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Results: 231
Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma.
Christopher Welberry, Isabel Macdonald, Jane McElveen, Celine Parsy-Kowalska, Jared Allen, Graham Healey, William Irving, Andrea Murray, Caroline Chapman
May 06, 2020
BACKGROUND: Hepatocellular carcinoma (HCC) continues to be a leading challenge in modern oncology. Early detection via blood-based screening tests has the potential to cause a stage-shift at diagnosis and improve clinical...
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion
clinical research/practice kidney transplantation/nephrology organ acceptance organ perfusion and preservation Adult Aged Female Graft Rejection Humans Kidney Function Tests Kidney Transplantation Liver Male Organ Preservation Outcome Assessment Health Care Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement
Bioengineering solutions for ureteric disorders
Konstantinos Kapetanos, Alexander Light, Niyukta Thakare, Krishnaa Mahbubani, Kasra Saeb-Parsy, Kourosh Saeb-Parsy
May 15, 2022
OBJECTIVES: To summarise the causes of ureteric damage and the current standard of care, discussing the risks and benefits of available therapeutic options. We then focus on the current and future solutions that can be provided...
Advances in the generation of bioengineered bile ducts.
Alexander W Justin, Kourosh Saeb-Parsy, Athina E Markaki, Ludovic Vallier, Fotios Sampaziotis
Jan 30, 2018
Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation.
TRANSPLANT SURGERY Adolescent Adult Aged Cold Temperature Cryopreservation Delayed Graft Function Fibrosis Graft Rejection Humans Immunosuppressive Agents Kidney Kidney Transplantation Length of Stay Middle Aged Organ Preservation Organ Preservation Solutions Perfusion Renal Dialysis Treatment Outcome Young Adult
Nuclear mechanotransduction in stem cells.
In development and in homeostatic maintenance of tissues, stem cells and progenitor cells are constantly subjected to forces. These forces can lead to significant changes in gene expression and function of stem cells, mediating...
The Role of Ischemia/Reperfusion Injury in Early Hepatic Allograft Dysfunction.
Liver transplantation (LT) is the only available curative treatment for patients with end-stage liver disease. Early allograft dysfunction (EAD) is a life-threatening complication of LT and is thought to be mediated in large...
Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies.
Bethany Bareham, Nikitas Georgakopoulos, Alba Matas-Céspedes, Michelle Curran, Kourosh Saeb-Parsy
Sep 08, 2021
Despite the significant contributions of immunocompetent mouse models to the development and assessment of cancer immunotherapies, they inadequately represent the genetic and biological complexity of corresponding human cancers....
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and...
Primordial Helium-3 Redux
Abstract
We report the first direct measurement of the helium isotope ratio, 3 He/4 He, outside of the Local Interstellar Cloud, as part of...
Ryan J Cooke, Pasquier Noterdaeme, James W Johnson, Max Pettini, Louise Welsh, Celine Peroux, Michael T Murphy, David H Weinberg
Jun 15, 2022
Mitochondria as Therapeutic Targets in Transplantation.
Kourosh Saeb-Parsy, Jack L Martin, Dominic M Summers, Christopher JE Watson, Thomas Krieg, Michael P Murphy
Sep 28, 2020
Advances in surgical procedures, technology, and immune suppression have transformed organ transplantation. However, the metabolic changes that occur during organ retrieval, storage, and implantation have been relatively...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Ben Davies
Oct 08, 2021
Pancreatic allograft thrombosis
A Hakeem, J Chen, S Iype, MR Clatworthy, CJE Watson, EM Godfrey, S Upponi, K Saeb-Parsy
Nov 30, 2017
Pancreatic allograft thrombosis (PAT) remains the leading cause of nonimmunologic graft failure. Here, we propose a new computed tomography (CT) grading system of PAT to identify risk factors for allograft loss and outline a...
clinical research/practice coagulation and hemostasis complication Graft Survival health services and outcomes research pancreas/simultaneous pancreas-kidney transplantation thrombosis and thromboembolism Adolescent Adult Algorithms Allografts Child Female Follow-Up Studies Graft Rejection Graft Survival Humans Male Middle Aged Pancreas Transplantation Postoperative Complications Prognosis Retrospective Studies Risk Factors Thrombosis Tomography X-Ray Computed Young Adult
Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes.
Laurence SC Lok, Thomas W Dennison, Krishnaa M Mahbubani, Kourosh Saeb-Parsy, Edwin R Chilvers, Menna R Clatworthy
Sep 05, 2019
High fragmentation characterizes tumour-derived circulating DNA.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry
May 01, 2019
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations. Certainly due to lack of normalization...
Community Hospitals in Selected High Income Countries
Eleanor M Winpenny, Jennie Corbett, Celine Miani, Sarah King, Emma Pitchforth, Tom Ling, Edwin van Teijlingen, Ellen Nolte
Dec 16, 2016
Practical guidelines for the comprehensive analysis of ChIP-seq data.
Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang
Jun 19, 2020
Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the...
B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.
Akimichi Inaba, Zewen K Tuong, Alexandra M Riding, Rebeccah J Mathews, Jack L Martin, Kourosh Saeb-Parsy, Menna R Clatworthy
Jul 22, 2020
Immunological considerations and challenges for regenerative cellular therapies.
Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Jun 16, 2021
The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that integrate and function optimally. The capacity of pluripotent stem cells to produce unlimited numbers of differentiated cells is...
Ureteric complications in recipients of kidneys from donation after circulatory death donors.
Trina-Jo Mah, Dermot H Mallon, Oliver Brewster, Kourosh Saeb-Parsy, Andrew J Butler, J Andrew Bradley, Vasilis Kosmoliaptsis
Mar 29, 2017
DCD kidney transplantation ureteric complications Adolescent Adult Aged Aged 80 and over Brain Death Child Child Preschool Constriction Pathologic Female Follow-Up Studies Glomerular Filtration Rate Humans Incidence Kidney Function Tests Kidney Transplantation Male Middle Aged Postoperative Complications Prognosis Retrospective Studies Risk Factors Tissue Donors Tissue and Organ Procurement United Kingdom Ureter Urologic Diseases Young Adult
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