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A Metaheuristic Optimization Algorithm for Solving Higher-Order Boundary Value Problems
An effective metaheuristic algorithm to solve the higher-order boundary value problems, called a genetic programming technique is presented. In this paper, a genetic programming algorithm, which depends on the syntax tree...
Published by: IGI Global Scientific Publishing
Increased GLP-1 response to oral glucose in pre-pubertal obese children.
Cosimo Giannini, Nicoletta Pietropaoli, Nella Polidori, Francesco Chiarelli, Maria Loredana Marcovecchio, Angelika Mohn
Aug 24, 2018
BACKGROUND: Gastrointestinal hormones, such as glucagon-like peptide (GLP-1), have been hypothesized to play a role in the pathogenesis of obesity-related complications. However, few data are available in youth. The objective of...
Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations.
Wen Shi, Daniel E S Koo, Masahiro Kitano, Hsiao J Chiang, Le A Trinh, Gianluca Turcatel, Benjamin Steventon, Cosimo Arnesano, David Warburton, Scott E Fraser, Francesco Cutrale
Mar 10, 2020
Hyperspectral fluorescence imaging is gaining popularity for it enables multiplexing of spatio-temporal dynamics across scales for molecules, cells and tissues with multiple fluorescent labels. This is made possible by adding...
Published by: Nature Communications
The Disk Wind in GRS 1915+105 as Seen by Insight-Hard X-Ray Modulation Telescope
Abstract
We analyze three observations of GRS 1915+105 in 2017 by Insight–Hard X-ray Modulation Telescope when the source was in a spectrally soft state. We find strong absorption...
Honghui Liu, Yuhan Fu, Cosimo Bambi, Jiachen Jiang, Michael L Parker, Long Ji, Lingda Kong, Liang Zhang, Shu Zhang, Yuexin Zhang
Jul 08, 2022
Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations.
Wen Shi, Daniel ES Koo, Masahiro Kitano, Hsiao J Chiang, Le A Trinh, Gianluca Turcatel, Benjamin Steventon, Cosimo Arnesano, David Warburton, Scott E Fraser, Francesco Cutrale
Feb 04, 2021
Hyperspectral fluorescence imaging is gaining popularity for it enables multiplexing of spatio-temporal dynamics across scales for molecules, cells and tissues with multiple fluorescent labels. This is made possible by adding...
CRISPRi screens reveal genes modulating yeast growth in lignocellulose hydrolysate.
Friederike Gutmann, Cosimo Jann, Filipa Pereira, Andreas Johansson, Lars M Steinmetz, Kiran R Patil
Mar 26, 2021
BACKGROUND: Baker's yeast is a widely used eukaryotic cell factory, producing a diverse range of compounds including biofuels and fine chemicals. The use of lignocellulose as feedstock offers the opportunity to run these...
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.
Cosimo Lobello, Boris Tichy, Vojtech Bystry, Lenka Radova, Daniel Filip, Marek Mraz, Ivonne-Aidee Montes-Mojarro, Nina Prokoph, Hugo Larose, Huan-Chang Liang, Geeta G Sharma, Luca Mologni, David Belada, Katerina Kamaradova, Falko Fend, Carlo Gambacorti-Passerini, Olaf Merkel, Suzanne D Turner, Andrea Janikova, Sarka Pospisilova
Dec 02, 2020
Systemic Anaplastic Large Cell Lymphoma (sALCL) encompasses two distinct clinical entities of T-cell non-Hodgkin lymphoma: Anaplastic Lymphoma Kinase-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL. These entities are...
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis.
Suzanne E Eldridge, Aida Barawi, Hui Wang, Anke J Roelofs, Magdalena Kaneva, Zeyu Guan, Helen Lydon, Bethan L Thomas, Anne-Sophie Thorup, Beatriz F Fernandez, Sara Caxaria, Danielle Strachan, Ahmed Ali, Kanatheepan Shanmuganathan, Costantino Pitzalis, James R Whiteford, Frances Henson, Andrew W McCaskie, Cosimo De Bari, Francesco Dell'Accio
Oct 23, 2020
Cartilage loss leads to osteoarthritis, the most common cause of disability for which there is no cure. Cartilage regeneration, therefore, is a priority in medicine. We report that agrin is a potent chondrogenic factor and that...
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
Cosimo Lobello, Boris Tichy, Vojtech Bystry, Lenka Radova, Daniel Filip, Marek Mraz, Ivonne-Aidee Montes-Mojarro, Nina Prokoph, Hugo Larose, Huan-Chang Liang, Geeta G. Sharma, Luca Mologni, David Belada, Katerina Kamaradova, Falko Fend, Carlo Gambacorti-Passerini, Olaf Merkel, Suzanne D. Turner, Andrea Janikova, Sarka Pospisilova
May 06, 2021
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis.
Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Oct 06, 2020
OBJECTIVES: Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with pain and functional disability. These pathological outgrowths of cartilage and bone typically form at the junction of articular...
CATMoS
Kamel Mansouri, Agnes L Karmaus, Jeremy Fitzpatrick, Grace Patlewicz, Prachi Pradeep, Domenico Alberga, Nathalie Alepee, Timothy EH Allen, Dave Allen, Vinicius M Alves, Carolina H Andrade, Tyler R Auernhammer, Davide Ballabio, Shannon Bell, Emilio Benfenati, Sudin Bhattacharya, Joyce V Bastos, Stephen Boyd, JB Brown, Stephen J Capuzzi, Yaroslav Chushak, Heather Ciallella, Alex M Clark, Viviana Consonni, Pankaj R Daga, Sean Ekins, Sherif Farag, Maxim Fedorov, Denis Fourches, Domenico Gadaleta, Feng Gao, Jeffery M Gearhart, Garett Goh, Jonathan M Goodman, Francesca Grisoni, Christopher M Grulke, Thomas Hartung, Matthew Hirn, Pavel Karpov, Alexandru Korotcov, Giovanna J Lavado, Michael Lawless, Xinhao Li, Thomas Luechtefeld, Filippo Lunghini, Giuseppe F Mangiatordi, Gilles Marcou, Dan Marsh, Todd Martin, Andrea Mauri, Eugene N Muratov, Glenn J Myatt, Dac-Trung Nguyen, Orazio Nicolotti, Reine Note, Paritosh Pande, Amanda K Parks, Tyler Peryea, Ahsan H Polash, Robert Rallo, Alessandra Roncaglioni, Craig Rowlands, Patricia Ruiz, Daniel P Russo, Ahmed Sayed, Risa Sayre, Timothy Sheils, Charles Siegel, Arthur C Silva, Anton Simeonov, Sergey Sosnin, Noel Southall, Judy Strickland, Yun Tang, Brian Teppen, Igor V Tetko, Dennis Thomas, Valery Tkachenko, Roberto Todeschini, Cosimo Toma, Ignacio Tripodi, Daniela Trisciuzzi, Alexander Tropsha, Alexandre Varnek, Kristijan Vukovic, Zhongyu Wang, Liguo Wang, Katrina M Waters, Andrew J Wedlake, Sanjeeva J Wijeyesakere, Dan Wilson, Zijun Xiao, Hongbin Yang, Gergely Zahoranszky-Kohalmi, Alexey V Zakharov, Fagen F Zhang, Zhen Zhang, Tongan Zhao, Hao Zhu, Kimberley M Zorn, Warren Casey, Nicole C Kleinstreuer
May 07, 2021
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis
Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Sep 24, 2020
Understanding 6th-century barbarian social organization and migration through paleogenomics.
Carlos Eduardo G Amorim, Stefania Vai, Cosimo Posth, Alessandra Modi, István Koncz, Susanne Hakenbeck, Maria Cristina La Rocca, Balazs Mende, Dean Bobo, Walter Pohl, Luisella Pejrani Baricco, Elena Bedini, Paolo Francalacci, Caterina Giostra, Tivadar Vida, Daniel Winger, Uta von Freeden, Silvia Ghirotto, Martina Lari, Guido Barbujani, Johannes Krause, David Caramelli, Patrick J Geary, Krishna R Veeramah
Nov 21, 2018
A Paleogenomic Reconstruction of the Deep Population History of the Andes.
Nathan Nakatsuka, Iosif Lazaridis, Chiara Barbieri, Pontus Skoglund, Nadin Rohland, Swapan Mallick, Cosimo Posth, Kelly Harkins-Kinkaid, Matthew Ferry, Éadaoin Harney, Megan Michel, Kristin Stewardson, Jannine Novak-Forst, José M Capriles, Marta Alfonso Durruty, Karina Aranda Álvarez, David Beresford-Jones, Richard Burger, Lauren Cadwallader, Ricardo Fujita, Johny Isla, George Lau, Carlos Lémuz Aguirre, Steven LeBlanc, Sergio Calla Maldonado, Frank Meddens, Pablo G Messineo, Brendan J Culleton, Thomas K Harper, Jeffrey Quilter, Gustavo Politis, Kurt Rademaker, Markus Reindel, Mario Rivera, Lucy Salazar, José R Sandoval, Calogero M Santoro, Nahuel Scheifler, Vivien Standen, Maria Ines Barreto, Isabel Flores Espinoza, Elsa Tomasto-Cagigao, Guido Valverde, Douglas J Kennett, Alan Cooper, Johannes Krause, Wolfgang Haak, Bastien Llamas, David Reich, Lars Fehren-Schmitz
Mar 20, 2020
There are many unanswered questions about the population history of the Central and South Central Andes, particularly regarding the impact of large-scale societies, such as the Moche, Wari, Tiwanaku, and Inca. We assembled...
