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Results: 146
An implementation research agenda.
Martin P Eccles, David Armstrong, Richard Baker, Kevin Cleary, Huw Davies, Stephen Davies, Paul Glasziou, Irene Ilott, Ann-Louise Kinmonth, Gillian Leng, Stuart Logan, Theresa Marteau, Susan Michie, Hugh Rogers, Jo Rycroft-Malone, Bonnie Sibbald
Jun 14, 2011
In October 2006, the Chief Medical Officer (CMO) of England asked Professor Sir John Tooke to chair a High Level Group on Clinical Effectiveness in response to the chapter 'Waste not, want not' in the CMOs 2005 annual report 'On...
Germline BRCA mutation and outcome in young-onset breast cancer (POSH)
Ellen R Copson, Tom C Maishman, Will J Tapper, Ramsey I Cutress, Stephanie Greville-Heygate, Douglas G Altman, Bryony Eccles, Sue Gerty, Lorraine T Durcan, Louise Jones, D Gareth Evans, Alastair M Thompson, Paul Pharoah, Douglas F Easton, Alison M Dunning, Andrew Hanby, Sunil Lakhani, Ros Eeles, Fiona J Gilbert, Hisham Hamed, Shirley Hodgson, Peter Simmonds, Louise Stanton, Diana M Eccles
Feb 02, 2018
BACKGROUND: Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the effect of a...
Adult Age Factors Breast Neoplasms Cohort Studies Combined Modality Therapy Disease-Free Survival Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Germ-Line Mutation Humans Multivariate Analysis Patient Outcome Assessment Prognosis Proportional Hazards Models Prospective Studies Survival Analysis Triple Negative Breast Neoplasms United Kingdom Young Adult
Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols
The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release...
Understanding of BRCA VUS genetic results by breast cancer specialists.
BACKGROUND: Mainstreaming genetic medicine, increased media coverage and clinical trials for BRCA mutation carriers are leading oncologists into more patient discussions about BRCA genetic testing. BRCA variants of uncertain...
Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols
The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release...
The use of thaumatin and bovine serum albumin as proteins in model wine solutions in bentonite fining
This study examined the viability of using thaumatin and bovine serum albumin (BSA) as proteins in model wine solutions for bentonite fining studies and compared them with unfined New Zealand sauvignon blanc (SB) wine. Bentonite...
Investigating the feasibility of using polysulfone-montmorillonite composite membranes for protein adsorption
The feasibility of immobilisation of montmorillonite (MMT) in polysulfone (PSf) to form mixed matrix membrane (PSf/MMT) to serve as the adsorbent for BSA proteins from a model wine solution was investigated. Pristine PSf and...
Developing strategic recommendations for implementing smart pumps in advanced healthcare systems to improve intravenous medication safety
Adam Sutherland, Matthew Jones, Moninne Howlett, Sara Arenas-Lopez, Arif Patel, Bryony Dean Franklin
Aug 31, 2022
Avoidable harm associated with medication is a persistent problem in health systems and the use of preprogrammed infusion devices (‘smart pumps’) and data monitoring is seen as a core approach to mitigating and reducing the...
Investigating the feasibility of using polysulfone-montmorillonite composite membranes for protein adsorption
The feasibility of immobilisation of montmorillonite (MMT) in polysulfone (PSf) to form mixed matrix membrane (PSf/MMT) to serve as the adsorbent for BSA proteins from a model wine solution was investigated. Pristine PSf and...
Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C−O Bond Formation
Susana Estopina-Duran, Liam Donnelly, Euan Mclean, Bryony Hockin, Alexandra M.Z. Slawin, James Taylor
Mar 12, 2019
A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C‐O bonds. This method has been applied to the intermolecular...
Assessing general cognitive and adaptive abilities in adults with Down syndrome
Sarah Hamburg, Bryony Lowe, Carla Marie Startin, Concepcion Padilla, Antonia Coppus, Wayne Silverman, Juan Fortea, Shahid Zaman, Elizabeth Head, Benjamin L Handen, Ira Lott, Weihong Song, André Strydom
Aug 29, 2020
BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on...
The bridge-like lipid transfer protein (BLTP) gene group
The HUGO Gene Nomenclature Committee assigns unique symbols and names to human genes. The use of approved nomenclature enables effective communication between researchers, and there are multiple examples of how the usage of...
Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C−O Bond Formation
Susana Estopina-Duran, Liam Donnelly, Euan Mclean, Bryony Hockin, Alexandra M.Z. Slawin, James Taylor
Mar 12, 2019
A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C‐O bonds. This method has been applied to the intermolecular...
The use of thaumatin and bovine serum albumin as proteins in model wine solutions in bentonite fining
This study examined the viability of using thaumatin and bovine serum albumin (BSA) as proteins in model wine solutions for bentonite fining studies and compared them with unfined New Zealand sauvignon blanc (SB) wine. Bentonite...
Developing strategic recommendations for implementing smart pumps in advanced healthcare systems to improve intravenous medication safety
Adam Sutherland, Matthew Jones, Moninne Howlett, Sara Arenas-Lopez, Arif Patel, Bryony Dean Franklin
Aug 31, 2022
Avoidable harm associated with medication is a persistent problem in health systems and the use of preprogrammed infusion devices (‘smart pumps’) and data monitoring is seen as a core approach to mitigating and reducing the...
The importance of being the HGNC.
Elspeth A Bruford, Bryony Braschi, Liora Haim-Vilmovsky, Tamsin EM Jones, Ruth L Seal, Susan Tweedie
Nov 15, 2022
The HUGO Gene Nomenclature Committee (HGNC) has been providing standardized symbols and names for human genes since the late 1970s. As funding agencies change their priorities, finding financial support for critical biomedical...
Teachers' views on the acceptability and implementation of the Incredible Years® Teacher Classroom Management programme in English (UK) primary schools from the STARS trial.
Kate Allen, Lorraine Hansford, Rachel Hayes, Bryony Longdon, Matthew Allwood, Anna Price, Sarah Byford, Brahm Norwich, Tamsin Ford
Mar 11, 2022
Consensus nomenclature for dyneins and associated assembly factors.
Bryony Braschi, Heymut Omran, George B Witman, Gregory J Pazour, K Kevin Pfister, Elspeth A Bruford, Stephen M King
Feb 10, 2022
Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and...
Promoting Physical Activity Policy
Kate Oldridge-Turner, Margarita Kokkorou, Fiona Sing, Knut-Inge Klepp, Harry Rutter, Arnfinn Helleve, Bryony Sinclair, Louise Meincke, Giota Mitrou, Martin Wiseman, Kate Allen
Apr 30, 2022
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