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Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies.
Historically tools and technologies facilitated scientific discoveries. Steroid hormone research is not an exception. Unfortunately, the dramatic advancement of the field faded this research area and flagged it as a solved...
An atlas of mouse CD4(+) T cell transcriptomes.
Michael JT Stubbington, Bidesh Mahata, Valentine Svensson, Andrew Deonarine, Jesper K Nissen, Alexander G Betz, Sarah A Teichmann
May 16, 2019
BACKGROUND: CD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of...
Alternative Splicing Animals Cell Differentiation Cluster Analysis Flow Cytometry Gene Expression Profiling Gene Expression Regulation Immune System Mice Mice Inbred C57BL principal component analysis Protein Isoforms RNA Messenger Sequence Analysis RNA Signal Transduction T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Th17 Cells Transcriptome Up-Regulation
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A Haniffa, Jacqueline D Shields, Sarah A Teichmann
May 01, 2020
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.
Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L Hennrich, Anne-Claude Gavin, Steven V Ley, Sarah A Teichmann
May 13, 2021
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B Meyer, Zhichao Miao, Andrew NJ McKenzie, Bidesh Mahata, Sarah A Teichmann
May 14, 2019
BACKGROUND: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory...
Genome-wide XBP1 chromatin occupancy IRE1a IRE1a-XBP1 pathway RNA-seq T helper cell activation Th2 lymphocyte proliferation Th2 transcriptome xbp1 XBP1 ChIP-seq Animals Base Sequence Cell Cycle Cell Differentiation Cell Proliferation Cytokines Endoribonucleases Female Gene Expression Regulation Genome-Wide Association Study Lymphocyte Activation Mice Inbred C57BL Mice Transgenic Protein Serine-Threonine Kinases Signal Transduction Stress Physiological Th2 Cells Up-Regulation X-Box Binding Protein 1
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 28, 2021
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann
Jul 30, 2020
Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Role of clathrin in dense core vesicle biogenesis
BS Sahu, PT Manna, JR Edgar, R Antrobus, SK Mahata, A Bartolomucci, GHH Borner, MS Robinson
Oct 05, 2017
Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules.
Anup Parchure, Meng Tian, Danièle Stalder, Cierra K Boyer, Shelby C Bearrows, Kristen E Rohli, Jianchao Zhang, Felix Rivera-Molina, Bulat R Ramazanov, Sushil K Mahata, Yanzhuang Wang, Samuel B Stephens, David C Gershlick, Julia von Blume
Oct 30, 2022