Search
Results: 21860
Identifying the immune interactions underlying HLA class I disease associations
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang
May 28, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
Multiphysics computational modeling in <i>C</i>Heart
J. Lee, A. Cookson, I. Roy, E. Kerfoot, L. Asner, G. Vigueras, T. Sochi, S. Deparis, C. Michler, N. P. Smith, D. A. Nordsletten
May 26, 2016
From basic science to translation, modern biomedical research demands computational models which integrate several interacting physical systems. This paper describes the infrastructural framework for generic multiphysics...
Multiphysics computational modeling in <i>C</i>Heart
J. Lee, A. Cookson, I. Roy, E. Kerfoot, L. Asner, G. Vigueras, T. Sochi, S. Deparis, C. Michler, N. P. Smith, D. A. Nordsletten
May 26, 2016
From basic science to translation, modern biomedical research demands computational models which integrate several interacting physical systems. This paper describes the infrastructural framework for generic multiphysics...
Identifying the immune interactions underlying HLA class I disease associations.
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith
Jun 19, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
Exploring Eco-Innovation Barriers to the Sustainability Transition in Cold Chain E-Fulfilment Systems
The growing demand for cold chain e-fulfilment services has created challenges for implementing low-carbon practices due to the use of extensive energy and insulation materials required to maintain the desired service quality...
Published by: IGI Global Scientific Publishing
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease
Julian C van Capelleveen, Andrea E Bochem, S Matthijs Boekholdt, Samia Mora, Ron C Hoogeveen, Christie M Ballantyne, Paul M Ridker, Wensheng Sun, Philip J Barter, Alan R Tall, Aeilko H Zwinderman, John JP Kastelein, Nick J Wareham, Kay-Tee Khaw, G Kees Hovingh
Mar 22, 2018
BACKGROUND: The contribution of apolipoprotein A-I (apoA-I) to coronary heart disease (CHD) risk stratification over and above high-density lipoprotein cholesterol (HDL-C) is unclear. We studied the associations between plasma...
apolipoprotein A‐I cardiovascular disease coronary heart disease high‐density lipoprotein cholesterol Aged Antineoplastic Agents Apolipoprotein A-I Aspirin Cardiovascular Diseases Cholesterol HDL Coronary Disease Double-Blind Method England Female Humans Kaplan-Meier Estimate Male Middle Aged Neoplasms Platelet Aggregation Inhibitors Prognosis Prospective Studies Risk Factors Vitamin E Women's Health
New Data on Comparative Cytogenetics of the Mouse-Like Hamsters (<i>Calomyscus</i> Thomas, 1905) from Iran and Turkmenistan.
Svetlana A Romanenko, Vladimir G Malikov, Ahmad Mahmoudi, Feodor N Golenishchev, Natalya A Lemskaya, Jorge C Pereira, Vladimir A Trifonov, Natalia A Serdyukova, Malcolm A Ferguson-Smith, Mansour Aliabadian, Alexander S Graphodatsky
Aug 02, 2021
The taxonomy of the genus Calomyscus remains controversial. According to the latest systematics the genus includes eight species with great karyotypic variation. Here, we studied karyotypes of 14 Calomyscus...
Karyotype Chromosome Painting banding fluorescent in situ hybridization type locality Molecular cytogenetics painting probes
Published by: Genes
Dicopper(I) Complexes Incorporating Acetylide-functionalized Pyridinyl-based Ligands:
Jayapal Maharaja, Ashanul Haque, Idris Juma Al-Busaidi, Nawal A-Rasbi, Mohammed K Al-Suti, Muhammad S Khan, Rayya A. Al-balushi, Shahidul Islam, Chenghao Xin, Wenjun Wu, Wai-Yeung Wong, Frank Marken, Paul Raithby
Oct 01, 2018
Hetero-aryl incorporated acetylide-functionalized pyridinyl ligands (L1-6) with the general formula Py-C≡C-Ar (Py = pyridine and Ar = thiophene-2-yl, 2,2'-bithiophene]-5-yl, 2,2':5',2''-terthiophene]-5-yl...
Dicopper(I) Complexes Incorporating Acetylide-functionalized Pyridinyl-based Ligands:
Jayapal Maharaja, Ashanul Haque, Idris Juma Al-Busaidi, Nawal A-Rasbi, Mohammed K Al-Suti, Muhammad S Khan, Rayya A. Al-balushi, Shahidul Islam, Chenghao Xin, Wenjun Wu, Wai-Yeung Wong, Frank Marken, Paul Raithby
Oct 01, 2018
Hetero-aryl incorporated acetylide-functionalized pyridinyl ligands (L1-6) with the general formula Py-C≡C-Ar (Py = pyridine and Ar = thiophene-2-yl, 2,2'-bithiophene]-5-yl, 2,2':5',2''-terthiophene]-5-yl...
