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Results: 20
A comparison of covariate adjustment approaches under model misspecification in individually randomized trials.
Mia S Tackney, Tim Morris, Ian White, Clemence Leyrat, Karla Diaz-Ordaz, Elizabeth Williamson
Jan 06, 2023
Adjustment for baseline covariates in randomized trials has been shown to lead to gains in power and can protect against chance imbalances in covariates. For continuous covariates, there is a risk that the the form of the...
A comparison of covariate adjustment approaches under model misspecification in individually randomized trials.
Mia S Tackney, Tim Morris, Ian White, Clemence Leyrat, Karla Diaz-Ordaz, Elizabeth Williamson
Feb 09, 2023
Adjustment for baseline covariates in randomized trials has been shown to lead to gains in power and can protect against chance imbalances in covariates. For continuous covariates, there is a risk that the the form of the...
Central Amino Acid Sensing in the Control of Feeding Behavior.
Dietary protein quantity and quality greatly impact metabolic health via evolutionary-conserved mechanisms that ensure avoidance of amino acid imbalanced food sources, promote hyperphagia when dietary protein density is low, and...
Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse.
The normal function of the mammalian reproductive axis is strongly influenced by physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded by the Kiss1 gene, are potent regulators of the mammalian...
Median eminence myelin continuously turns over in adult mice.
Sophie Buller, Sara Kohnke, Robert Hansford, Takahiro Shimizu, William D Richardson, Clemence Blouet
Mar 08, 2023
OBJECTIVE: Oligodendrocyte progenitor cell differentiation is regulated by nutritional signals in the adult median eminence (ME), but the consequences on local myelination are unknown. The aim of this study was to characterize...
Propensity scores using missingness pattern information
Helen A Blake, Clémence Leyrat, Kathryn E Mansfield, Shaun Seaman, Laurie A Tomlinson, James Carpenter, Elizabeth J Williamson
Feb 10, 2020
Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.
Amparo Romero-Picó, Marta G Novelle, Omar Al-Massadi, Daniel Beiroa, Marta Tojo, Violeta Heras, Francisco Ruiz-Pino, Ana Senra, Miguel López, Clemence Blouet, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Diéguez
Apr 24, 2022
Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. Of note, this weight gain tends to be around the abdomen, which is frequently associated...
Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.
Amparo Romero-Picó, Marta G Novelle, Omar Al-Massadi, Daniel Beiroa, Marta Tojo, Violeta Heras, Francisco Ruiz-Pino, Ana Senra, Miguel López, Clemence Blouet, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Diéguez
Jun 07, 2022
Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. Of note, this weight gain tends to be around the abdomen, which is frequently associated...
Stopping renin-angiotensin system blockers after acute kidney injury and risk of adverse outcomes
Patrick Bidulka, Edouard L Fu, Clémence Leyrat, Fotini Kalogirou, Katherine SL McAllister, Edward J Kingdon, Kathryn E Mansfield, Masao Iwagami, Liam Smeeth, Catherine M Clase, Krishnan Bhaskaran, Merel van Diepen, Juan-Jesus Carrero, Dorothea Nitsch, Laurie A Tomlinson
Jul 29, 2021
BACKGROUND: The safety of restarting angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) after acute kidney injury (AKI) is unclear. There is concern that previous users do not restart...
Acute Kidney Injury Angiotensin II receptor blocker (ARB) Angiotensin-converting enzyme inhibitor (ACEI) Heart Failure Acute Kidney Injury Adolescent Adult Aged Aged 80 and over Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Cohort Studies Female Humans Male Middle Aged Proportional Hazards Models Sweden United Kingdom Young Adult
Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy
Clemence Blouet, Emma Roth, Simon Benoit, Baptiste Quentin, Brian Lam, Sarah Will, Marcella Ma, Nick Heeley, Tamana Darwish, Yashaswi Shrestha, Fiona Gribble, Frank Reimann, Irina Pshenichnaya, Giles Yeo, David Baker, James Trevaskis
Nov 16, 2020
Combinatorial therapies are under intense investigation for the development of more efficient anti-obesity drugs, however little is known about how they act in brain to produce enhanced anorexia and weight loss. Objectives: The...
CCK Combinatorial therapy GLP-1 Hunger Nucleus of the solitary tract obesity satiety Animals Anti-Obesity Agents Appetite Regulation Brain Diet High-Fat Eating Feeding Behavior Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Male Mice Mice Inbred C57BL Neurons obesity Receptors Cholecystokinin Solitary Nucleus Weight Loss
Propensity score analysis with partially observed covariates
Clémence Leyrat, Shaun R Seaman, Ian R White, Ian Douglas, Liam Smeeth, Joseph Kim, Matthieu Resche-Rigon, James R Carpenter, Elizabeth J Williamson
Jun 13, 2018
Missing covariates Rubin’s rules chained equations inverse probability of treatment weighting missingness pattern Bias Data Interpretation Statistical Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Models Statistical Observational Studies as Topic Pneumonia Probability Propensity Score Treatment Outcome
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
A GLP-1
David C Hornigold, Emma Roth, Victor Howard, Sarah Will, Stephanie Oldham, Matthew P Coghlan, Clemence Blouet, James L Trevaskis
Oct 10, 2018
Combination approaches for the treatment of metabolic diseases such as obesity and diabetes are becoming increasingly relevant. Co-administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist with a cholecystokinin...
