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Assessment of cerebral autoregulation indices - a modelling perspective.
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Despina Aphroditi Lalou, Xiao Hu, Peter J Hutchinson, Peter Smielewski
Aug 07, 2020
Various methodologies to assess cerebral autoregulation (CA) have been developed, including model - based methods (e.g. autoregulation index, ARI), correlation coefficient - based methods (e.g. mean flow index, Mx), and...
Assessment of cerebral autoregulation indices – a modelling perspective
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Despina Aphroditi Lalou, Xiao Hu, Peter J. Hutchinson, Peter Smielewski
Jun 15, 2020
Abstract: Various methodologies to assess cerebral autoregulation (CA) have been developed, including model - based methods (e.g. autoregulation index, ARI), correlation coefficient - based methods (e.g. mean flow index, Mx)...
Assessment of cerebral autoregulation indices – a modelling perspective
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Despina Aphroditi Lalou, Xiao Hu, Peter J. Hutchinson, Peter Smielewski
Jun 15, 2021
Abstract: Various methodologies to assess cerebral autoregulation (CA) have been developed, including model - based methods (e.g. autoregulation index, ARI), correlation coefficient - based methods (e.g. mean flow index, Mx)...
Use of CSF infusion studies to unblock occluded hydrocephalus ventricular shunt catheters
Two patients with ventriculoperitoneal shunts presented with symptoms of raised intracranial pressure indicative of possible shunt malfunction. During investigation, to eliminate this possibility, cerebral spinal fluid infusion...
Are Slow Waves of Intracranial Pressure Suppressed by General Anaesthesia?
Despina Afroditi Lalou, Marek Czosnyka, Joseph Donnelly, Andrea Lavinio, John D Pickard, Matthew Garnett, Zofia Czosnyka
May 17, 2018
OBJECTIVES: Slow waves of intracranial pressure (ICP) are spontaneous oscillations with a frequency of 0.3-4 cycles/min. They are often associated with pathological conditions, following vasomotor activity in the cranial...
B-waves General anesthesia Hydrocephalus Intracranial Pressure Slow waves Adolescent Adult Aged Aged 80 and over Anesthesia General Anesthetics Intravenous Brain Injuries Traumatic Female Humans Hydrocephalus Hydrocephalus Normal Pressure Intracranial Pressure Male Middle Aged Monitoring Physiologic Young Adult
CSF Dynamics for Shunt Prognostication and Revision in Normal Pressure Hydrocephalus
Afroditi Despina Lalou, Marek Czosnyka, Michal M. Placek, Peter Smielewski, Eva Nabbanja, Zofia Czosnyka
Apr 16, 2021
Background: Despite the quantitative information derived from testing of the CSF circulation, there is still no consensus on what the best approach could be in defining criteria for shunting and predicting response to CSF...
Influence of general anaesthesia on slow waves of intracranial pressure.
Despina A Lalou, Marek Czosnyka, Joseph Donnelly, Andrea Lavinio, John D Pickard, Matthew Garnett, Zofia Czosnyka
Jun 17, 2016
B-waves Cerebrospinal fluid dynamics General anaesthesia Hydrocephalus Aged Aged 80 and over Anesthesia General Case-Control Studies Cerebrovascular Circulation Cognition Disorders Cohort Studies Consciousness Female Humans Hydrocephalus Normal Pressure Intracranial Pressure Male Perfusion Periodicity
Coupling of CSF and sagittal sinus pressure in adult patients with pseudotumour cerebri
Afroditi-Despina Lalou, Marek Czosnyka, Zofia H. Czosnyka, Deepa Krishnakumar, John D. Pickard, Nick J. Higgins
Dec 11, 2020
Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome
Afroditi-Despina Lalou, James S. McTaggart, Zofia H. Czosnyka, Matthew R Garnett, Deepa Krishnakumar, Marek Czosnyka
Jun 06, 2020
Coupling of CSF and sagittal sinus pressure in adult patients with pseudotumour cerebri.
Afroditi-Despina Lalou, Marek Czosnyka, Zofia H Czosnyka, Deepa Krishnakumar, John D Pickard, Nick J Higgins
Oct 10, 2019
OBJECTIVE: Pseudotumour cerebri syndrome (PTCS including idiopathic intracranial hypertension) is characterised by the symptoms and signs of raised cerebrospinal fluid pressure (CSFp) in the absence of ventricular dilatation or...
Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome.
Afroditi-Despina Lalou, James S McTaggart, Zofia H Czosnyka, Matthew R Garnett, Deepa Krishnakumar, Marek Czosnyka
Jun 26, 2019
PURPOSE: There is a growing body of evidence highlighting the importance of comprehensive intracranial pressure (ICP) values in pseudotumor cerebri syndrome (PTCS). Due to the highly dynamic nature of ICP, several methods of ICP...
Coupling of CSF and sagittal sinus pressure in adult patients with pseudotumour cerebri
Afroditi-Despina Lalou, Marek Czosnyka, Zofia H. Czosnyka, Deepa Krishnakumar, John D. Pickard, Nick J. Higgins
Jun 06, 2020
Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome
Afroditi-Despina Lalou, James S. McTaggart, Zofia H. Czosnyka, Matthew R Garnett, Deepa Krishnakumar, Marek Czosnyka
Jul 18, 2020
CSF Dynamics for Shunt Prognostication and Revision in Normal Pressure Hydrocephalus.
Afroditi Despina Lalou, Marek Czosnyka, Michal M Placek, Peter Smielewski, Eva Nabbanja, Zofia Czosnyka
Jul 12, 2021
BACKGROUND: Despite the quantitative information derived from testing of the CSF circulation, there is still no consensus on what the best approach could be in defining criteria for shunting and predicting response to CSF...
