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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
A System Dynamics Approach to Evaluate Advanced Persistent Threat Vectors
Cyber-attacks targeting high-profile entities are focused, persistent, and employ common vectors with varying levels of sophistication to exploit social-technical vulnerabilities. Advanced persistent threats (APTs) deploy...
Published by: IGI Global Scientific Publishing
Multidrug resistant enteric fever in South Asia
Christopher M Parry, Isabela Ribeiro, Kamini Walia, Priscilla Rupali, Stephen Baker, Buddha Basnyat
Apr 10, 2019
Investments in newer diagnostics and antimicrobial treatments are critical to improve management of enteric fever in South Asia, say Christopher Parry and colleagues
A Crime Scene Reconstruction for Digital Forensic Analysis
The abundance of digital data within modern vehicles makes digital vehicle forensics (DVF) a promising subfield of digital forensics (DF), with significant potential for investigations. In this research, the authors apply DVF...
Published by: IGI Global Scientific Publishing
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.
Chiara Marchetti, Katherine G Zyner, Stephan A Ohnmacht, Mathew Robson, Shozeb M Haider, Jennifer P Morton, Giovanni Marsico, Tam Vo, Sarah Laughlin-Toth, Ahmed A Ahmed, Gloria Di Vita, Ingrida Pazitna, Mekala Gunaratnam, Rachael J Besser, Ana CG Andrade, Seckou Diocou, Jeremy A Pike, David Tannahill, R Barbara Pedley, TR Jeffry Evans, W David Wilson, Shankar Balasubramanian, Stephen Neidle
Mar 26, 2018
Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having...
Animals Antimetabolites Antineoplastic Antineoplastic Agents Carcinoma Pancreatic Ductal Cell Line Tumor Computational Biology Computer Simulation DNA Damage Deoxycytidine Down-Regulation Drug Design Drug Resistance Neoplasm G-Quadruplexes Gene Expression Regulation Neoplastic Humans Mice Mice Nude Pancreatic Neoplasms Xenograft Model Antitumor Assays Gemcitabine
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Activation mechanism of the class D fungal GPCR dimer Ste2.
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1-Ste2-Ste181. In...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Dec 12, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Activation mechanism of the class D fungal GPCR dimer Ste2.
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1-Ste2-Ste181. In...
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Nov 16, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access...
Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease
Sophia CL Whitwell, Christopher G Mathew, Cathryn M Lewis, Alastair Forbes, Sally Watts, Jeremy Sanderson, Gareth J Hollands, A Toby Prevost, David Armstrong, Ann Louise Kinmonth, Stephen Sutton, Theresa M Marteau
Jun 14, 2011
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.
Daniel R Whiten, Dezerae Cox, Mathew H Horrocks, Christopher G Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R Kumita, Heath Ecroyd, Christopher M Dobson, David Klenerman, Mark R Wilson
Oct 10, 2018
Limit theory of combinatorial optimization for random geometric graphs
In the random geometric graph G(n, rn), n vertices are placed randomly in Euclidean d-space and edges are added between any pair of vertices distant at most rn from each other. We establish strong laws...
Clique-covering number Dense limit Domination number Independence number Minimum-weight matching Random geometric graph Sphere packing Subadditivity thermodynamic limit Traveling salesman problem /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
The Integrity and Yield of Genomic DNA Isolated from Whole Blood Following Long-Term Storage at -30°C.
Wenlong Carl Chen, Robyn Kerr, Andrew May, Babongile Ndlovu, Anelisa Sobalisa, Sanelisiwe T Duze, Lavania Joseph, Christopher G Mathew, Chantal Babb de Villiers
Jun 25, 2018
Long-term storage of whole blood can affect the integrity of DNA if it is not done under optimal conditions. The aim of this study was to determine whether long-term storage (2-19 years) of whole blood samples at -30°C had a...
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