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Animals Autophagy Disease Models Animal Genetic Therapy Interferon-beta Lewy Body Disease Mice Mice Inbred C57BL Neurons Parkinson Disease Receptor Interferon alpha-beta Signal Transduction Transcriptome ALPHA-SYNUCLEIN

The importance of addressing food waste has gathered momentum and is being prioritised by many countries as it enables waste management to be moved up the waste hierarchy through preventing the generation of such waste and the...

Information Resources Management Social Sciences and Humanities Human Aspects of Technology

Heliconius Lepidoptera Pollen feeding Proteomics Saliva Animals Butterflies Feeding Behavior Hydrolysis Insect Proteins pollen Proteolysis Proteome Proteomics Saliva Salivary Proteins and Peptides

survey research measurement equivalence operations management

survey research measurement equivalence operations management

To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake...

NTS PBN anorexia aversion calcitonin receptor obesity Animals Body Weight Eating Energy Metabolism Female Male Mice Mice Inbred C57BL Mice Knockout Neurons Receptors Calcitonin Solitary Nucleus

Purpose: Advanced-stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating...

Adenocarcinoma Clear Cell Animals Cell Line Tumor Cell Proliferation Class I Phosphatidylinositol 3-Kinases DNA-Binding Proteins Female Gene Expression Regulation Neoplastic Heterografts Humans Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Morpholines Mutation Nuclear Proteins Ovarian Neoplasms Signal Transduction Transcription Factors

Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mm biopsy), which...

Biomarkers homogenization molecular profiling representative sampling tumor hetereogeneity tumor mutational burden tumor sampling tumor sequencing Biomarkers Tumor Biopsy High-Throughput Nucleotide Sequencing Humans Lung Neoplasms Mutation Tumor Burden Urinary Bladder Neoplasms

Microalgae are regarded as promising organisms to develop innovative concepts based on their photosynthetic capacity that offers more sustainable production than heterotrophic hosts. However, to realize their potential as green...

Chlamydomonas reinhardtii algal biotechnology modular cloning synthetic biology Biotechnology Chlamydomonas reinhardtii Gene Expression Genes Reporter Green Fluorescent Proteins Photosynthesis Plasmids Promoter Regions Genetic synthetic biology

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism...

T cell receptor TCR clonal maintenance TCR clonal replacement Anti-PD-1 Autopsy clear cell renal cell carcinoma human endogenous retrovirus multiregion Nivolumab CD8-Positive T-Lymphocytes Carcinoma Renal Cell Clinical Trials Phase II as Topic Drug Resistance Neoplasm endogenous retroviruses Gene Expression Profiling Genomics Humans Immune Checkpoint Inhibitors Kidney Neoplasms Nivolumab Prospective Studies Receptors Antigen T-Cell Sequence Analysis RNA Single-Cell Analysis Tumor Escape Tumor Microenvironment Exome Sequencing