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Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I.
Franziska Nuber, Johannes Schimpf, Jean-Paul di Rago, Déborah Tribouillard-Tanvier, Vincent Procaccio, Marie-Laure Martin-Negrier, Aurélien Trimouille, Olivier Biner, Christoph von Ballmoos, Thorsten Friedrich
Jul 28, 2021
NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in energy metabolism by coupling electron transfer from NADH to quinone with proton translocation across the membrane. Complex I deficiencies were found...
Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I
Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of...