Ventriculo-peritoneal shunting is a safe and effective treatment for idiopathic intracranial hypertension.
Anna Bjornson, Ian Tapply, Eva Nabbanja, Afrodite-Despina Lalou, Marek Czosnyka, Zofia Czosnyka, Brinda Muthusamy, Matthew Garnett
Mar 11, 2019
PURPOSE: To determine the outcome of ventriculo-peritoneal shunts as a treatment for idiopathic intracranial hypertension (IIH) Materials and Methods: Retrospective case series of 28 patients with IIH and evidence of raised...
Idiopathic intracranial hypertension Orbis sigma valve Ventriculo-peritoneal shunt Adolescent Adult Child Databases Factual Female Headache Disorders Humans Male Middle Aged Postoperative care Postoperative Complications Pseudotumor Cerebri Reoperation Retrospective Studies Spinal Puncture Treatment Outcome Ventriculoperitoneal Shunt vision disorders Visual Acuity Young Adult
Shunt infusion studies
Afroditi-Despina Lalou, Marek Czosnyka, Matthew R. Garnett, Eva Nabbanja, Gianpaolo Petrella, Peter J. Hutchinson, John D. Pickard, Zofia Czosnyka
Feb 19, 2021
Value of computerized shunt infusion study in assessment of pediatric hydrocephalus shunt function-a two center cross-sectional study.
Sandra Fernandes Dias, Afroditi-Despina Lalou, Regine Spang, Karin Haas-Lude, Matthew Garnett, Helen Fernandez, Marek Czosnyka, Martin U Schuhmann, Zofia Czosnyka
Jul 02, 2019
BACKGROUND: Hydrocephalus shunt malfunction can-also in children-occur insidiously without clear symptoms of raised intracranial pressure (ICP) or changes in ventricular size, imposing a diagnostic challenge. Computerized shunt...
Shunt infusion studies
Afroditi-Despina Lalou, Marek Czosnyka, Matthew R. Garnett, Eva Nabbanja, Gianpaolo Petrella, Peter J. Hutchinson, John D. Pickard, Zofia Czosnyka
Jun 06, 2020
Shunt infusion studies
Afroditi-Despina Lalou, Marek Czosnyka, Matthew R Garnett, Eva Nabbanja, Gianpaolo Petrella, Peter J Hutchinson, John D Pickard, Zofia Czosnyka
Feb 03, 2020
Cerebrospinal fluid diversion Hydrocephalus Idiopathic intracranial hypertension Infusion studies Pseudotumour cerebri Shunt testing in vivo Shunts Adolescent Adult Age Factors Aged Aged 80 and over Cerebrospinal Fluid Shunts Child Child Preschool Female Humans Hydrocephalus Infant Intracranial Pressure Male Middle Aged Pseudotumor Cerebri Retrospective Studies State Medicine Young Adult
Validation of Davson's equation in patients suffering from idiopathic normal pressure hydrocephalus.
Afroditi-Despina Lalou, Virginia Levrini, Matthew Garnett, Eva Nabbanja, Dong-Joo Kim, Laurent Gergele, Anna Bjornson, Zofia Czosnyka, Marek Czosnyka
May 29, 2018
INTRODUCTION: The so-called Davson's equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (If) and sagittal sinus pressure (PSS) There is a...
Cerebral autoregulation, cerebrospinal fluid outflow resistance, and outcome following cerebrospinal fluid diversion in normal pressure hydrocephalus.
Afroditi Despina Lalou, Marek Czosnyka, Joseph Donnelly, John D Pickard, FMedSci, Eva Nabbanja, Nicole C Keong, Matthew Garnett, Zofia H Czosnyka
Jun 12, 2018
OBJECTIVE: Normal pressure hydrocephalus is not simply the result of a disturbance in CSF circulation, but often includes cardiovascular comorbidity and abnormalities within the cerebral mantle. In this study, the authors have...
ABP = arterial blood pressure CBF = cerebral blood flow CPP = cerebral perfusion pressure ETV = endoscopic third ventriculostomy ICP = intracranial pressure MAP = mean ABP NPH = normal pressure hydrocephalus PRx PRx = pressure reactivity index RAP = cerebrospinal compensatory reserve index Rout = resistance to CSF outflow autoregulation cerebrospinal fluid fAMP = fundamental amplitude of ICP infusion test Normal pressure hydrocephalus pressure reactivity index Resistance to CSF outflow Aged Aged 80 and over blood pressure Cerebrovascular Circulation Cohort Studies Female Homeostasis Humans Hydrocephalus Normal Pressure Male Treatment Outcome Ventriculoperitoneal Shunt
Printable graphene BioFETs for DNA quantification in Lab-on-PCB microsystems
Lab-on-Chip is a technology that aims to transform the Point-of-Care (PoC) diagnostics field; nonetheless a commercial production compatible technology isyet to be established. Lab-on-Printed Circuit Board (Lab-on-PCB) is...
Intracranial pressure, its components and cerebrospinal fluid pressure-volume compensation.
Clinical measurement of intracranial pressure (ICP) is often performed to aid diagnosis of hydrocephalus. This review discusses analysis of ICP and its components' for the investigation of cerebrospinal fluid (CSF) dynamics. The...
Electrochemical Sensors Based on Metal Nanoparticles with Biocatalytic Activity
Biosensors have attracted a great deal of attention, as they allow for the translation of the standard laboratory-based methods into small, portable devices. The field of biosensors has been growing, introducing innovations...
An electrochemical device to control sample pH locally in Lab-on-PCB devices
During the recent pandemic outbreak, Lab-on-Chip devices did not manage to fully reach their potential in rapid diagnosis of pathogens, mainly due to the lack of cost-effective LoC solutions integrated with all required sample...
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