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Abnormal placental CD8+ T-cell infiltration is a feature of fetal growth restriction and pre-eclampsia.
Susanne Lager, Ulla Sovio, Elizabeth Eddershaw, Margaretha W van der Linden, Cansu Yazar, Emma Cook, Lisa Happerfield, Flora A Jessop, Neil J Sebire, D Stephen Charnock-Jones, Gordon CS Smith
Sep 11, 2020
Endothelial Cells Fibrin image analysis Leukocytes pathologist scoring Pregnancy complication small-for-gestational age Stereology villitis of unknown aetiology villous tissue CD8-Positive T-Lymphocytes Endothelial Cells Female Fetal Growth Retardation Humans Infant Newborn Placenta pre-eclampsia Pregnancy
Protocol for determining the regulation of lipid kinases and changes in phospholipids in vitro.
Lysosome positioning and mTOR activity in Lowe syndrome.
Lowe syndrome is a rare, developmental disorder caused by mutations in the phosphatase, OCRL. A study in this issue of EMBO Reports shows that OCRL is required for microtubule nucleation and that mutations in this protein lead...
Multimodal Feature Integration in the Angular Gyrus during Episodic and Semantic Retrieval.
AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
AMPK Autophagy PIKfyve Ptdins5P ULK1 glucose starvation AMP-Activated Protein Kinase Kinases Animals Autophagosomes Autophagy-Related Protein-1 Homolog Glucose Humans Intracellular Signaling Peptides and Proteins Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phosphorylation Signal Transduction
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
AMPK PI(5)P PIKfyve ULK1 Autophagy glucose starvation mTOR phagophore AMP-Activated Protein Kinase Kinases Autophagosomes Autophagy Autophagy-Related Protein-1 Homolog Cell Line Gene Expression Regulation Glucose Humans metabolism Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phospholipids Protein Kinases Signal Transduction
Autophagy impairment in Parkinson's disease.
Parkinson's disease (PD) is a debilitating movement disorder typically associated with the accumulation of intracytoplasmic aggregate prone protein deposits. Over recent years, increasing evidence has led to the suggestion that...
The Effect of Using Digital Stories in Teaching English as a Second Language
The purpose of this study is to analyze the effect of using digital storytelling on motivation and learning strategies in foreign language teaching. This study was conducted with 20 students enrolled in the preparatory class to...
Published by: IGI Global Scientific Publishing
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Lidia Wrobel, Farah H Siddiqi, Sandra M Hill, Sung Min Son, Cansu Karabiyik, Hyunjeong Kim, David C Rubinsztein
Jan 19, 2021
The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been linked to diverse human diseases, including cancer and...
RICTOR USP9X growth factor signaling mTORC2 Mechanistic Target of Rapamycin Complex 2 posttranslational modification ubiquitin-specific protease 9X Animals Cell Line Tumor Female Gene Expression Regulation Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Intercellular Signaling Peptides and Proteins Male Mechanistic Target of Rapamycin Complex 2 Mice Mice Inbred C57BL Protein Binding Protein Processing Post-Translational Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction Ubiquitin Thiolesterase Ubiquitination
Vinexin contributes to autophagic decline in brain ageing across species.
So Jung Park, Rebecca A Frake, Cansu Karabiyik, Sung Min Son, Farah H Siddiqi, Carla F Bento, Peter Sterk, Mariella Vicinanza, Mariana Pavel, David C Rubinsztein
May 10, 2022
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Lidia Wrobel, Sandra M Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W Bürli, David C Rubinsztein
Jul 16, 2022
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo JR Fernandes, Andrew Bassett, Eric Karran, Bruce L Miller, Angeleen Fleming, David C Rubinsztein
Mar 13, 2019
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins...
