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Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
Andy Evans, Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah
Oct 10, 2018
INTRODUCTION: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear...
Breast Cancer neoadjuvant chemotherapy Prognosis Shear wave elastography ULTRASOUND Adult Aged Aged 80 and over Biomarkers Breast Neoplasms Elasticity Elasticity Imaging Techniques Female Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Preoperative Period Prognosis Tumor Microenvironment
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Nuclear mechanotransduction in stem cells.
In development and in homeostatic maintenance of tissues, stem cells and progenitor cells are constantly subjected to forces. These forces can lead to significant changes in gene expression and function of stem cells, mediating...
Primordial Helium-3 Redux
Abstract
We report the first direct measurement of the helium isotope ratio, 3 He/4 He, outside of the Local Interstellar Cloud, as part of...
Ryan J Cooke, Pasquier Noterdaeme, James W Johnson, Max Pettini, Louise Welsh, Celine Peroux, Michael T Murphy, David H Weinberg
Jun 15, 2022
Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma.
Christopher Welberry, Isabel Macdonald, Jane McElveen, Celine Parsy-Kowalska, Jared Allen, Graham Healey, William Irving, Andrea Murray, Caroline Chapman
May 06, 2020
BACKGROUND: Hepatocellular carcinoma (HCC) continues to be a leading challenge in modern oncology. Early detection via blood-based screening tests has the potential to cause a stage-shift at diagnosis and improve clinical...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Ben Davies
Oct 08, 2021
High fragmentation characterizes tumour-derived circulating DNA.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry
May 01, 2019
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations. Certainly due to lack of normalization...
Practical guidelines for the comprehensive analysis of ChIP-seq data.
Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang
Jun 19, 2020
Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the...
Community Hospitals in Selected High Income Countries
Eleanor M Winpenny, Jennie Corbett, Celine Miani, Sarah King, Emma Pitchforth, Tom Ling, Edwin van Teijlingen, Ellen Nolte
Dec 16, 2016
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Dec 06, 2019
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy.
Dorothea Pinotsi, Alexander K Buell, Celine Galvagnion, Christopher M Dobson, Gabriele S Kaminski Schierle, Clemens F Kaminski
Feb 12, 2020
The self-assembly of normally soluble proteins into fibrillar amyloid structures is associated with a range of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. In the present study, we show that...
BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report.
Andrew P Sage, Dimitrios Tsiantoulas, Lauren Baker, James Harrison, Leanne Masters, Deirdre Murphy, Celine Loinard, Christoph J Binder, Ziad Mallat
Sep 23, 2016
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Benjamin M Davies
Jan 06, 2022
Research activity amongst DCM research priorities.
Ben Grodzinski, Harry Bestwick, Faheem Bhatti, Rory Durham, Maaz Khan, Celine Iswarya Partha Sarathi, Jye Quan Teh, Oliver Mowforth, Benjamin Davies
May 12, 2021
INTRODUCTION: Degenerative cervical myelopathy (DCM) is a progressive neurodegenerative disorder. DCM is common (estimated prevalence, 2% of adults) and significantly impacts quality of life. The AO Spine RECODE-DCM (Research...
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Benjamin M Davies
Oct 31, 2021
Introduction:: Degenerative cervical myelopathy (DCM) is the commonest cause of adult spinal cord impairment worldwide, encompassing chronic compression of the spinal cord, neurological disability and diminished quality of life....
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
A Compendium of Mutational Signatures of Environmental Agents.
Jill E Kucab, Xueqing Zou, Sandro Morganella, Madeleine Joel, A Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P Jackson, Volker M Arlt, David H Phillips, Serena Nik-Zainal
Mar 04, 2019
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Nov 03, 2020
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Adenosine Triphosphate Binding Sites Casein Kinase II Catalytic Domain Cell Line Tumor Cell Movement Cell Proliferation Crystallography X-Ray Holoenzymes Humans Kinetics Molecular Docking Simulation Peptides Phosphorylation Protein Kinase Inhibitors Protein Subunits Substrate Specificity Surface Plasmon Resonance
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Rosie Bell, Rebecca J Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K Xu, Sandeep Satapathy, Celine Galvagnion, Mark R Wilson, Christopher M Dobson, Janet R Kumita, Michele Vendruscolo
Sep 12, 2022
Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since...
Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge.
Akhilesh Jha, Fangyue Chen, Sam Mann, Ravi Shah, Randa Abu-Youssef, Holly Pavey, Helen Lin-Jia-Qi, Josh Cara, Daniel Cunningham, Kate Fitzpatrick, Celine Goh, Renee Ma, Souradip Mookerjee, Vaitehi Nageshwaran, Timothy Old, Catherine Oxley, Louise Jordon, Mayurun Selvan, Anna Wood, Andrew Ying, Chen Zhang, Dariusz Wozniak, Iain Goodhart, Frances Early, Marie Fisk, Jonathan Fuld
Mar 13, 2022
BACKGROUND: Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking...
Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease.
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H Chung, Kowsar A Isse, Jasmine L Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G Rozen, Matthew Hoare, Peter Campbell, J William O Ballard, Nigel Turner, Margaret J Morris, Shilpa Chokshi, Neil A Youngson
Jul 24, 2022
BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well...
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
Anasuya Chattopadhyay, Cornelius J O'Connor, Fengzhi Zhang, Celine Galvagnion, Warren RJD Galloway, Yaw Sing Tan, Jamie E Stokes, Taufiq Rahman, Chandra Verma, David R Spring, Laura S Itzhaki
Mar 10, 2016
Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line Tumor Cell Survival DNA Damage Escherichia coli Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53
Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.
Amber N Hurson, Parichoy Pal Choudhury, Chi Gao, Anika Hüsing, Mikael Eriksson, Min Shi, Michael E Jones, D Gareth R Evans, Roger L Milne, Mia M Gaudet, Celine M Vachon, Daniel I Chasman, Douglas F Easton, Marjanka K Schmidt, Peter Kraft, Montserrat Garcia-Closas, Nilanjan Chatterjee, B-CAST Risk Modelling Group
Dec 15, 2020
BACKGROUND: Rigorous evaluation of the calibration and discrimination of breast-cancer risk-prediction models in prospective cohorts is critical for applications under clinical guidelines. We comprehensively evaluated an...
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