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The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository
Jason R Taylor, Nitin Williams, Rhodri Cusack, Tibor Auer, Meredith A Shafto, Marie Dixon, Lorraine K Tyler, Cam-CAN, Richard N Henson
Feb 09, 2018
This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a...
Ageing Brain imaging Cognition Data repository Magnetic Resonance Imaging Magnetoencephalography Adolescent Adult Aged Aged 80 and over aging Brain Cognition Cross-Sectional Studies Databases Factual Female Functional Neuroimaging Humans Magnetic Resonance Imaging Magnetoencephalography Male Middle Aged Neurosciences Young Adult
Adult Lifespan Cognitive Variability in the Cross-Sectional Cam-CAN Cohort.
This study examines variability across the age span in cognitive performance in a cross-sectional, population-based, adult lifespan cohort from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (n = 2680). A key...
MMSE adult lifespan ceiling effects cognitive variability Episodic memory Heterogeneity variance confounders verbal fluency Adolescent Adult Aged Aged 80 and over Cognition Cognition Disorders Cognitive Aging Cohort Studies Confounding Factors Epidemiologic Cross-Sectional Studies Female Humans Male Memory Middle Aged Psychological Tests Young Adult
Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort
Objective: We tested the claim that age-related increases in knowledge interfere with word retrieval, leading to word finding failures. We did this by relating a measure of crystallized intelligence to tip-of-the-tongue (TOT)...
Published by: J Gerontol B Psychol Sci Soc Sci
Exploring patterns of response across the lifespan
BACKGROUND: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult...
A watershed model of individual differences in fluid intelligence
Fluid intelligence is a crucial cognitive ability that predicts key life outcomes across the lifespan. Strong empirical links exist between fluid intelligence and processing speed on the one hand, and white matter integrity and...
cognitive ageing Fluid intelligence Processing speed structural equation modelling Watershed model white matter Adolescent Adult Aged Aged 80 and over aging Cohort Studies Endophenotypes Factor Analysis Statistical Female Humans Individuality Intelligence Intelligence Tests Male Middle Aged Models Neurological Models Psychological Reaction Time white matter Young Adult
Visual short-term memory through the lifespan
Visual short-term memory ability falls throughout the lifespan in healthy adults. Using a continuous report task, in a large, population-based sample, we first confirmed that this decline affects the quality and quantity of...
Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.
Rogier A Kievit, Simon W Davis, Daniel J Mitchell, Jason R Taylor, John Duncan, Cam-CAN Research Team, Richard NA Henson, Cam-CAN Research Team
Jun 26, 2018
Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal...
Characterising group-level brain connectivity
The brain can be modelled as a network with nodes and edges derived from a range of imaging modalities: the nodes correspond to spatially distinct regions and the edges to the interactions between them. Whole-brain connectivity...
Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort
interference Knowledge Naming Tip-of-the-tongue (TOT) Word retrieval Adolescent Adult Aged Aged 80 and over Cognitive Aging Cohort Studies Female Humans Intelligence Tests Male Mental Recall Middle Aged pattern recognition Visual Phonetics Psychometrics RECOGNITION psychology Verbal Learning Young Adult
The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol
Dispersion of functional gradients across the adult lifespan.
Richard AI Bethlehem, Casey Paquola, Jakob Seidlitz, Lisa Ronan, Boris Bernhardt, Cam-Can Consortium, Kamen A Tsvetanov
Jan 22, 2021
Ageing is commonly associated with changes to segregation and integration of functional brain networks, but, in isolation, current network-based approaches struggle to elucidate changes across the many axes of functional...
How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
OBJECTIVES: To examine age-related differences in self-reported sleep quality and their associations with health outcomes across four domains: physical health, cognitive health, mental health and neural health. SETTING...
Ageing Cognition Healthy ageing Mental Health physical health sleep quality white matter Adolescent Adult Age Factors Aged Aged 80 and over ANISOTROPY Bayes Theorem Cognition Female health status Humans Male Mental Health Middle Aged prevalence Sleep Sleep Wake Disorders United Kingdom white matter Young Adult
Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter.
Juho M Strömmer, Simon W Davis, Richard N Henson, Lorraine K Tyler, Cam-CAN, Karen L Campbell
Dec 18, 2018
Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed...
brain aging cognitive decline Exercise Adolescent Adult Age Factors Aged Aged 80 and over aging ANISOTROPY Cognition Diffusion Magnetic Resonance Imaging England Exercise Female Frontal Lobe Humans Image Processing Computer-Assisted Male Middle Aged Psychomotor Performance Reaction Time Surveys and Questionnaires white matter
Greater lifestyle engagement is associated with better age-adjusted cognitive abilities.
G Sophia Borgeest, Richard N Henson, Meredith Shafto, David Samu, Cam-CAN, Rogier A Kievit
Jun 23, 2020
Previous evidence suggests that modifiable lifestyle factors, such as engagement in leisure activities, might slow the age-related decline of cognitive functions. Less is known, however, about which aspects of lifestyle might be...
State and Trait Components of Functional Connectivity
Resting-state functional connectivity, as measured by functional magnetic resonance imaging (fMRI), is often treated as a trait, used, for example, to draw inferences about individual differences in cognitive function, or...
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
Greater lifestyle engagement is associated with better age-adjusted cognitive abilities
G. Sophia Borgeest, Richard N. Henson, Meredith Shafto, David Samu, Cam-CAN, Rogier A. Kievit
May 21, 2020
Previous evidence suggests that modifiable lifestyle factors, such as engagement in leisure activities, might slow the age-related decline of cognitive functions. Less is known, however, about which aspects of lifestyle might be...
How parents choose to use CAM
BACKGROUND: Complementary and Alternative Medicine (CAM) is widely used throughout the UK and the Western world. CAM is commonly used for children and the decision-making process to use CAM is affected by numerous factors....
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
The effects of age on resting-state BOLD signal variability is explained by cardiovascular and cerebrovascular factors.
Kamen A Tsvetanov, Richard NA Henson, P Simon Jones, Henk Mutsaerts, Delia Fuhrmann, Lorraine K Tyler, Cam-CAN, James B Rowe
Jan 25, 2021
Accurate identification of brain function is necessary to understand neurocognitive aging, and thereby promote health and well-being. Many studies of neurocognitive aging have investigated brain function with the blood-oxygen...
Cognitive Diversity in a Healthy Aging Cohort
Meredith A Shafto, Richard N Henson, Fiona E Matthews, Jason R Taylor, Tina Emery, Sharon Erzinclioglu, Claire Hanley, James B Rowe, Rhodri Cusack, Andrew J Calder, William D Marslen-Wilson, John Duncan, Tim Dalgleish, Carol Brayne, Cam-CAN, Lorraine K Tyler
Nov 26, 2019
cognitive function Cognitive Reserve healthy aging lifestyle principal components analysis Adolescent Adult Aged Aged 80 and over Cognition Cognitive Aging Cohort Studies Educational Status Female health status healthy aging Humans Life Style longevity Male Middle Aged Social Participation Young Adult
Challenges in measuring individual differences in functional connectivity using fMRI
Many studies report individual differences in functional connectivity, such as those related to age. However, estimates of connectivity from fMRI are confounded by other factors, such as vascular health, head motion and changes...
aging Filtering functional connectivity functional magnetic resonance imaging head motion nuisance regression pre-processing resting state smoothing vascular health Adolescent Adult Aged Aged 80 and over Biological Variation Population Brain Brain Mapping Female Gray Matter Head Movements healthy aging Humans Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Neural Pathways Organ Size Regression Analysis Reproducibility of Results Rest Young Adult
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