Animals Animals Genetically Modified Autophagy Cell Line Cerebral Cortex Disease Models Animal Drug Repositioning Embryo Mammalian Embryo Nonmammalian Felodipine Female Humans Induced Pluripotent Stem Cells Male Mice Mice Inbred C57BL Mutation Neurodegenerative Diseases Neurons Neuroprotective Agents Primary Cell Culture Swine Swine Miniature Treatment Outcome Zebrafish ALPHA-SYNUCLEIN
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Lidia Wrobel, Sandra M Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W Bürli, David C Rubinsztein
Aug 16, 2022
Multimodal Integration and Vividness in the Angular Gyrus During Episodic Encoding and Retrieval.
Much evidence suggests that the angular gyrus (AnG) is involved in episodic memory, but its precise role has yet to be determined. We examined two possible accounts within the same experimental paradigm: the "cortical binding of...
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia
Qiao Fan, Xiaobo Guo, J Willem L Tideman, Katie M Williams, Seyhan Yazar, S Mohsen Hosseini, Laura D Howe, Beaté St Pourcain, David M Evans, Nicholas J Timpson, George McMahon, Pirro G Hysi, Eva Krapohl, Ya Xing Wang, Jost B Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L Young, Olavi Pärssinen, Konrad Oexle, Norbert Pfeiffer, Joan E Bailey-Wilson, Andrew D Paterson, Caroline CW Klaver, Robert Plomin, Christopher J Hammond, David A Mackey, Mingguang He, Seang-Mei Saw, Cathy Williams, Jeremy A Guggenheim, CREAM Consortium
Aug 03, 2018
Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here...
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
David L Duffy, Gu Zhu, Xin Li, Marianna Sanna, Mark M Iles, Leonie C Jacobs, David M Evans, Seyhan Yazar, Jonathan Beesley, Matthew H Law, Peter Kraft, Alessia Visconti, John C Taylor, Fan Lui, Margaret J Wright, Anjali K Henders, Lisa Bowdler, Dan Glass, Arfan M Ikram, André G Uitterlinden, Pamela A Madden, Andrew C Heath, Elliot C Nelson, Adele C Green, Stephen Chanock, Jennifer H Barrett, Matthew A Brown, Nicholas K Hayward, Stuart MacGregor, Richard A Sturm, Alex W Hewitt, Melanoma GWAS Consortium, Manfred Kayser, David J Hunter, Julia A Newton Bishop, Timothy D Spector, Grant W Montgomery, David A Mackey, George Davey Smith, Tamar E Nijsten, D Timothy Bishop, Veronique Bataille, Mario Falchi, Jiali Han, Nicholas G Martin
Jan 31, 2019
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We...
Carrier Proteins Cytochrome P-450 CYP1B1 Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Group VI Phospholipases A2 Guanine Nucleotide Exchange Factors Histone Deacetylases Humans Interferon Regulatory Factors Melanoma MicroRNAs Microfilament Proteins Nerve Tissue Proteins Nevus Pigmented Nuclear Proteins Polymorphism Single Nucleotide RNA RNA-Binding Proteins Receptors G-Protein-Coupled Repressor Proteins Skin Neoplasms Stem Cell Factor Telomerase Telomere-Binding Proteins White People
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
Qiao Fan, Alfred Pozarickij, Nicholas YQ Tan, Xiaobo Guo, Virginie JM Verhoeven, Veronique Vitart, Jeremy A Guggenheim, Masahiro Miyake, J Willem L Tideman, Anthony P Khawaja, Liang Zhang, Stuart MacGregor, René Höhn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S Tedja, Jing Xie, Carla Lanca, Ya Xing Wang, Srujana Sahebjada, Johanna Mazur, Alireza Mirshahi, Nicholas G Martin, Seyhan Yazar, Craig E Pennell, Maurice Yap, Annechien EG Haarman, Clair A Enthoven, JanRoelof Polling, Consortium for Refractive Error and Myopia (CREAM), UK Biobank Eye and Vision Consortium, Alex W Hewitt, Vincent WV Jaddoe, Cornelia M van Duijn, Caroline Hayward, Ozren Polasek, E-Shyong Tai, Hosoda Yoshikatsu, Pirro G Hysi, Terri L Young, Akitaka Tsujikawa, Jie Jing Wang, Paul Mitchell, Norbert Pfeiffer, Olavi Pärssinen, Paul J Foster, Maurizio Fossarello, Shea Ping Yip, Cathy Williams, Christopher J Hammond, Jost B Jonas, Mingguang He, David A Mackey, Tien-Yin Wong, Caroline CW Klaver, Seang-Mei Saw, Paul N Baird, Ching-Yu Cheng
Mar 19, 2021
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in...
