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The Accuracy and Validity of the Simplified Pairs Method of Comparative Judgement in Highly Structured Papers
Comparative judgement (CJ) is often said to be more suitable for judging exam questions inviting extended responses, as it is easier for judges to make holistic judgements on a small number of large, extended tasks than...
Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells
Cedric Ghevaert
Mar 19, 2022
Platelet deficiency, known as thrombocytopenia, can cause haemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells,
megakaryocytes, from pluripotent stem...
A Mathematical Model of a Valve-Controlled Bioreactor for Platelet Production
As blood donor numbers decrease, while demand for platelets increases, hospitals worldwide are becoming increasingly vulnerable to critical platelet shortages. Alternative methods of supplying platelets are therefore...
A Mathematical Model of a Valve-Controlled Bioreactor for Platelet Production
As blood donor numbers decrease, while demand for platelets increases, hospitals worldwide are becoming increasingly vulnerable to critical platelet shortages. Alternative methods of supplying platelets are therefore...
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP.
Moyra Lawrence, Amanda Evans, Thomas Moreau, Marta Bagnati, Matthew Smart, Enas Hassan, Jahid Hasan, Monica Pianella, Julie Kerby, Cedric Ghevaert
Jun 27, 2021
Quality, traceability and reproducibility are crucial factors in the reliable manufacture of cellular therapeutics, as part of the overall framework of Good Manufacturing Practice (GMP). As more and more cellular therapeutics...
Published by: NPJ Regenerative medicine
Exploring the Validity of Comparative Judgement
When completing a comparative judgment (CJ) exercise, judges are asked to make holistic decisions about the quality of the work they are comparing. A key consideration is the validity of expert judgements. This article...
Characterizing optimal sampling of binary contingency tables via the configuration model
A binary contingency table is an m × n array of binary entries with row sums r = (r1,..., rm) and column sums c = (c1,..., cn). The configuration model generates a contingency table by considering ri tokens of type 1 for each...
Characterizing optimal sampling of binary contingency tables via the configuration model
A binary contingency table is an m × n array of binary entries with row sums r = (r1,..., rm) and column sums c = (c1,..., cn). The configuration model generates a contingency table by considering ri tokens of type 1 for each...
Adjusting for cross-cultural differences in computer-adaptive tests of quality of life.
PURPOSE: Previous studies using the WHOQOL measures have demonstrated that the relationship between individual items and the underlying quality of life (QoL) construct may differ between cultures. If unaccounted for, these...
Tetrahedral intrinsic structure of Oxygen-16 revisited
Abstract
A model for vibrational and rotational excitations of an intrinsic tetrahedral structure of the Oxygen-16 nucleus has been investigated, building on classic work of...
Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes
Jennifer H Shepherd, Daniel Howard, Amie K Waller, Holly Rebecca Foster, Annett Mueller, Thomas Moreau, Amanda L Evans, Meera Arumugam, Guénaëlle Bouët Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M Best, Ruth E Cameron
Nov 08, 2018
Bioreactor Bone marrow model Collagen Depth straining Forward programming Human induced pluripotent stem cells interconnectivity Megakaryocytes Parallel flow membrane filter platelets scaffold architecture Settling zones shear flow Biocompatible Materials Bioreactors Blood Platelets Cell Culture Techniques Cells Cultured Collagen Equipment Design Humans Megakaryocytes Pluripotent Stem Cells Thrombopoiesis Tissue Scaffolds
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