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Results: 89
Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa.
João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Vincent Plagnol, James Curtis, Marta Martins, Dinakantha Kumararatne, Ana Isabel Cordeiro, Conceição Neves, Luis Miguel Borrego, Matilda Katan, Sergey Nejentsev
Jan 09, 2019
Background: The auto-inflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by a gain-of-function mutation S707Y in the...
APLAID IL-10 IL-1b PLCγ2 auto-inflammatory syndromes cutis laxa sensorineural deafness Amino Acid Sequence Base Sequence Cutis Laxa DNA Mutational Analysis Female Hereditary Autoinflammatory Diseases Humans Immunologic Deficiency Syndromes Infant Newborn Inflammatory Bowel Diseases Male Mutation Missense Pedigree Phospholipase C gamma Sequence Homology Amino Acid
Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension.
Animals Blotting Western Chemokines Disease Models Animal Dose-Response Relationship Drug Gene Expression Regulation Immunohistochemistry Intraocular Pressure Intravitreal Injections Leukocyte Common Antigens Male Ocular Hypertension Phosphatidylinositol 3-Kinases Platelet-Derived Growth Factor RNA Rats Rats Sprague-Dawley Real-Time Polymerase Chain Reaction Retinal Ganglion Cells Synapses
Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 gene through an in silico analysis
RUNX3 encodes a member of the runt domain family of transcription factors. In mammals this family includes three genes (RUNX1-3) and their protein products function as context-dependent transcription factors, either...
RUNX3 encodes a member of the runt domain family of transcription factors. In mammals this family includes three genes (RUNX1-3) and their protein products function as context-dependent transcription factors, either...
Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 gene through an in silico analysis
RUNX3 encodes a member of the runt domain family of transcription factors. In mammals this family includes three genes (RUNX1-3) and their protein products function as context-dependent transcription factors, either...
RUNX3 encodes a member of the runt domain family of transcription factors. In mammals this family includes three genes (RUNX1-3) and their protein products function as context-dependent transcription factors, either...
Saharan dust electrification perceived by a triangle of atmospheric electricity stations in Southern Portugal
HG Silva, F Lopes, S Pereira, Kerianne Nicoll, S M Barbosa, R Conceicao, S Neves, S Neves, Giles Harrison, M Collares Pereira
Dec 01, 2016
Atmospheric Electric Potential Gradient (PG) measurements were carried out in three sites forming a triangular array in Southern Portugal. The campaign was performed during the summer, characterized by Saharan dust outbreaks;...
Molecular characterization of cbfβ gene and identification of new transcription variants
The CBFβ gene encodes a transcription factor that, in combination with CBFα (also called Runx, runt-related transcription factor) regulates expression of several target genes. CBFβ interacts with all Runx family members, such...
Molecular characterization of cbfβ gene and identification of new transcription variants
The CBFβ gene encodes a transcription factor that, in combination with CBFα (also called Runx, runt-related transcription factor) regulates expression of several target genes. CBFβ interacts with all Runx family members, such...
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
Site-selective protein modification strategies can be used to insert non-natural functional groups into protein structures. Herein, we report on the use of the bis-electrophile 3-bromo-2-bromomethyl-1-propene as a reagent to...
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am
Zoltan Szucs, James Joseph, Tim J. Larkin, Bangwen Xie, Sarah E. Bohndiek, Kevin M. Brindle, André A. Neves
Aug 02, 2021
Abstract: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature...
Toward Waveguide-Based Optical Chromatography
We report analytical expressions for optical forces acting on particles inside waveguides. The analysis builds on our previously reported Fourier Transform method to obtain Beam Shape Coefficients for any beam. Here we...
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.
Raquel Conceição, Rachel S Evans, Craig S Pearson, Barbara Hänzi, Andrew Osborne, Sarita S Deshpande, Keith R Martin, Amanda C Barber
Dec 16, 2019
Animals Axon guidance Biomarkers Brain Cues Fatty Acid-Binding Protein 7 Female Gene Expression Regulation Developmental Immunohistochemistry Mice Mice Inbred C57BL Microscopy Confocal Nerve Crush Nerve Tissue Proteins Optic Chiasm Optic Nerve Injuries PAX2 Transcription Factor Pregnancy Retinal Ganglion Cells
Saharan dust electrification perceived by a triangle of atmospheric electricity stations in Southern Portugal
HG Silva, F Lopes, S Pereira, Kerianne Nicoll, S M Barbosa, R Conceicao, S Neves, S Neves, Giles Harrison, M Collares Pereira
Dec 01, 2016
Atmospheric Electric Potential Gradient (PG) measurements were carried out in three sites forming a triangular array in Southern Portugal. The campaign was performed during the summer, characterized by Saharan dust outbreaks;...
