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Results: 391
Elaine Fuchs, 1998
The Rockefeller University
Jan 01, 0001
Elaine Fuchs. Beauty is skin deep: the fascinating biology of the epidermis and its appendages
Posted with permission
Published by: Wiley-Liss, Inc.
ELAINE FUCHS
The Rockefeller University
Jan 01, 0001
Congratulations to Professor Elaine Fuchs, recipient of the National Medal of Science: "For her pioneering use of cell biology and molecular genetics in mice to understand the basis of inherited diseases in humans and her...
Published by: The Rockefeller University
Conditions for the spread of CRISPR-Cas immune systems into bacterial populations
Josie F.K. Elliott, David V. McLeod, Tiffany B. Taylor, Edze R. Westra, Sylvain Gandon, Bridget N.J. Watson
Jun 19, 2024
Bacteria contain a wide variety of innate and adaptive immune systems which provide protection to the host against invading genetic material, including bacteriophages (phages). It is becoming increasingly clear that bacterial...
bacteria–phage interactions CRISPR-Cas Ecology evolutionary epidemiology horizontal gene transfer mathematical theory microbial ecology and evolution Resistance evolution /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics
Single Source Precursors for Calcium Sulfide (CaS) Deposition
Here we describe preliminary studies into the synthesis structural characterisation and thermal properties of a family of calcium xanthate precursors for application in the deposition of CaS thin films. The straightforward...
Primary, secondary and tertiary effects of carbohydrate ingestion during exercise
The purpose of this Current Opinion paper is to describe the journey of ingested carbohydrate from ‘mouth to mitochondria’ culminating in energy production in skeletal muscles during exercise. This journey is conveniently...
Hodge Numbers from Picard-Fuchs Equations
Given a variation of Hodge structure over $\mathbb{P}^1$ with Hodge numbers
$(1,1,\dots,1)$, we show how to compute the degrees of the Deligne extension of
its Hodge bundles, following Eskin-Kontsevich-M\"oller-Zorich, by using...
Glucose Plus Fructose Ingestion for Post‐Exercise Recovery—Greater than the Sum of Its Parts?
Carbohydrate availability in the form of muscle and liver glycogen is an important determinant of performance during prolonged bouts of moderate- to high-intensity exercise. Therefore, when effective endurance performance is an...
Conditions for the spread of CRISPR-Cas immune systems into bacterial populations
Josie F.K. Elliott, David V. McLeod, Tiffany B. Taylor, Edze R. Westra, Sylvain Gandon, Bridget N.J. Watson
Jun 19, 2024
Bacteria contain a wide variety of innate and adaptive immune systems which provide protection to the host against invading genetic material, including bacteriophages (phages). It is becoming increasingly clear that bacterial...
bacteria–phage interactions CRISPR-Cas Ecology evolutionary epidemiology horizontal gene transfer mathematical theory microbial ecology and evolution Resistance evolution /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics
Primary, secondary and tertiary effects of carbohydrate ingestion during exercise
The purpose of this Current Opinion paper is to describe the journey of ingested carbohydrate from ‘mouth to mitochondria’ culminating in energy production in skeletal muscles during exercise. This journey is conveniently...
Single Source Precursors for Calcium Sulfide (CaS) Deposition
Here we describe preliminary studies into the synthesis structural characterisation and thermal properties of a family of calcium xanthate precursors for application in the deposition of CaS thin films. The straightforward...
Type I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity.
Bridget N J Watson, Reuben B Vercoe, George P C Salmond, Edze R Westra, Raymond H J Staals, Peter C Fineran
Jan 06, 2020
Type I CRISPR-Cas systems are abundant and widespread adaptive immune systems in bacteria and can greatly enhance bacterial survival in the face of phage infection. Upon phage infection, some CRISPR-Cas immune responses result...
Liver glycogen metabolism during and after prolonged endurance-type exercise
Carbohydrate and fat are the main substrates utilized during prolonged endurance-type exercise. The relative contribution of each is primarily determined by the intensity and duration of exercise, along with individual training...
