the Gun!” Associative Memory for White and Black Faces Seen With Weapons
Much research has found that implicit associations between Black male faces and aggression afect dispositional judgments and decision-making, but there have been few investigations into downstream efects on explicit episodic...
Published by: Digital Commons @ Texas A&M University-San Antonio
A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J Stewart, Nicholas W Morrell
Aug 09, 2018
Endothelium Exosomes Hypertension pulmonary remodeling Animals Apoptosis Biomarkers Tumor Bone Morphogenetic Protein Receptors Type II Cell Movement Cell Proliferation Cell Shape Disease Models Animal Endothelial Cells Exosomes Humans Hypertension Pulmonary Lentivirus Lung Male Monocrotaline Mutation Myocytes Smooth Muscle Protein Transport Pulmonary Artery Rats Sprague-Dawley Tumor Protein Translationally-Controlled 1 Vascular Remodeling
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Richard P Hayhoe, Cristin G Print, Simon J Cook, Edwin R Chilvers
Jun 19, 2018
Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis...
Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Caspase 9 Cell Survival Gene Expression Regulation Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Inflammation Membrane Proteins Microscopy Confocal Models Biological Neutrophils Phenotype Pneumonia Proto-Oncogene Proteins Tumor Necrosis Factor-alpha
Caveolae protect endothelial cells from membrane rupture during increased cardiac output.
Jade PX Cheng, Carolina Mendoza-Topaz, Gillian Howard, Jessica Chadwick, Elena Shvets, Andrew S Cowburn, Benjamin J Dunmore, Alexi Crosby, Nicholas W Morrell, Benjamin J Nichols
Jun 19, 2018
Caveolae are strikingly abundant in endothelial cells, yet the physiological functions of caveolae in endothelium and other tissues remain incompletely understood. Previous studies suggest a mechanoprotective role, but whether...
Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.
Muna Affara, Debbie Sanders, Hiromitsu Araki, Yoshinori Tamada, Benjamin J Dunmore, Sally Humphreys, Seiya Imoto, Christopher Savoie, Satoru Miyano, Satoru Kuhara, David Jeffries, Cristin Print, D Stephen Charnock-Jones
Apr 06, 2020
BACKGROUND: Apoptosis is a critical process in endothelial cell (EC) biology and pathology, which has been extensively studied at protein level. Numerous gene expression studies of EC apoptosis have also been performed, however...
Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.
Fedir N Kiskin, C-Hong Chang, Christopher JZ Huang, Baraa Kwieder, Christine Cheung, Benjamin J Dunmore, Felipe Serrano, Sanjay Sinha, Nicholas W Morrell, Amer A Rana
Jun 14, 2018
Professor and Columbia Judge-Alumna Selected as Liberty Fellows
Winthrop University
Jan 01, 0001
The 23 Liberty Fellows are described as action-oriented leaders with ambitious goals for a stronger South Carolina and were selected from more than 400 nominations from across the state. Chosen as Winthrop Fellows are: DeAndrea...
Published by: Winthrop University
Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension
Lu Long, Xudong Yang, Mark Southwood, Stephen Moore, Alexi Crosby, Paul D. Upton, Benjamin J. Dunmore, Nicholas W. Morrell
Jul 21, 2020
Pulmonary arterial hypertension is a fatal disorder of the lung circulation in which accumulation of vascular cells progressively obliterates the pulmonary arterioles. This results in sustained elevation in pulmonary artery...
Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients.
Benjamin J Dunmore, Paul D Upton, Kate Auckland, Romit J Samanta, Paul A Lyons, Kenneth G C Smith, Stefan Gräf, Charlotte Summers, Nicholas W Morrell
Mar 03, 2023
Similar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID-19) is characterized by the aberrant expression of vascular injury biomarkers. We present the first report that circulating plasma...
Published by: Pulmonary circulation
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Jun 14, 2018
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is...
