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Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Dr. Daniel F. Mahony Selected as President of Winthrop University
Winthrop University
Jan 01, 0001
Mahony will begin his duties on July 1, 2015. The President's House will be home to Mahony, his wife Laura and their two children, Gavin, 15, and Elena, 12. Dr. Daniel F. Mahony, dean of the College of Education, Health and...
Published by: Winthrop University
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
The PI3K pathway has emerged as a key regulator of regulatory T cell (Treg) development and homeostasis and is required for full Treg-mediated suppression. To identify new genes involved in PI3K-dependent suppression, we...
ADP-ribosyl Cyclase 1 adenine Animals Cell Proliferation Class I Phosphatidylinositol 3-Kinases Forkhead Transcription Factors Gene Expression Profiling Gene Expression Regulation Genome Lymphocyte Subsets Mice Phosphatidylinositol 3-Kinases Quinazolines RNA Messenger T-Lymphocytes Regulatory Tretinoin
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park, Rachel A Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, Kenny Roberts, Veronika R Kedlian, John R Ferdinand, Xiaoling He, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa T Mahbubani, Krzysztof Polanski, Lira Mamanova, Liam Bolt, David Crossland, Fabrizio de Rita, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Omer A Bayraktar, Roger A Barker, Kerstin B Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A Teichmann
Mar 19, 2020
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell...
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been postulated that they may also be involved in inducing peripheral tolerance. To examine the function of DCs in the steady state we devised an...
Published by: Rockefeller University
McShane on the Transformation of Botany
Daniel Mayer
Mar 16, 2022
Daniel Mayer, leadership educator and researcher into the epistemology of biology, has long reflected on the nature of organization, both of organisms and of organizations. This is the topic of his recently completed PhD...
Published by: Memorial University of Newfoundland
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Daring to Stretch toward the Ultimate Consummation
Daniel Helminiak
Mar 16, 2022
Daniel A. Helminiak is Emeritus Professor of Psychology, University of West Georgia. He holds PhDs in theology and psychology and has published widely in these fields and their applications to spirituality and sexuality. Among...
Published by: Memorial University of Newfoundland
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
A trade-off between cognitive and physical performance, with relative preservation of brain function.
Debate surrounds the issue of how the large, metabolically expensive brains of Homo sapiens can be energetically afforded. At the evolutionary level, decreased investment in muscularity, adiposity and the digestive tract allow...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Lorna B Jarvis, Daniel B Rainbow, Valerie Coppard, Sarah K Howlett, Zoya Georgieva, Jessica L Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T Grist, Alasdair J Coles, Hani S Mousa, Stefano Pluchino, Krishnaa T Mahbubani, Julian L Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S Wicker, Joanne L Jones
Nov 22, 2021
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is...
Published by: Communications biology
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
McShane on the Transformation of Botany
Daniel Mayer
Mar 16, 2022
Daniel Mayer, leadership educator and researcher into the epistemology of biology, has long reflected on the nature of organization, both of organisms and of organizations. This is the topic of his recently completed PhD...
Published by: Memorial University of Newfoundland
Daring to Stretch toward the Ultimate Consummation
Daniel Helminiak
Mar 16, 2022
Daniel A. Helminiak is Emeritus Professor of Psychology, University of West Georgia. He holds PhDs in theology and psychology and has published widely in these fields and their applications to spirituality and sexuality. Among...
Published by: Memorial University of Newfoundland
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling, Mariana O Diniz, Nathalie M Schmidt, Oliver E Amin, Aneesh Chandran, Emily Shaw, Corinna Pade, Joseph M Gibbons, Nina Le Bert, Anthony T Tan, Anna Jeffery-Smith, Cedric CS Tan, Christine YL Tham, Stephanie Kucykowicz, Gloryanne Aidoo-Micah, Joshua Rosenheim, Jessica Davies, Marina Johnson, Melanie P Jensen, George Joy, Laura E McCoy, Ana M Valdes, Benjamin M Chain, David Goldblatt, Daniel M Altmann, Rosemary J Boyton, Charlotte Manisty, Thomas A Treibel, James C Moon, COVIDsortium Investigators, Lucy van Dorp, Francois Balloux, Áine McKnight, Mahdad Noursadeghi, Antonio Bertoletti, Mala K Maini
Jan 28, 2022
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Being Native American in Business
Daniel Daniel Stewart, Amy K. Verbos, Carolyn Birmingham, Stephanie L. Black, Joseph Gladstone
Jan 01, 2017
Tribally-owned American Indian enterprises provide a unique cross-cultural setting for emerging Native American business leaders. This paper examines the manner in which American Indian leaders negotiate the boundaries between...
Native American leadership authentic leadership collective identity American Indian culture international business leadership Business Administration management and Operations Indigenous Studies
Published by: Digital Commons @ Texas A&M University-San Antonio
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