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error
Qiao Fan, Alfred Pozarickij, Nicholas Y. Q. Tan, Xiaobo Guo, Virginie J. M. Verhoeven, Veronique Vitart, Jeremy A. Guggenheim, Masahiro Miyake, J. Willem L. Tideman, Anthony P. Khawaja, Liang Zhang, Stuart MacGregor, René Höhn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S. Tedja, Jing Xie, Carla Lanca, Ya Xing Wang, Srujana Sahebjada, Johanna Mazur, Alireza Mirshahi, Nicholas G. Martin, Seyhan Yazar, Craig E. Pennell, Maurice Yap, Annechien E. G. Haarman, Clair A. Enthoven, JanRoelof Polling, Alex W. Hewitt, Vincent W. V. Jaddoe, Cornelia M. van Duijn, Caroline Hayward, Ozren Polasek, E-Shyong Tai, Hosoda Yoshikatsu, Pirro G. Hysi, Terri L. Young, Akitaka Tsujikawa, Jie Jing Wang, Paul Mitchell, Norbert Pfeiffer, Olavi Pärssinen, Paul J. Foster, Maurizio Fossarello, Shea Ping Yip, Cathy Williams, Christopher J. Hammond, Jost B. Jonas, Mingguang He, David A. Mackey, Tien-Yin Wong, Caroline C. W. Klaver, Seang-Mei Saw, Paul N. Baird, Ching-Yu Cheng, Joan E. Bailey-Wilson, Amutha Barathi Veluchamy, Kathryn P. Burdon, Harry Campbell, Li Jia Chen, Emily Y. Chew, Jamie E. Craig, Phillippa M. Cumberland, Margaret M. Deangelis, Cécile Delcourt, Xiaohu Ding, David M. Evans, Puya Gharahkhani, Adriana I. Iglesias, Toomas Haller, Xikun Han, Quan Hoang, Robert P., Jr. Igo, Sudha K. Iyengar, Mika Kähönen, Jaakko Kaprio, Barbara E. Klein, Ronald Klein, Jonathan H. Lass, Kris Lee, Terho Lehtimäki, Deyana D. Lewis, Qing Li, Shi-Ming Li, Leo-Pekka Lyytikäinen, Akira Meguro, Andres Metspalu, Candace D. Middlebrooks, Nobuhisa Mizuki, Anthony M. Musolf, Stefan Nickels, Konrad Oexle, Chi Pui Pang, Andrew D. Paterson, Jugnoo S. Rahi, Olli Raitakari, Igor Rudan, Dwight Stambolian, Claire L. Simpson, Ningli Wang, Wen Bin Wei, Katie M. Williams, James F. Wilson, Robert Wojciechowski, Kenji Yamashiro, Jason C. S. Yam, Xiangtian Zhou, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Y. L. Chua, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Marcus Fruttiger, John E. J. Gallacher, David F. Garway-Heath, Jane Gibson, Dan Gore, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pearse A. Keane, Sir Peng T. Khaw, Gerassimos Lascaratos, Andrew J. Lotery, Tom Macgillivray, Sarah Mackie, Keith Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. McKay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah A. Muthy, Eoin O’Sullivan, Chris G. Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Stephen A. Vernon, Ananth C. Viswanathan, Katie Williams, Jayne V. Woodside, Max M. Yates, Jennifer Yip, Yalin Zheng
Feb 17, 2021
Abstract: Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature...