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Results: 378
Practical guidelines for the comprehensive analysis of ChIP-seq data.
Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang
Jun 19, 2020
Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the...
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Nuclear mechanotransduction in stem cells.
In development and in homeostatic maintenance of tissues, stem cells and progenitor cells are constantly subjected to forces. These forces can lead to significant changes in gene expression and function of stem cells, mediating...
Primordial Helium-3 Redux
Abstract
We report the first direct measurement of the helium isotope ratio, 3 He/4 He, outside of the Local Interstellar Cloud, as part of...
Ryan J Cooke, Pasquier Noterdaeme, James W Johnson, Max Pettini, Louise Welsh, Celine Peroux, Michael T Murphy, David H Weinberg
Jun 15, 2022
Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma.
Christopher Welberry, Isabel Macdonald, Jane McElveen, Celine Parsy-Kowalska, Jared Allen, Graham Healey, William Irving, Andrea Murray, Caroline Chapman
May 06, 2020
BACKGROUND: Hepatocellular carcinoma (HCC) continues to be a leading challenge in modern oncology. Early detection via blood-based screening tests has the potential to cause a stage-shift at diagnosis and improve clinical...
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate...
carboxymethylcellulose sod nium Gene Expression Cytokines interferon Signal Transduction virus vaccine
Published by: Rockefeller University
High fragmentation characterizes tumour-derived circulating DNA.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry
May 01, 2019
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations. Certainly due to lack of normalization...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Dec 06, 2019
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.
Beckwith–Wiedemann syndrome fetal growth restriction mouse model Placentomegaly Animals Basic Helix-Loop-Helix Transcription Factors Beckwith-Wiedemann syndrome Biomarkers Cell Lineage Disease Models Animal Embryo Loss Female Fetal Growth Retardation Fetus Gene Expression Regulation Developmental Glycogen Mice Models Genetic Placenta Pregnancy Trophoblasts
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy.
Dorothea Pinotsi, Alexander K Buell, Celine Galvagnion, Christopher M Dobson, Gabriele S Kaminski Schierle, Clemens F Kaminski
Feb 12, 2020
The self-assembly of normally soluble proteins into fibrillar amyloid structures is associated with a range of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. In the present study, we show that...
Research activity amongst DCM research priorities.
Ben Grodzinski, Harry Bestwick, Faheem Bhatti, Rory Durham, Maaz Khan, Celine Iswarya Partha Sarathi, Jye Quan Teh, Oliver Mowforth, Benjamin Davies
May 12, 2021
INTRODUCTION: Degenerative cervical myelopathy (DCM) is a progressive neurodegenerative disorder. DCM is common (estimated prevalence, 2% of adults) and significantly impacts quality of life. The AO Spine RECODE-DCM (Research...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Benjamin M Davies
Oct 31, 2021
Introduction:: Degenerative cervical myelopathy (DCM) is the commonest cause of adult spinal cord impairment worldwide, encompassing chronic compression of the spinal cord, neurological disability and diminished quality of life....
Making space for art
The physical and material aspects of space, such as geographical distance or boundaries, have social and symbolic consequences that impact how people influence and are influenced by institutions. Social actors can however...
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
Andy Evans, Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah
Oct 10, 2018
INTRODUCTION: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear...
Breast Cancer neoadjuvant chemotherapy Prognosis Shear wave elastography ULTRASOUND Adult Aged Aged 80 and over Biomarkers Breast Neoplasms Elasticity Elasticity Imaging Techniques Female Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Preoperative Period Prognosis Tumor Microenvironment
A Compendium of Mutational Signatures of Environmental Agents.
Jill E Kucab, Xueqing Zou, Sandro Morganella, Madeleine Joel, A Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P Jackson, Volker M Arlt, David H Phillips, Serena Nik-Zainal
Mar 04, 2019
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Nov 03, 2020
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Adenosine Triphosphate Binding Sites Casein Kinase II Catalytic Domain Cell Line Tumor Cell Movement Cell Proliferation Crystallography X-Ray Holoenzymes Humans Kinetics Molecular Docking Simulation Peptides Phosphorylation Protein Kinase Inhibitors Protein Subunits Substrate Specificity Surface Plasmon Resonance
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Rosie Bell, Rebecca J Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K Xu, Sandeep Satapathy, Celine Galvagnion, Mark R Wilson, Christopher M Dobson, Janet R Kumita, Michele Vendruscolo
Sep 12, 2022
Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since...
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