Investigating Genetic (IN)Compatibility Between Temperate Phages and CRISPR-CAS Systems in Staphylococcus Aureus
Gregory W Goldberg
Jan 01, 0001
Prokaryotic organisms employ various mechanisms for defending against parasitism by viruses and other mobile genetic elements. One form of defense comprises the adaptive immune systems derived from clustered, regularly...
Published by: Rockefeller University
Glucose Plus Fructose Ingestion for Post‐Exercise Recovery—Greater than the Sum of Its Parts?
Carbohydrate availability in the form of muscle and liver glycogen is an important determinant of performance during prolonged bouts of moderate- to high-intensity exercise. Therefore, when effective endurance performance is an...
CPISPR-CAS: From a Prokaryotic Immune System to a Gene Editing Tool
Wenyan Jiang
Jan 01, 0001
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and their associated genes (cas) encode an adaptive, small-RNA-based immune system that protects prokaryotes from infectious phages and plasmids. CRISPR-Cas...
Published by: Rockefeller University
Liver glycogen metabolism during and after prolonged endurance-type exercise
Carbohydrate and fat are the main substrates utilized during prolonged endurance-type exercise. The relative contribution of each is primarily determined by the intensity and duration of exercise, along with individual training...
Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
Pascal Maguin
Jan 01, 0001
Bacteria have evolved numerous mechanisms to resist the constant assault of viruses (called bacteriophages, or simply phages) that can infect and kill them. Restriction-modification (RM) systems represent one such strategy....
Published by: Rockefeller University
Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response
Philip M Nussenzweig
Jan 01, 0001
Prokaryotes have developed numerous defense strategies to combat the constant threat of viruses (bacteriophages) that endanger them. Clustered, regularly interspaced short palindromic repeats (CRISPR) loci provide archaea and...
Published by: Rockefeller University
Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists
Javier T. Gonzalez, Cas J. Fuchs, Fiona E. Smith, Pete E. Thelwall, Roy Taylor, Emma J. Stevenson, Michael I. Trenell, Naomi M. Cermak, Luc J. C. van Loon
Dec 15, 2015
Purpose: To define the effect of glucose ingestion compared to sucrose ingestion on liver and muscle glycogen depletion during prolonged endurance-type exercise. Methods: Fourteen cyclists completed two 3-h bouts of cycling at...
Functional Organization of Molecular Memories in the CRISPR-Cas Immune System
Jon McGinn
Jan 01, 0001
CRISPR-Cas systems endow bacteria and archaea with adaptive immunity against foreign genetic threats, like phages and plasmids. These immune systems are comprised of CRISPR-associated (Cas) protein effectors and DNA-based...
Published by: Rockefeller University
Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes
Cas Fuchs, Javier Gonzalez, M Beelen, Naomi Cermak, Fiona Smith, Pete Thelwall, Roy Taylor, Michael Trenell, E Stevenson, L J C van Loon
Jun 01, 2016
Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with...
A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules.
Maurizio Labbate, Fabini D Orata, Nicola K Petty, Nathasha D Jayatilleke, William L King, Paul C Kirchberger, Chris Allen, Gulay Mann, Ankur Mutreja, Nicholas R Thomson, Yan Boucher, Ian G Charles
Feb 07, 2019
Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139 Vibrio cholerae. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139 V. cholerae. Perhaps...
Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes
Cas Fuchs, Javier Gonzalez, M Beelen, Naomi Cermak, Fiona Smith, Pete Thelwall, Roy Taylor, Michael Trenell, E Stevenson, L J C van Loon
Jun 01, 2016
Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with...
Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence
Claire T Kenney
Jan 01, 0001
Viruses that infect prokaryotes, called bacteriophages or phages, are thought to outnumber bacteria by a ratio of 10:1 and provide a constant threat to their hosts. In response, bacteria have evolved numerous defense mechanisms...
Published by: Rockefeller University
Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
Jakob Træland Rostøl
Jan 01, 0001
To protect against parasites like bacteriophages and plasmids, bacteria employ diverse and sophisticated defence systems. Clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas systems are adaptive immune...
Published by: Rockefeller University
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