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Direct core functionalisation of naphthalenediimides by iridium catalysed C–H borylation
Catherine L. Lyall, Camilla C. Shotton, Monserrat Pérez-salvia, Dan Pantos, Simon E. Lewis
Nov 18, 2014
We report the first boron-substituted naphthalenediimides (NDIs), prepared by iridium catalysed C–H activation. When the NDI substrates bear N-benzyl substituents, the naphthyl NDI core is borylated in preference, suggestive of...
Direct core functionalisation of naphthalenediimides by iridium catalysed C–H borylation
Catherine L. Lyall, Camilla C. Shotton, Monserrat Pérez-salvia, Dan Pantos, Simon E. Lewis
Nov 18, 2014
We report the first boron-substituted naphthalenediimides (NDIs), prepared by iridium catalysed C–H activation. When the NDI substrates bear N-benzyl substituents, the naphthyl NDI core is borylated in preference, suggestive of...
The α-tertiary amine motif drives remarkable selectivity for Pd-catalyzed carbonylation of β-methylene C-H bonds.
The selective C-H carbonylation of methylene bonds in the presence of traditionally more reactive methyl C-H and C(sp2)-H bonds in α-tertiary amines is reported. The exceptional selectivity is driven by the bulky α-tertiary...
Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O'Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson
Oct 04, 2021
The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours...
Phosphoinositide 3-kinase beta controls replication factor C assembly and function.
Javier Redondo-Muñoz, María Josefa Rodríguez, Virginia Silió, Vicente Pérez-García, José María Valpuesta, Ana C Carrera
Apr 16, 2019
Genomic integrity is preserved by the action of protein complexes that control DNA homeostasis. These include the sliding clamps, trimeric protein rings that are arranged around DNA by clamp loaders. Replication factor C (RFC)...
Comprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene.
Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Elena Bueno-Martínez, Patricia Llovet, Beatriz Díez-Gómez, María José Caloca, Pedro Pérez-Segura, Eugenia Fraile-Bethencourt, Marta Colmena, Sara Carvalho, Jamie Allen, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Dec 16, 2020
Hereditary breast and/or ovarian cancer is a highly heterogeneous disease with more than 10 known disease-associated genes. In the framework of the BRIDGES project (Breast Cancer Risk after Diagnostic Gene Sequencing), the...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Occupation times of refracted Lévy processes
A refracted Lévy process is a Lévy process whose dynamics change by subtracting off a fixed linear drift (of suitable size) whenever the aggregate process is above a pre-specified level. More precisely, whenever it exists, a...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Occupation times of refracted Lévy processes
A refracted Lévy process is a Lévy process whose dynamics change by subtracting off a fixed linear drift (of suitable size) whenever the aggregate process is above a pre-specified level. More precisely, whenever it exists, a...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape
Anna Sampietro, F Javier Pérez-Areales, Paula Martínez, Elsa M Arce, Carles Galdeano, Diego Muñoz-Torrero
Apr 29, 2022
Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a comprehensive bibliometric analysis of the publications in the period 1990-2020, we have identified trends and potential gaps that might guide...
Comprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene
Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Elena Bueno-Martínez, Patricia Llovet, Beatriz Díez-Gómez, María José Caloca, Pedro Pérez-Segura, Eugenia Fraile-Bethencourt, Marta Colmena, Sara Carvalho, Jamie Allen, Douglas F. Easton, Peter Devilee, Maaike P. G. Vreeswijk, Miguel de la Hoya, Eladio A. Velasco
Dec 22, 2020
Hereditary breast and/or ovarian cancer is a highly heterogeneous disease with more than 10 known disease-associated genes. In the framework of the BRIDGES project (Breast Cancer Risk after Diagnostic Gene Sequencing), the...
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Jun 06, 2020
Abstract: Background and aims: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of...
<i>RAD51D</i> Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Aug 02, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the...
Breast Cancer ovarian cancer susceptibility genes ESE ESS VUS aberrant splicing minigene RAD51D clinical interpretation
Published by: Cancers
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
RAD51D Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Jul 08, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the splicing...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Reducing Passive Drug Diffusion from Electrophoretic Drug Delivery Devices through Co-Ion Engineering.
Shao-Tuan Chen, Megan N Renny, Liliana C Tomé, Jorge L Olmedo-Martínez, Esther Udabe, Elise PW Jenkins, David Mecerreyes, George G Malliaras, Robert R McLeod, Christopher M Proctor
Mar 25, 2021
Implantable electrophoretic drug delivery devices have shown promise for applications ranging from treating pathologies such as epilepsy and cancer to regulating plant physiology. Upon applying a voltage, the devices...
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
Enhancement of the antimicrobial properties of bacteriophage-K via stabilisation using oil-in-water nano-emulsions
Patricia Pérez Esteban, Diana Alves, Mark C. Enright, Jessica E. Bean, Alison Gaudion, A. T. A. Jenkins, Amber E. R. Young, Tom C. Arnot
Aug 01, 2014
Bacteriophage therapy is a promising new treatment that may help overcome the threat posed by antibiotic-resistant pathogenic bacteria, which are increasingly identified in hospitalised patients. The development of biocompatible...
Enhancement of the antimicrobial properties of bacteriophage-K via stabilisation using oil-in-water nano-emulsions
Patricia Pérez Esteban, Diana Alves, Mark C. Enright, Jessica E. Bean, Alison Gaudion, A. T. A. Jenkins, Amber E. R. Young, Tom C. Arnot
Aug 01, 2014
Bacteriophage therapy is a promising new treatment that may help overcome the threat posed by antibiotic-resistant pathogenic bacteria, which are increasingly identified in hospitalised patients. The development of biocompatible...
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease.
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Dec 12, 2020
BACKGROUND AND AIMS: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT...
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