Adult Animals Cell Differentiation Cell Line Cluster Analysis Embryonic Stem Cells Endothelial Cells Fetus Gene Expression Profiling Gene Ontology Genes Homeobox Homeodomain Proteins Humans Lung Mice Neovascularization Physiologic Oligonucleotide Array Sequence Analysis Organ Specificity Phenotype Pulmonary Artery RNA Messenger Rats Real-Time Polymerase Chain Reaction Reproducibility of Results
4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension.
Benjamin J Dunmore, Xudong Yang, Alexi Crosby, Stephen Moore, Lu Long, Christopher Huang, Mark Southwood, Eric D Austin, Amer Rana, Paul D Upton, Nicholas W Morrell
Apr 06, 2020
Mutations in the gene encoding BMPR2 (bone morphogenetic protein type 2 receptor) are the major cause of heritable pulmonary arterial hypertension (PAH). Point mutations in the BMPR2 ligand-binding domain involving cysteine...
Hypertension Mutation pulmonary Treatment Animals Bone Morphogenetic Protein Receptors Type II Cell Proliferation Cells Cultured Cysteine Humans Mice Muscle Smooth Vascular Mutation Myocytes Smooth Muscle Organophosphorus Compounds pulmonary arterial hypertension Pulmonary Artery Signal Transduction Vascular Remodeling
Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.
Alexi Crosby, Mark R Toshner, Mark R Southwood, Elaine Soon, Benjamin J Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert, Nicholas W Morrell
Nov 15, 2018
Increasing evidence suggests that patients with pulmonary arterial hypertension (PAH) demonstrate abnormalities in the bone marrow (BM) and hematopoietic progenitor cells. In addition, PAH is associated with myeloproliferative...
Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.
Ionel Sandovici, Constanze M Hammerle, Wendy N Cooper, Noel H Smith, Jane L Tarry-Adkins, Benjamin J Dunmore, Julien Bauer, Simon R Andrews, Giles SH Yeo, Susan E Ozanne, Miguel Constância
Sep 12, 2016
Ageing DNA Methylation epigenetics Inflammageing Pancreatic islets Type 2 diabetes aging Animals Chemokine CXCL9 Collagen Type III DNA Methylation Diabetes mellitus Type 2 Epigenesis Genetic Inflammation Islets of Langerhans KCNQ1 Potassium Channel Male Phosphoric Diester Hydrolases Pyrophosphatases Rats Sulfonylurea Receptors Tetraspanins
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Nov 08, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
Dance Major from Lugoff, S.C., Earned Tillman Award
Winthrop University
Jan 01, 0001
Amanda Floyd earned a Bachelor of Arts degree in dance and wants to teach dance with the ultimate goal of working in choreography. The Tillman Award is the university's highest academic honor. Established in 1940 to honor former...
Published by: Winthrop University
Business Major Tapped as Tillman Award Recipient
Winthrop University
Jan 01, 0001
The Tillman Award is the university's highest academic honor. Established in 1940 to honor former S.C. Governor Benjamin Ryan Tillman, the award recognizes the graduate who has most consistently met the demands of academic...
Published by: Winthrop University
Interview with Julia Mobley Irwin
Julia Mobley Irwin
Jan 01, 0001
In her November 9, 1976 interview with Sally Tyler, Julia Mobley Irwin details her life as a day student in the early 1900s. Irwin recalls her favorite classes, describes uniforms, insists that there was never a swimming pool at...
Day Student uniforms Latin Class Winthrop Training School Graduation Swimming Pool Benjamin Tillman Class of 1904 Oral History
Published by: Winthrop University
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
Hannah J Durrington, Paul D Upton, Simon Hoer, Jessica Boname, Benjamin J Dunmore, Jun Yang, Trina K Crilley, Lynn M Butler, David J Blackbourn, Gerard B Nash, Paul J Lehner, Nicholas W Morrell
Aug 28, 2020
Bone morphogenetic proteins (BMPs) are critically involved in early development and cell differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor (BMPR-II) is associated with pulmonary arterial...
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Dec 09, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
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