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
Alice E Adriaenssens, Emma K Biggs, Tamana Darwish, John Tadross, Tanmay Sukthankar, Milind Girish, Joseph Polex-Wolf, Brain Y Lam, Ilona Zvetkova, Warren Pan, Davide Chiarugi, Giles SH Yeo, Clemence Blouet, Fiona M Gribble, Frank Reimann
Jul 31, 2019
Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting...
Food intake Glucose-dependent insulinotropic polypeptide Glucose-dependent insulinotropic polypeptide receptor Hypothalamus Aged 80 and over Animals Eating Female Gastric Inhibitory Polypeptide Gene Knock-In Techniques Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Humans Hypothalamus Mice Mice Inbred C57BL Mice Transgenic Neurons obesity Receptors Gastrointestinal Hormone
Stopping renin-angiotensin system blockers after acute kidney injury and risk of adverse outcomes
Patrick Bidulka, Edouard L. Fu, Clémence Leyrat, Fotini Kalogirou, Katherine S. L. McAllister, Edward J. Kingdon, Kathryn E. Mansfield, Masao Iwagami, Liam Smeeth, Catherine M. Clase, Krishnan Bhaskaran, Merel van Diepen, Juan-Jesus Carrero, Dorothea Nitsch, Laurie A. Tomlinson
Jul 29, 2020
Abstract: Background: The safety of restarting angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) after acute kidney injury (AKI) is unclear. There is concern that previous users do not...
The Ursinus Weekly, November 4, 1935
E. Kermit Harbaugh
Jan 01, 0001
Lettermen dance committee named Diplomacy offers interesting career Seniors choose Clemence Dane's play, "A Bill of Divorcement", for production New type class ring chosen by sophomores Addresses of alumni desired by office ...
Ursinus College Collegeville Pennsylvania newspaper Hall Chemical Society debate team William F. Philip Philip B. Willauer tennis cross country Football Soccer cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Wenwen Cheng, Ian Gonzalez, Warren Pan, Anthony H Tsang, Jessica Adams, Ermelinda Ndoka, Desiree Gordian, Basma Khoury, Karen Roelofs, Simon S Evers, Andrew MacKinnon, Shuangcheng Wu, Henriette Frikke-Schmidt, Jonathan N Flak, James L Trevaskis, Christopher J Rhodes, So-Ichiro Fukada, Randy J Seeley, Darleen A Sandoval, David P Olson, Clemence Blouet, Martin G Myers
Jan 22, 2020
To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake...
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Sara Kohnke, Sophie Buller, Danae Nuzzaci, Katherine Ridley, Brian Lam, Helena Pivonkova, Marie A Bentsen, Kimberly M Alonge, Chao Zhao, John Tadross, Staffan Holmqvist, Takahiro Shimizu, Hannah Hathaway, Huiliang Li, Wendy Macklin, Michael W Schwartz, William D Richardson, Giles SH Yeo, Robin Jm Franklin, Ragnhildur T Karadottir, David H Rowitch, Clemence Blouet
May 11, 2021
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance...
Energy balance Glucose homeostasis Hypothalamus Median eminence Nutrition obesity oligodendrocyte Perineuronal nets plasticity Adult Animals Cell Differentiation Cell Lineage Cell Proliferation Humans Male Mechanistic Target of Rapamycin Complex 1 Median eminence Mice Inbred C57BL Nerve Net Nutritional Physiological Phenomena Oligodendroglia Single-Cell Analysis Transcriptome
Benefits of protected areas for nonbreeding waterbirds adjusting their distributions under climate warming.
Elie Gaget, Diego Pavón-Jordán, Alison Johnston, Aleksi Lehikoinen, Wesley M Hochachka, Brett K Sandercock, Alaaeldin Soultan, Hichem Azafzaf, Nadjiba Bendjedda, Taulant Bino, Luka Božič, Preben Clausen, Mohamed Dakki, Koen Devos, Cristi Domsa, Vitor Encarnação, Kiraz Erciyas-Yavuz, Sándor Faragó, Teresa Frost, Clemence Gaudard, Lívia Gosztonyi, Fredrik Haas, Menno Hornman, Tom Langendoen, Christina Ieronymidou, Vasiliy A Kostyushin, Lesley J Lewis, Svein-Håkon Lorentsen, Leho Luigujõe, Włodzimierz Meissner, Tibor Mikuska, Blas Molina, Zuzana Musilová, Viktor Natykanets, Jean-Yves Paquet, Nicky Petkov, Danae Portolou, Jozef Ridzoň, Samir Sayoud, Marko Šćiban, Laimonas Sniauksta, Antra Stīpniece, Nicolas Strebel, Norbert Teufelbauer, Goran Topić, Danka Uzunova, Andrej Vizi, Johannes Wahl, Marco Zenatello, Jon E Brommer
May 27, 2021
Climate warming is driving changes in species distributions and community composition. Many species have a so-called climatic debt, that is, shifts in range lag behind shifts in temperature isoclines. Inside protected areas...
ajuste comunitario cambio de distribución colonización colonization community adjustment community temperature index extinción Extinction humedales range shift wetlands índice de temperatura comunitaria 定殖 湿地 灭绝 群落温度指数 群落调整 范围变化 Animals Biodiversity Birds climate change Conservation of Natural Resources Ecosystem Temperature