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Cover Image for A comparison of clinical examination and ultrasound enthesitis indices in patients with psoriatic arthritis, adjusted for concomitant fibromyalgia

A comparison of clinical examination and ultrasound enthesitis indices in patients with psoriatic arthritis, adjusted for concomitant fibromyalgia

Mark Sapsford, Jobie Evans, Gavin Clunie, Deepak Jadon

Mar 30, 2021

Objectives:: To: (a) determine the extent of ultrasound (US)-detected peripheral enthesitis in a cohort of patients with psoriatic arthritis (PsA); (b) compare this with three clinical examination (CE) enthesitis indices; and...

Original Research enthesitis fibromyalgia musculoskeletal ultrasound psoriatic arthritis

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Multidisciplinary working in the management of axial and peripheral spondyloarthritis.

Tania Gudu, Deepak R Jadon

Jan 18, 2021

Multidisciplinary (MD) care is essential in the management of patients with spondyloarthritis (SpA) and is one of the main pillars of disease management and patient care. However, evidence supporting the effectiveness and...

combined clinics multidisciplinary team meetings multidisciplinary working spondyloarthritis

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Multidisciplinary working in the management of axial and peripheral spondyloarthritis

Tania Gudu, Deepak R. Jadon

Dec 22, 2020

Extra-articular manifestations and comorbidities in spondyloarthritis combined clinics multidisciplinary team meetings multidisciplinary working spondyloarthritis

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MULTIDISCIPLINARY WORKING IN THE MANAGEMENT OF AXIAL AND PERIPHERAL SPONDYLOARTHRITIS

Tania Gudu, Deepak R Jadon

Nov 10, 2020

Arthritis psoriasis Digestive Diseases Autoimmune Disease Clinical Research 7.1 Individual care needs 7 Management of diseases and conditions Inflammatory and immune system 3 Good Health and Well Being

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Serum Soluble Bone Turnover Biomarkers in Psoriatic Arthritis and Psoriatic Spondyloarthropathy

Deepak R Jadon, Alison L Nightingale, Neil J McHugh, Mark A Lindsay, Eleanor Korendowych, Raj Sengupta

Jan 01, 2015

Because psoriatic arthritis (PsA) is an inflammatory disease of joints, serum soluble biomarkers specific for chronic joint and bone inflammation may predict future disease severity and response to therapy, thereby informing...

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Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging

Jobie Evans, Mark Sapsford, Scott McDonald, Kenneth Poole, Tim Raine, Deepak R Jadon

Apr 12, 2021

BACKGROUND: Patients with inflammatory bowel disease (IBD) have an excess burden of axial spondyloarthritis (axSpA), which, if left untreated, may significantly impact on clinical outcomes. We aimed to estimate the prevalence of...

Crohn’s Disease Ankylosing spondylitis Computed tomography enteropathic arthritis inflammatory bowel disease Magnetic Resonance Imaging spondyloarthritis Ulcerative colitis

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Composite Measures for Clinical Trials in Psoriatic Arthritis

W Tillett, Deepak Jadon, Adwaye Rambojun, Neil McHugh

Jun 01, 2021

OBJECTIVE: To test the addition of pain and fatigue to the Composite Psoriatic Arthritis Disease Activity (CPDAI) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite Exercise (GRACE) composite...

GRAPPA psoriasis psoriatic arthritis

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Composite Measures for Routine Clinical Practice in Psoriatic Arthritis

W Tillett, Deepak Jadon, Neil McHugh, Adwaye Rambojun

Jun 01, 2021

OBJECTIVE: To test shortened versions of the psoriatic arthritis (PsA) composite measures for use in routine clinical practice.

METHODS: Clinical and patient-reported outcome measures (PROMs) were assessed in patients...

GRAPPA outcome measures psoriatic arthritis

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Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis

Conor Magee, Hannah Jethwa, Oliver M FitzGerald, Deepak R Jadon

Jun 17, 2021

Aims

The ability to predict response to treatment remains a key unmet need in psoriatic disease. We conducted a systematic review of studies relating to biomarkers associated with response to treatment in either...

psoriasis therapeutics psoriatic arthritis Biological Therapy DMARD drug response biomarkers

Published by: Therapeutic advances in musculoskeletal disease

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Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis

Conor Magee, Hannah Jethwa, Oliver M. FitzGerald, Deepak R. Jadon

May 10, 2021

Aims:: The ability to predict response to treatment remains a key unmet need in psoriatic disease. We conducted a systematic review of studies relating to biomarkers associated with response to treatment in either psoriasis...

review article Biological Therapy DMARD drug response biomarkers psoriatic arthritis psoriasis therapeutics

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Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis

Conor Magee, Hannah Jethwa, Oliver M FitzGerald, Deepak R Jadon

Jul 12, 2021

AIMS: The ability to predict response to treatment remains a key unmet need in psoriatic disease. We conducted a systematic review of studies relating to biomarkers associated with response to treatment in either psoriasis...

DMARD Biological Therapy drug response biomarkers psoriasis psoriatic arthritis therapeutics

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A comparison of clinical examination and ultrasound enthesitis indices in patients with psoriatic arthritis, adjusted for concomitant fibromyalgia.