“Mind reading” building operation behaviour
Modern buildings are operationally classified as fully naturally ventilated (free running, FR), fully mechanically ventilated and conditioned (air-conditioned, AC) or intermediary (mixed mode, MM). Each strategy implies (i)...
Mixed-mode ventilation Occupant behaviour Office building Thermal Comfort /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
“Mind reading” building operation behaviour
Modern buildings are operationally classified as fully naturally ventilated (free running, FR), fully mechanically ventilated and conditioned (air-conditioned, AC) or intermediary (mixed mode, MM). Each strategy implies (i)...
Mixed-mode ventilation Occupant behaviour Office building Thermal Comfort /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am
Zoltan Szucs, James Joseph, Tim J. Larkin, Bangwen Xie, Sarah E. Bohndiek, Kevin M. Brindle, André A. Neves
Feb 18, 2021
Abstract: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature...
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am.
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A Mendichovszky, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Apr 11, 2023
There is an unmet clinical need for imaging agents capable of detecting early evidence of tumor cell death, since the timing, extent, and distribution of cell death in tumors following treatment can give an indication of...
Published by: Cancers
Metabolic glycan imaging by isonitrile-tetrazine click chemistry.
Shaun Stairs, André A Neves, Henning Stöckmann, Yelena A Wainman, Heather Ireland-Zecchini, Kevin M Brindle, Finian J Leeper
Feb 18, 2019
Seeing the sugar coating: N-Acetyl-glucosamine and mannosamine derivatives tagged with an isonitrile group are metabolically incorporated into cell-surface glycans and can be detected with a fluorescent tetrazine. This...
Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.
Dale J Waterhouse, James Joseph, André A Neves, Massimiliano di Pietro, Kevin M Brindle, Rebecca C Fitzgerald, Sarah E Bohndiek
Aug 23, 2016
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am
Zoltan Szucs, James Joseph, Tim J Larkin, Bangwen Xie, Sarah E Bohndiek, Kevin M Brindle, André A Neves
Feb 03, 2021
BACKGROUND: Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature of DCIS...
Human Cytomegalovirus Interleukin 10 Homologs
Emma Poole, Tainan Cerqueira Neves, Martha Trindade Oliveira, John Sinclair, Maria Cristina Carlan da Silva
Jun 23, 2020
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive)...
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am
Zoltan Szucs, James Joseph, Tim J. Larkin, Bangwen Xie, Sarah E. Bohndiek, Kevin M. Brindle, André A. Neves
Mar 15, 2021
Abstract: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature...
Imaging cell surface glycosylation in vivo using "double click" chemistry.
André A Neves, Henning Stöckmann, Yelena A Wainman, Joe C-H Kuo, Sarah Fawcett, Finian J Leeper, Kevin M Brindle
Nov 26, 2020
Dynamic alterations in cell surface glycosylation occur in numerous biological processes that involve cell-cell communication and cell migration. We report here imaging of cell surface glycosylation in live mice using double...
International variations in primary care physician consultation time
Greg Irving, Ana Luisa Neves, Hajira Dambha-Miller, Ai Oishi, Hiroko Tagashira, Anistasiya Verho, John Holden
Apr 06, 2018
OBJECTIVE: To describe the average primary care physician consultation length in economically developed and low-income/middle-income countries, and to examine the relationship between consultation length and organisational-level...
Development of a Disease-Specific Ureteral Calculus Patient Reported Outcome Measurement Instrument.
Maxine GB Tran, Michal K Sut, Jane Collie, Joana B Neves, Samih Al-Hayek, James N Armitage, Dominique-Laurent Couturier, Oliver J Wiseman
Nov 06, 2018
INTRODUCTION: Patient reported outcome measures (PROMs) are powerful instruments to assess the impact of a disease on health from the patient's perspective. We describe the process of designing, testing, and validating the...
Patient Reported Outcome Measures Quality of life ureteral stones Activities of Daily Living Adult Aged Anxiety fatigue Female Focus Groups Gastrointestinal Diseases Humans Male Middle Aged Pain Patient Reported Outcome Measures Prospective Studies Quality of life Reproducibility of Results Sleep Initiation and Maintenance Disorders Surveys and Questionnaires Ureteral Calculi Urinary Bladder Diseases
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