Search
Results: 66
Rapid identification of genes controlling virulence and immunity in malaria parasites
HM Abkallo, A Martinelli, M Inoue, A Ramaprasad, P Xangsayarath, J Gitaka, J Tang, K Yahata, A Zoungrana, H Mitaka, A Acharjee, PP Datta, P Hunt, R Carter, O Kaneko, V Mustonen, CJR Illingworth, A Pain, R Culleton
Oct 16, 2017
A method to infer positive selection from marker dynamics in an asexual population.
MOTIVATION: The observation of positive selection acting on a mutant indicates that the corresponding mutation has some form of functional relevance. Determining the fitness effects of mutations thus has relevance to many...
Fitness Inference from Short-Read Data
Christopher JR Illingworth
Jul 30, 2015
fitness landscape Influenza Linkage Disequilibrium selection within-host evolution Adaptation Physiological Alleles Animals Biological Evolution evolution Molecular Ferrets Genetic Fitness Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H5N1 Subtype Influenza Human Linkage Disequilibrium Models Genetic Orthomyxoviridae Infections Reassortant Viruses selection Genetic
A novel framework for inferring parameters of transmission from viral sequence data.
Transmission between hosts is a critical part of the viral lifecycle. Recent studies of viral transmission have used genome sequence data to evaluate the number of particles transmitted between hosts, and the role of selection...
A large effective population size for established within-host influenza virus infection.
effective population size evolutionary biology Genetic Drift infectious disease microbiology selection Virus within-host evolution Child Preschool Genetic Drift Genome Viral Humans Immunocompromised Host Infant Influenza B virus Influenza Human Population Density selection Genetic Stochastic Processes whole genome sequencing
Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.
A common challenge arising from the observation of an evolutionary system over time is to infer the magnitude of selection acting upon a specific genetic variant, or variants, within the population. The inference of selection...
Mutational load causes stochastic evolutionary outcomes in acute RNA viral infection.
Mutational load is known to be of importance for the evolution of RNA viruses, the combination of a high mutation rate and large population size leading to an accumulation of deleterious mutations. However, while the effects of...
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
covid-19 FFP3 PPE SARS-CoV-2 EPIDEMIOLOGY Global Health healthcare worker infectious disease mask microbiology viruses Adult Aerosols Aged covid-19 Health Personnel Humans Incidence infection control masks Middle Aged Models Theoretical Respiratory Protective Devices SARS-CoV-2 United Kingdom Young Adult
Evaluating genetic drift in time-series evolutionary analysis.
The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations have commonly been used but the model itself has rarely been tested...
On the effective depth of viral sequence data.
Christopher JR Illingworth, Sunando Roy, Mathew A Beale, Helena Tutill, Rachel Williams, Judith Breuer
May 02, 2018
Genome sequence data are of great value in describing evolutionary processes in viral populations. However, in such studies, the extent to which data accurately describes the viral population is a matter of importance. Multiple...
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers.
Mark Ferris, Rebecca Ferris, Chris Workman, Eoin O'Connor, David A Enoch, Emma Goldesgeyme, Natalie Quinnell, Parth Patel, Jo Wright, Geraldine Martell, Christine Moody, Ashley Shaw, christopher Illingworth, Nicholas Matheson, Michael Weekes
Nov 10, 2021
Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating...
Asymmetrical transfer effects of cognitive bias modification
JO Bowler, L Hoppitt, J Illingworth, T Dalgleish, M Ononaiye, G Perez-Olivas, B Mackintosh
Jan 21, 2020
BACKGROUND AND OBJECTIVES: It is well established that attention bias and interpretation bias each have a key role in the development and continuation of anxiety. How the biases may interact with one another in anxiety is...
Anxiety Attention Cognitive bias modification interpretation Transfer effects Adolescent Analysis of Variance Anxiety Attention Bias Cognition Disorders Cognitive Behavioral Therapy Depression Emotions Feedback Psychological Female Follow-Up Studies Humans Male Psychiatric Status Rating Scales Reaction Time Self Report Surveys and Questionnaires transfer psychology Young Adult
|
|< |
< |
1 |