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer
Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H Palmer, Yuk Ting Ma, TR Jeff Evans, Duncan RC Spalding, Madhava Pai, Rohini Sharma, David J Pinato, James Spicer, Sarah Hunter, Vineet Kwatra, Joanna P Nicholls, David Collin, Robert Nutbrown, Helen Glenny, Sonia Fairbairn, Vikash Reebye, Jon Voutila, Stephanie Dorman, Pinelopi Andrikakou, Peter Lloyd, Steve Felstead, Jenni Vasara, Robert Habib, Chris Wood, Pal Saetrom, Hans E Huber, David C Blakey, John J Rossi, Nagy Habib
May 13, 2020
PURPOSE: Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA...
Adult Aged Aged 80 and over Antineoplastic Agents CCAAT-Enhancer-Binding Proteins Carcinoma Hepatocellular Dose-Response Relationship Drug Female Gene Expression Regulation Neoplastic Humans Infusions Intravenous Liposomes Liver Neoplasms Male Middle Aged Nanoparticles Neoplasm Staging Oligoribonucleotides Treatment Outcome Tumor Microenvironment Up-Regulation
Light Sheet Microscopy and Image Analysis of Neural Development and Programmed Cell Death in C. Elegans Embryos
Peter Insley
Jan 01, 0001
The positioning of neuronal cell bodies and neurites is critical for intact functioning of the nervous system. Mapping the positions of the soma and neurites in the brains of developing embryos as important central nervous...
Published by: Rockefeller University
Molecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Mar 28, 2023
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular...
ovarian cancer Hereditary cancer Whole exome sequencing TCGA Fanci Fanconi Anemia Pathway Cancer Predisposing Gene Humans Ovarian Neoplasms Genetic Predisposition to Disease Molecular Biology Mutation Genes BRCA2 Female Fanconi Anemia Complementation Group Proteins
Published by: Genes
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Intelligent E-Vendor Relationship Management for Enhancing Global B2C E-Commerce Ecosystems
Recently, global e-commerce businesses have been blooming due to the convenience they offer, their product range, and the individualized products and services they offer. To maintain an entire ecosystem, effective...
Published by: IGI Global Scientific Publishing
Search for the doubly heavy baryons Ω<inf>bc</inf><sup>0</sup>and Ξ<inf>bc</inf><sup>0</sup>decaying to Λ<inf>c</inf><sup>+</sup>π- And Ξ<inf>c</inf><sup>+</sup>π- And c
C Nguyen-Mau, R Aaij, C Abellán Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, G Alkhazov, P Alvarez Cartelle, S Amato, Y Amhis, L An, L Anderlini, A Andreianov, M Andreotti, F Archilli, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, M Bachmayer, JJ Back, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista Leite, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, JM Basels, G Bassi, B Batsukh, A Battig, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, V Belavin, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, I Bezshyiko, S Bhasin, J Bhom, L Bian, MS Bieker, S Bifani, P Billoir, M Birch, FCR Bishop, A Bitadze, A Bizzeti, M Bj rn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, JA Boelhauve, O Boente Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, SA Bouchiba, TJV Bowcock, A Boyer, C Bozzi, MJ Bradley
Aug 31, 2021
The first search for the doubly heavy $\it{\Omega}_{bc}^{\rm0}$ baryon and a
search for $\it{\Xi}_{bc}^{\rm0}$ baryon are performed using $pp$ collision
data collected via the LHCb experiment from 2016 to 2018 at a...
An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
Jin Xiao, Wangzhen Xiang, Yongli Zhang, Weiyu Peng, Min Zhao, Ling Niu, Yan Chai, Jianxun Qi, Fei Wang, Peng Qi, Chungang Pan, Lingxia Han, Ming Wang, Jim Kaufman, George F Gao, William J Liu
Dec 17, 2018
MHC molecules are found in all jawed vertebrates and are known to present peptides to T lymphocytes. In mammals, peptides can hang out either end of the peptide-binding groove of classical class II molecules, whereas the N and C...
<i>RAD51D</i> Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Aug 02, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the...
Breast Cancer ovarian cancer susceptibility genes ESE ESS VUS aberrant splicing minigene RAD51D clinical interpretation
Published by: Cancers
Naturalism<i>in extremis</i>
Claire White
Oct 08, 2015
Exploring the Impact of Terminators on Transgene Expression in <i>Chlamydomonas reinhardtii</i> with a Synthetic Biology Approach.
Katrin Geisler, Mark A Scaife, Paweł M Mordaka, Andre Holzer, Eleanor V Tomsett, Payam Mehrshahi, Gonzalo I Mendoza Ochoa, Alison G Smith
Oct 29, 2021
Chlamydomonas reinhardtii has many attractive features for use as a model organism for both fundamental studies and as a biotechnological platform. Nonetheless, despite the many molecular tools and resources that have...
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
|
|< |
< |
1 |