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Healthcare and Social-Services Institutions in the Face of Radical Differences
When people at risk of discrimination on multiple grounds or experiencing identity-based oppression meet healthcare and social services, their complex life stories often result in mistrust and prejudice. The aim of this article...
Published by: Memorial University of Newfoundland
Healthcare and Social-Services Institutions in the Face of Radical Differences
When people at risk of discrimination on multiple grounds or experiencing identity-based oppression meet healthcare and social services, their complex life stories often result in mistrust and prejudice. The aim of this article...
Published by: Memorial University of Newfoundland
Autism and education-Teacher policy in Europe
Robin van Kessel, Paula Steinhoff, Orsolya Varga, Dagmar Breznoščáková, Katarzyna Czabanowska, Carol Brayne, Simon Baron-Cohen, Andres Roman-Urrestarazu
Aug 19, 2020
BACKGROUND: This report maps autism and special education needs (SEN) policies, alongside teacher responsibilities in the education of children with SEN in Austria, Hungary, Czech Republic, and Slovakia. METHODS AND PROCEDURE: A...
Optimizing Patient Management and Adherence for Children Receiving Growth Hormone.
Poor adherence with growth hormone (GH) therapy has been associated with worse clinical outcomes, which in children relates specifically to their linear growth and loss of quality of life. The "360° GH in Europe" meeting, held...
Volumetric measurements of paranasal sinuses and examination of sinonasal communication in healthy Shetland ponies
Lisa Köhler, Ellen Schulz-Kornas, Ingrid Vervuert, Claudia Gittel, Karsten Winter, Dagmar Berner, Kerstin Gerlach
Jan 21, 2021
BACKGROUND: Despite clinical importance and frequent occurrence of sinus disease, little is known about the size of paranasal sinuses and their communication in ponies and small horses. To examine the shape and volume of the...
Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos.
L Carine Stapel, Benoit Lombardot, Coleman Broaddus, Dagmar Kainmueller, Florian Jug, Eugene W Myers, Nadine L Vastenhouw
Jun 28, 2019
Analysis of differential gene expression is crucial for the study of cell fate and behavior during embryonic development. However, automated methods for the sensitive detection and quantification of RNAs at cellular resolution...
An anatomical study of the dorsal and ventral nasal conchal bullae and middle nasal conchae in normal Shetland ponies
Kerstin Gerlach, Ingrid Vervuert, Claudia Gittel, Lisa Köhler, Nane Schmidt, Karsten Winter, Dagmar Berner, Antonia Troillet, Ellen Schulz-Kornas
May 21, 2021
Equine paranasal sinuses are susceptible to inflammation. Insufficient drainage through the nasal passages and meatus may lead to the accumulation of inspissated purulent discharge. Particularly in ponies, these anatomical...
Solving unsolved rare neurological diseases-a Solve-RD viewpoint.
Rebecca Schüle, Dagmar Timmann, Corrie E Erasmus, Jennifer Reichbauer, Melanie Wayand, Solve-RD-DITF-RND, Bart van de Warrenburg, Ludger Schöls, Carlo Wilke, Andrea Bevot, Stephan Zuchner, Sergi Beltran, Steven Laurie, Leslie Matalonga, Holm Graessner, Matthis Synofzik, Solve-RD Consortium
Sep 15, 2021
SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.
Chi Huu Nguyen, Tobias Glüxam, Angela Schlerka, Katharina Bauer, Alexander M Grandits, Hubert Hackl, Oliver Dovey, Sabine Zöchbauer-Müller, Jonathan L Cooper, George S Vassiliou, Dagmar Stoiber, Rotraud Wieser, Gerwin Heller
Jul 25, 2019
Acute myeloid leukemia (AML) is a heterogeneous disease with respect to its genetic and molecular basis and to patients´ outcome. Clinical, cytogenetic, and mutational data are used to classify patients into risk groups with...
'If I am on ART, my new-born baby should be put on treatment immediately'
Maggie Nyirenda-Nyang'wa, Moses Kelly Kumwenda, Shona Horter, Mina C Hosseinipour, Maganizo Chagomerana, Neil Kennedy, Derek Fairley, Kevin Mortimer, Victor Mwapasa, Chisomo Msefula, Nigel Klein, Dagmar Alber, Angela Obasi
Mar 10, 2023
Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.
Binyamin Duethorn, Fabian Groll, Bettina Rieger, Hannes CA Drexler, Heike Brinkmann, Ludmila Kremer, Martin Stehling, Marie-Theres Borowski, Karina Mildner, Dagmar Zeuschner, Magdalena Zernicka-Goetz, Marc P Stemmler, Karin B Busch, Juan M Vaquerizas, Ivan Bedzhov
Feb 01, 2022
Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the...
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.
Binyamin Duethorn, Fabian Groll, Bettina Rieger, Hannes CA Drexler, Heike Brinkmann, Ludmila Kremer, Martin Stehling, Marie-Theres Borowski, Karina Mildner, Dagmar Zeuschner, Magdalena Zernicka-Goetz, Marc P Stemmler, Karin B Busch, Juan M Vaquerizas, Ivan Bedzhov
Mar 05, 2022
Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the...
Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.
Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel AB Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H Waterman, Michael Zimmermann, Paul M Stewart, John Wright, Mark Mon-Williams, Darren Charles Greenwood, Laura J Hardie
Jun 11, 2021
BACKGROUND: Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on...
Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort
Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A. Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel A. B. Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H. Waterman, Michael Zimmermann, Paul M. Stewart, John Wright, Mark Mon-Williams, Darren Charles Greenwood, Laura J. Hardie
Jun 11, 2020
Abstract: Background: Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects...
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
Maternal iodine status in a multi-ethnic UK birth cohort
Kirsten Jade Cromie, Diane Erin Threapleton, Charles Jonathan Peter Snart, Elizabeth Taylor, Dan Mason, Barry Wright, Brian Kelly, Stephen Reid, Rafaq Azad, Claire Keeble, Amanda H Waterman, Sarah Meadows, Amanda McKillion, Nisreen A Alwan, Janet Elizabeth Cade, Nigel AB Simpson, Paul M Stewart, Michael Zimmermann, John Wright, Dagmar Waiblinger, Mark Mon-Williams, Laura J Hardie, Darren Charles Greenwood
Dec 05, 2020
BACKGROUND: Maternal iodine requirements increase during pregnancy to supply thyroid hormones essential for fetal brain development. Maternal iodine deficiency can lead to hypothyroxinemia, a reduced fetal supply of thyroid...
Optimising Exome Prenatal Sequencing Services (EXPRESS): a study protocol to evaluate rapid prenatal exome sequencing in the NHS Genomic Medicine Service [version 2; peer review
Melissa Hill, Sian Ellard, Jane Fisher, Naomi Fulop, Marian Knight, Mark Kroese, Jean Ledger, Kerry Leeson-Beevers, Alec McEwan, Dominic McMullan, Rhiannon Mellis, Stephen Morris, Michael Parker, Dagmar Tapon, Emma Baple, Laura Blackburn, Asya Choudry, Caroline Lafarge, Hannah McInnes-Dean, Michelle Peter, Rema Ramakrishnan, Lauren Roberts, Beverly Searle, Emma Smith, Holly Walton, Sarah L Wynn, Wing Han Wu, Lyn S Chitty
Sep 07, 2022
BACKGROUND: Prenatal exome sequencing (ES) for the diagnosis of fetal anomalies was implemented nationally in England in October 2020 by the NHS Genomic Medicine Service (GMS). The GMS is based around seven regional Genomic...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
The ARCA Registry
Andreas Traschütz, Selina Reich, Astrid D. Adarmes, Mathieu Anheim, Mahmoud Reza Ashrafi, Jonathan Baets, A. Nazli Basak, Enrico Bertini, Bernard Brais, Cynthia Gagnon, Janina Gburek-Augustat, Hasmet A. Hanagasi, Anna Heinzmann, Rita Horvath, Peter De Jonghe, Christoph Kamm, Peter Klivenyi, Thomas Klopstock, Martina Minnerop, Alexander Münchau, Mathilde Renaud, Richard H. Roxburgh, Filippo M. Santorelli, Tommaso Schirinzi, Deborah A. Sival, Dagmar Timmann, Stefan Vielhaber, Michael Wallner, Bart P. van de Warrenburg, Ginevra Zanni, Stephan Zuchner, Thomas Klockgether, Rebecca Schüle, Ludger Schöls, PREPARE Consortium, Matthis Synofzik
Jul 28, 2021
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of...