Circular polarization in the optical afterglow of GRB 121024A
K. Wiersema, S. Covino, K. Toma, A. J. Van Der Horst, K. Varela, M. Min, J. Greiner, R. L. C. Starling, N. R. Tanvir, R. A. M. J. Wijers, S. Campana, P. A. Curran, Y. Fan, J. P. U. Fynbo, J. Gorosabel, A. Gomboc, D. Götz, J. Hjorth, Z. P. Jin, S. Kobayashi, C. Kouveliotou, C. Mundell, P. T. O’Brien, E. Pian, A. Rowlinson, D. M. Russell, R. Salvaterra, S. Di Serego Alighieri, G. Tagliaferri, S. D. Vergani, J. Elliott, C. Fariña, O. E. Hartoog, R. Karjalainen, S. Klose, F. Knust, A. J. Levan, P. Schady, V. Sudilovsky, R. Willingale
May 08, 2014
Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium....
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Jul 29, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Animals Basic-Leucine Zipper Transcription Factors Cell Line Tumor Cell Proliferation Cell Survival Gene Expression Regulation Neoplastic Humans Immunoconjugates Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Ki-1 Antigen Lymphoma Large-Cell Anaplastic Mice Receptors Interleukin-2 Regulatory Sequences Nucleic Acid Repressor Proteins Signal Transduction Xenograft Model Antitumor Assays
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Oct 24, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Published by: Nature Communications
Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Hugo Larose, Nina Prokoph, Jamie D Matthews, Michaela Schlederer, Sandra Högler, Ali F Alsulami, Stephen P Ducray, Edem Nuglozeh, Feroze MS Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L Blundell, Wolfram Klapper, Olaf Merkel, Amos GA Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D Turner
Apr 06, 2020
Circular polarization in the optical afterglow of GRB 121024A
K. Wiersema, S. Covino, K. Toma, A. J. Van Der Horst, K. Varela, M. Min, J. Greiner, R. L. C. Starling, N. R. Tanvir, R. A. M. J. Wijers, S. Campana, P. A. Curran, Y. Fan, J. P. U. Fynbo, J. Gorosabel, A. Gomboc, D. Götz, J. Hjorth, Z. P. Jin, S. Kobayashi, C. Kouveliotou, C. Mundell, P. T. O’Brien, E. Pian, A. Rowlinson, D. M. Russell, R. Salvaterra, S. Di Serego Alighieri, G. Tagliaferri, S. D. Vergani, J. Elliott, C. Fariña, O. E. Hartoog, R. Karjalainen, S. Klose, F. Knust, A. J. Levan, P. Schady, V. Sudilovsky, R. Willingale
May 08, 2014
Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium....
The evolution and changing ecology of the African hominid oral microbiome.
James A Fellows Yates, Irina M Velsko, Franziska Aron, Cosimo Posth, Courtney A Hofman, Rita M Austin, Cody E Parker, Allison E Mann, Kathrin Nägele, Kathryn Weedman Arthur, John W Arthur, Catherine C Bauer, Isabelle Crevecoeur, Christophe Cupillard, Matthew C Curtis, Love Dalén, Marta Díaz-Zorita Bonilla, J Carlos Díez Fernández-Lomana, Dorothée G Drucker, Elena Escribano Escrivá, Michael Francken, Victoria E Gibbon, Manuel R González Morales, Ana Grande Mateu, Katerina Harvati, Amanda G Henry, Louise Humphrey, Mario Menéndez, Dušan Mihailović, Marco Peresani, Sofía Rodríguez Moroder, Mirjana Roksandic, Hélène Rougier, Sandra Sázelová, Jay T Stock, Lawrence Guy Straus, Jiří Svoboda, Barbara Teßmann, Michael J Walker, Robert C Power, Cecil M Lewis, Krithivasan Sankaranarayanan, Katerina Guschanski, Richard W Wrangham, Floyd E Dewhirst, Domingo C Salazar-García, Johannes Krause, Alexander Herbig, Christina Warinner
Jun 11, 2021
The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing...
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