Mark Sapsford, Jobie Evans, Gavin Clunie, Deepak Jadon

May 11, 2021

enthesitis fibromyalgia musculoskeletal ultrasound psoriatic arthritis

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The Benefits and Challenges of Setting Up a Longitudinal Psoriatic Arthritis Database

Dafna D Gladman, Laura C Coates, Deepak R Jadon, William Tillett, Philip J Mease, Marijn Vis

Jun 01, 2018

The members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) have shown great interest in developing a common GRAPPA database. To address this interest, GRAPPA included a symposium at its...

Databases GRAPPA Prognosis psoriasis psoriatic arthritis Registries

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Unmet needs in psoriatic arthritis.

Beverly Cheok Kuan Ng, Deepak Rohit Jadon

Jul 22, 2021

Biomarkers Precision Medicine Prognosis psoriatic arthritis Arthritis Psoriatic Delayed Diagnosis Diagnostic Imaging Disease Progression Humans Precision Medicine

Cover Image for Trajectory of radiographic change over a decade

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Depression in patients with spondyloarthritis

Joel T. Parkinson, Éimear M. Foley, Deepak R. Jadon, Golam M. Khandaker

Nov 09, 2020

Extra-articular manifestations and comorbidities in spondyloarthritis Ankylosing spondylitis assessment Depression Depressive Disorder EPIDEMIOLOGY psoriatic arthritis spondyloarthritis Treatment

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Depression in patients with spondyloarthritis

Joel T Parkinson, Éimear M Foley, Deepak R Jadon, Golam M Khandaker

Oct 13, 2020

Depression is a major neuropsychiatric disorder common in patients with rheumatological conditions including spondyloarthritis (SpA). It is associated with higher disease activity, functional impairment, poor treatment response...

Ankylosing spondylitis assessment Depression Depressive Disorder EPIDEMIOLOGY psoriatic arthritis spondyloarthritis Treatment

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Psoriatic Arthritis Mutilans

Deepak R Jadon, Gavin Shaddick, William Tillett, Eleanor Korendowych, Graham Robinson, Nicola Waldron, Charlotte Cavill, Neil J McHugh

May 15, 2015

OBJECTIVE: (1) To compare clinical characteristics of patients with psoriatic arthritis (PsA) with PsA mutilans (PAM) and without PAM, and (2) to determine the rate of PAM radiographic progression.

METHODS: A...

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Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging

Jobie Evans, Mark Sapsford, Scott McDonald, Kenneth Poole, Tim Raine, Deepak R. Jadon

Mar 13, 2021

Background:: Patients with inflammatory bowel disease (IBD) have an excess burden of axial spondyloarthritis (axSpA), which, if left untreated, may significantly impact on clinical outcomes. We aimed to estimate the prevalence...

Systematic review Ankylosing spondylitis Computed tomography Crohn’s Disease enteropathic arthritis inflammatory bowel disease Magnetic Resonance Imaging spondyloarthritis Ulcerative colitis

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Novel Composite Radiographic Score for Longitudinal Observational Studies of Psoriatic Arthritis

William Tillett, Gavin Shaddick, Deepak Jadon, Graham Robinson, Eleanor Korendowych, Neil McHugh

Jan 15, 2016

OBJECTIVE: To devise a feasible composite radiographic score for use in observational studies of psoriatic arthritis (PsA).

METHODS: Radiographs from 50 patients with PsA were evaluated with the PsA-modified Sharp...

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Composite Measures for Routine Clinical Practice in Psoriatic Arthritis

W Tillett, Deepak Jadon, Neil McHugh, Adwaye Rambojun

Jun 01, 2021

OBJECTIVE: To test shortened versions of the psoriatic arthritis (PsA) composite measures for use in routine clinical practice.

METHODS: Clinical and patient-reported outcome measures (PROMs) were assessed in patients...

GRAPPA outcome measures psoriatic arthritis

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Composite Measures for Clinical Trials in Psoriatic Arthritis

W Tillett, Deepak Jadon, Adwaye Rambojun, Neil McHugh

Jun 01, 2021

GRAPPA psoriasis psoriatic arthritis

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The Benefits and Challenges of Setting Up a Longitudinal Psoriatic Arthritis Database.

Dafna D Gladman, Laura C Coates, Deepak R Jadon, William Tillett, Philip J Mease, Marijn Vis

Feb 25, 2019

Databases GRAPPA Prognosis psoriasis psoriatic arthritis Registries Arthritis Psoriatic Databases Factual Dermatology Humans Rheumatology

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Trajectory of radiographic change over a decade

Andrew Allard, Anna Antony, Gavin Shaddick, Deepak R Jadon, Charlotte Cavill, Graham Robinson, Eleanor Korendowych, Neil McHugh, William Tillett

Feb 01, 2019

Objectives: To describe the trajectory of radiographic progression among patients with PsA who transitioned from conventional synthetic DMARDs to anti-TNF-α inhibitors in routine care.

Methods: A retrospective sample of...

Anti-tumour necrosis factor (anti-TNF) Conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) psoriatic arthritis Radiographic progression

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Trajectory of radiographic change over a decade

Andrew Allard, Anna Antony, Gavin Shaddick, Deepak R Jadon, Charlotte Cavill, Graham Robinson, Eleanor Korendowych, Neil McHugh, William Tillett

Feb 01, 2019

Objectives: To describe the trajectory of radiographic progression among patients with PsA who transitioned from conventional synthetic DMARDs to anti-TNF-α inhibitors in routine care.

Methods: A retrospective sample of...

Anti-tumour necrosis factor (anti-TNF) Conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) psoriatic arthritis Radiographic progression