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Results: 134
Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease.
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H Chung, Kowsar A Isse, Jasmine L Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G Rozen, Matthew Hoare, Peter Campbell, J William O Ballard, Nigel Turner, Margaret J Morris, Shilpa Chokshi, Neil A Youngson
Jun 29, 2022
Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease.
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H Chung, Kowsar A Isse, Jasmine L Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G Rozen, Matthew Hoare, Peter Campbell, J William O Ballard, Nigel Turner, Margaret J Morris, Shilpa Chokshi, Neil A Youngson
Jul 24, 2022
BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well...
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Digital Participatory Platforms for Urban Regeneration
Despite the increase in the globally connected population, there is still a high percentage of European citizens who do not have basic digital skills. In the era of smart cities, the Digital Divide affects the possibility for...
Published by: IGI Global Scientific Publishing
A framework for parameter estimation and model selection from experimental data in systems biology using approximate Bayesian computation.
As modeling becomes a more widespread practice in the life sciences and biomedical sciences, researchers need reliable tools to calibrate models against ever more complex and detailed data. Here we present an approximate...
Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling.
Sarah Filippi, Chris P Barnes, Paul DW Kirk, Takamasa Kudo, Katsuyuki Kunida, Siobhan S McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael PH Stumpf
Jul 16, 2018
Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically identical cells. This affects how individual cells respond differentially to the same environmental stimulus. However, the origins of...
Nuclear mechanotransduction in stem cells.
In development and in homeostatic maintenance of tissues, stem cells and progenitor cells are constantly subjected to forces. These forces can lead to significant changes in gene expression and function of stem cells, mediating...
Primordial Helium-3 Redux
Abstract
We report the first direct measurement of the helium isotope ratio, 3 He/4 He, outside of the Local Interstellar Cloud, as part of...
Ryan J Cooke, Pasquier Noterdaeme, James W Johnson, Max Pettini, Louise Welsh, Celine Peroux, Michael T Murphy, David H Weinberg
Jun 15, 2022
Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma.
Christopher Welberry, Isabel Macdonald, Jane McElveen, Celine Parsy-Kowalska, Jared Allen, Graham Healey, William Irving, Andrea Murray, Caroline Chapman
May 06, 2020
BACKGROUND: Hepatocellular carcinoma (HCC) continues to be a leading challenge in modern oncology. Early detection via blood-based screening tests has the potential to cause a stage-shift at diagnosis and improve clinical...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Ben Davies
Oct 08, 2021
High fragmentation characterizes tumour-derived circulating DNA.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry
May 01, 2019
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations. Certainly due to lack of normalization...
Practical guidelines for the comprehensive analysis of ChIP-seq data.
Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang
Jun 19, 2020
Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the...
Community Hospitals in Selected High Income Countries
Eleanor M Winpenny, Jennie Corbett, Celine Miani, Sarah King, Emma Pitchforth, Tom Ling, Edwin van Teijlingen, Ellen Nolte
Dec 16, 2016
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Dec 06, 2019
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy.
Dorothea Pinotsi, Alexander K Buell, Celine Galvagnion, Christopher M Dobson, Gabriele S Kaminski Schierle, Clemens F Kaminski
Feb 12, 2020
The self-assembly of normally soluble proteins into fibrillar amyloid structures is associated with a range of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. In the present study, we show that...
Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.
Gaetano Corazzelli, Ferdinando Frigeri, Manuela Arcamone, Luigi Aloj, Gaetana Capobianco, Cristina Becchimanzi, Emanuela Morelli, Francesco Volzone, Gianpaolo Marcacci, Filippo Russo, Rosaria De Filippi, Secondo Lastoria, Antonio Pinto
Dec 21, 2018
Patients with recurring T-cell non-Hodgkin lymphoma (T-NHL) are incurable and candidate for investigational agents. Here, we report on five patients with T-NHL refractory to multiple chemotherapy lines, including in all cases...
BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report.
Andrew P Sage, Dimitrios Tsiantoulas, Lauren Baker, James Harrison, Leanne Masters, Deirdre Murphy, Celine Loinard, Christoph J Binder, Ziad Mallat
Sep 23, 2016
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Benjamin M Davies
Jan 06, 2022
Research activity amongst DCM research priorities.
Ben Grodzinski, Harry Bestwick, Faheem Bhatti, Rory Durham, Maaz Khan, Celine Iswarya Partha Sarathi, Jye Quan Teh, Oliver Mowforth, Benjamin Davies
May 12, 2021
INTRODUCTION: Degenerative cervical myelopathy (DCM) is a progressive neurodegenerative disorder. DCM is common (estimated prevalence, 2% of adults) and significantly impacts quality of life. The AO Spine RECODE-DCM (Research...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Benjamin M Davies
Oct 31, 2021
Introduction:: Degenerative cervical myelopathy (DCM) is the commonest cause of adult spinal cord impairment worldwide, encompassing chronic compression of the spinal cord, neurological disability and diminished quality of life....
Butene Emissions From Coastal Ecosystems May Contribute to New Particle Formation
C Giorio, JF Doussin, B D’Anna, S Mas, D Filippi, C Denjean, MD Mallet, T Bourrianne, F Burnet, M Cazaunau, C Chikwililwa, K Desboeufs, A Feron, V Michoud, A Namwoonde, MO Andreae, SJ Piketh, P Formenti
May 20, 2022
Marine ecosystems are important drivers of the global climate system. They emit volatile species into the atmosphere, involved in complex reaction cycles that influence the lifetime of greenhouse gases. Sea spray and marine...
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
Andy Evans, Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah
Oct 10, 2018
INTRODUCTION: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear...
Breast Cancer neoadjuvant chemotherapy Prognosis Shear wave elastography ULTRASOUND Adult Aged Aged 80 and over Biomarkers Breast Neoplasms Elasticity Elasticity Imaging Techniques Female Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Preoperative Period Prognosis Tumor Microenvironment
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