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Christina Sternberg, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich Jäger, Philipp B Staber, Florian Grebien, Richard Moriggl, Mathias Müller, Giorgio G Inghirami, Takaomi Sanda, A Thomas Look, Suzanne D Turner, Lukas Kenner, Olaf Merkel
Nov 06, 2018
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic...
Anaplastic Lymphoma Kinase Animals Apoptosis Cell Line Tumor Cell Survival Gene Expression Regulation Neoplastic Humans Lymphoma Large-Cell Anaplastic Mice Myeloid Cell Leukemia Sequence 1 Protein Phosphorylation Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT1 Transcription Factor STAT3 Transcription Factor Signal Transduction TYK2 Kinase Translocation Genetic
Mapping past human land use using archaeological data
Kathleen D. Morrison, Emily Hammer, Oliver Boles, Marco Madella, Nicola Whitehouse, Marie-Jose Gaillard, Jennifer Bates, Marc Vander Linden, Stefania Merlo, Alice Yao, Laura Popova, Austin Chad Hill, Ferran Antolin, Andrew Bauer, Stefano Biagetti, Rosie R. Bishop, Phillip Buckland, Pablo Cruz, Dagmar Dreslerová, Gerrit Dusseldorp, Erle Ellis, Dragana Filipovic, Thomas Foster, Matthew J. Hannaford, Sandy P. Harrison, Manjil Hazarika, Hajnalka Herold, Johanna Hilpert, Jed O. Kaplan, Andrea Kay, Kees Klein Goldewijk, Jan Kolář, Elizabeth Kyazike, Julian Laabs, Carla Lancelotti, Paul Lane, Dan Lawrence, Krista Lewis, Umberto Lombardo, Giulio Lucarini, Manuel Arroyo-Kalin, Rob Marchant, Francis Mayle, Meriel McClatchie, Madeleine McLeester, Scott Mooney, Magdalena Moskal-Del Hoyo, Vanessa Navarrete, Emmanuel Ndiema, Eduardo Góes Neves, Marek Nowak, Welmoed A. Out, Cameron Petrie, Leanne N. Phelps, Zsolt Pinke, Stéphen Rostain, Thembi Russell, Andrew Sluyter, Amy K. Styring, Eduardo Tamanaha, Evert Thomas, Selvakumar Veerasamy, Lynn Welton, Marco Zanon
Apr 14, 2021
In the 12,000 years preceding the Industrial Revolution, human activities led to significant changes in land cover, plant and animal distributions, surface hydrology, and biochemical cycles. Earth system models suggest that this...
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Jul 29, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Animals Basic-Leucine Zipper Transcription Factors Cell Line Tumor Cell Proliferation Cell Survival Gene Expression Regulation Neoplastic Humans Immunoconjugates Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Ki-1 Antigen Lymphoma Large-Cell Anaplastic Mice Receptors Interleukin-2 Regulatory Sequences Nucleic Acid Repressor Proteins Signal Transduction Xenograft Model Antitumor Assays
The ARCA Registry
Andreas Traschütz, Selina Reich, Astrid D Adarmes, Mathieu Anheim, Mahmoud Reza Ashrafi, Jonathan Baets, A Nazli Basak, Enrico Bertini, Bernard Brais, Cynthia Gagnon, Janina Gburek-Augustat, Hasmet A Hanagasi, Anna Heinzmann, Rita Horvath, Peter De Jonghe, Christoph Kamm, Peter Klivenyi, Thomas Klopstock, Martina Minnerop, Alexander Münchau, Mathilde Renaud, Richard H Roxburgh, Filippo M Santorelli, Tommaso Schirinzi, Deborah A Sival, Dagmar Timmann, Stefan Vielhaber, Michael Wallner, Bart P van de Warrenburg, Ginevra Zanni, Stephan Zuchner, Thomas Klockgether, Rebecca Schüle, Ludger Schöls, PREPARE Consortium, Matthis Synofzik
Aug 17, 2021
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of...
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Oct 24, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Published by: Nature Communications
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