The initial state of the intrinsically disordered protein α-synuclein (aSyn), e.g., the presence of oligomers and degradation products, or the presence of contaminants and adducts can greatly influence the aggregation kinetics...
Native nanoelectrospray ionization mass spectrometry is an underutilized technique for fragment screening. In this study, the first demonstration is provided of the use of native mass spectrometry for screening fragments against...
Background
Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as...
BACKGROUND: Randomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status...
Abstract: A measurement of four branching-fraction ratios for three-body decays of B mesons involving two open-charm hadrons in the final state is presented. Run 1 and Run 2 pp collision data are used, recorded by the LHCb...
Abstract: The first full angular analysis of the B0→D∗−Ds∗+ decay is performed using 6 fb−1 of pp collision data collected with the LHCb experiment at a centre-of-mass energy of 13 TeV. The Ds∗+→Ds+γ and D*− → D¯0π− vector meson...
Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the human host....
The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA metabolism of Escherichia coli and numerous other bacterial species including pathogens. At the core of the assembly is the endoribonuclease...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
A measurement of four branching-fraction ratios for three-body decays of $B$
mesons involving two open-charm hadrons in the final state is presented. Run 1
and Run 2 $pp$ collision data are used, recorded by the LHCb experiment...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to...
Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods...
A search for the $B^0_s \!\rightarrow D^{*\pm} D^\mp$ decay is performed
using proton-proton collision data at centre-of-mass energies of $7$, $8$ and
$13\,\text{TeV}$ collected by the LHCb experiment, corresponding to...
Measurements of $CP$ observables in $B^\pm \to D K^\pm$ and $B^\pm \to D
\pi^\pm$ decays are presented, where $D$ represents a superposition of $D^0$
and $\bar{D}^0$ states. The $D$ meson is reconstructed in the three-body...
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive...