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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.
The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process-the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become...
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become...
When Bio Meets Technology
Amy E Rochford, Alejandro Carnicer-Lombarte, Vincenzo F Curto, George G Malliaras, Damiano G Barone
Aug 29, 2019
Ossification of the pterygoalar and pterygospinous ligaments
Tomasz Matys, Tariq Ali, Fulvio Zaccagna, Damiano G Barone, Ramez W Kirollos, Tarik F Massoud
May 24, 2019
OBJECTIVE: Ossification of pterygoalar and pterygospinous ligaments traversing the superior aspect of the infratemporal fossa results in formation of osseous bars that can obstruct percutaneous needle access to the trigeminal...
Brain monitoring
Published by: TheScientificWorldJournal
3D Bioelectronics with a Remodellable Matrix for Long-Term Tissue Integration and Recording.
Alexander J Boys, Alejandro Carnicer-Lombarte, Amparo Güemes-Gonzalez, Douglas C van Niekerk, Sam Hilton, Damiano G Barone, Christopher M Proctor, Róisín M Owens, George G Malliaras
Dec 21, 2022
Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long-term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates...
Electronics with shape actuation for minimally invasive spinal cord stimulation.
Ben J Woodington, Vincenzo F Curto, Yi-Lin Yu, Héctor Martínez-Domínguez, Lawrence Coles, George G Malliaras, Christopher M Proctor, Damiano G Barone
May 06, 2021
Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and...
Brain-Machine Interfaces
Aswin Chari, Sanjay Budhdeo, Rachel Sparks, Damiano G Barone, Hani J Marcus, Erlick Ac Pereira, Martin M Tisdall
Dec 03, 2020
The neurotechnology field is set to expand rapidly in the coming years as technological innovations in hardware and software are translated to the clinical setting. Given our unique access to patients with neurological...
Large Animal Studies to Reduce the Foreign Body Reaction in Brain-Computer Interfaces
Shan Yasin Mian, Jonathan Roy Honey, Alejandro Carnicer-Lombarte, Damiano Giuseppe Barone
Nov 01, 2021
Brain-computer interfaces (BCI) are reliant on the interface between electrodes and neurons to function. The foreign body reaction (FBR) that occurs in response to electrodes in the brain alters this interface and may pollute...
Electronics with shape actuation for minimally invasive spinal cord stimulation.
Ben J Woodington, Vincenzo F Curto, Yi-Lin Yu, Héctor Martínez-Domínguez, Lawrence Coles, George G Malliaras, Christopher M Proctor, Damiano G Barone
Jul 28, 2021
Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and...
Published by: Science advances
Large Animal Studies to Reduce the Foreign Body Reaction in Brain–Computer Interfaces
Shan Yasin Mian, Jonathan Roy Honey, Alejandro Carnicer-Lombarte, Damiano Giuseppe Barone
Aug 17, 2021
Brain–computer interfaces (BCI) are reliant on the interface between electrodes and neurons to function. The foreign body reaction (FBR) that occurs in response to electrodes in the brain alters this interface and may pollute...
X-Ray Markers for Thin Film Implants.
Ben J Woodington, Lawrence Coles, Amy E Rochford, Paul Freeman, Stephen Sawiak, Stephen JK O'Neill, Oren A Scherman, Damiano G Barone, Christopher M Proctor, George G Malliaras
Aug 08, 2022
Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics.
Amy E Rochford, Alejandro Carnicer-Lombarte, Malak Kawan, Amy Jin, Sam Hilton, Vincenzo F Curto, Alexandra L Rutz, Thomas Moreau, Mark R N Kotter, George G Malliaras, Damiano G Barone
Apr 17, 2023
The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating and restoring neurological functions in the nervous system. A critical factor is to increase the...
Published by: Science advances
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Methodological shortcomings in the literature evaluating the role and applications of 3D training for surgical trainees.
Milosz Kostusiak, Michael Hart, Damiano Giuseppe Barone, Riikka Hofmann, Ramez Kirollos, Thomas Santarius, Rikin Trivedi
May 29, 2019
AIM: There has been an increased interest in the use of three-dimensional (3D) technology in surgical training. We wish to appraise the methodological rigor applied to evaluating the role and applications of 3D technology in...
Academic neurosurgery in the UK
Mueez Waqar, Benjamin M Davies, Rasheed Zakaria, Damiano G Barone, Angelos G Kolias, Kenny K Yu, Jonathan R Ellenbogen, Paul M Brennan, Mark RN Kotter, William P Gray, Andrew T King, Carole Turner, Neil Kitchen, Paul May, Michael D Jenkinson, Peter J Hutchinson
Jul 03, 2019
Academic neurosurgery encompasses basic science and clinical research efforts to better understand and treat diseases of relevance to neurosurgical practice, with the overall aim of improving treatment and outcome for patients....
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Prevention of the foreign body response to implantable medical devices by inflammasome inhibition.
Damiano G Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S Hamilton, Malwina Prater, Alexandra L Rutz, Ivan B Dimov, George G Malliaras, Stephanie P Lacour, Avril Ab Robertson, Kristian Franze, James W Fawcett, Clare E Bryant
Apr 19, 2022
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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