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Results: 179
A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation.
Tom Dendooven, Dhriti Sinha, Alzbeta Roeselová, Todd A Cameron, Nicholas R De Lay, Ben F Luisi, Katarzyna J Bandyra
May 28, 2021
Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans. Paradoxically, Escherichia coli PNPase can act not only as an...
Hfq RNA chaperone cryoEM Gene Silencing polynucleotide phosphorylase Ribonuclease ribonucleoprotein complex riboregulation small regulatory RNA Catalytic Domain Endoribonucleases Escherichia coli Escherichia coli Proteins Exoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Chaperones Polyribonucleotide Nucleotidyltransferase RNA Stability RNA Bacterial RNA Small Untranslated
Fabrication of TiO2 microspikes for highly efficient intracellular delivery by pulse laser-assisted photoporation.
The introduction of foreign cargo into living cells with high delivery efficiency and cell viability is a challenge in cell biology and biomedical research. Here, we demonstrate a nanosecond pulse laser-activated photoporation...
New models to study vascular mural cell embryonic origin
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases....
Englishization in offshore call centers
The spread and use of English as the lingua franca of international business (IB)-"corporate Englishization"-has received increasing scholarly attention in recent years but the focus has mostly been on the communication...
Aortic “Disease-in-a-Dish”
Thoracic aortic diseases, whether sporadic or due to a genetic disorder such as Marfan syndrome, lack effective medical therapies, with limited translation of treatments that are highly successful in mouse models into the...
Englishization in offshore call centers
The spread and use of English as the lingua franca of international business (IB)-"corporate Englishization"-has received increasing scholarly attention in recent years but the focus has mostly been on the communication...
Embryonic origins of human vascular smooth muscle cells
Vascular smooth muscle cells (SMCs) arise from multiple origins during development, raising the possibility that differences in embryological origins between SMCs could contribute to site-specific localization of vascular...
Finite element analysis of the microstructure of AlN-TiN composites
Finite element modelling (FEM) is performed on AlN-TiN composites. The structure-property relationships are studied for 5 and 10vol.% TiN composites in view of thermal and thermo-mechanical properties. Thermal stresses are...
ROP Defense Using Trie Graph for System Security
Most Intrusion Detection Systems (IDS) / Intrusion Prevention Systems (IPS) cannot defend the attacks from a Return Oriented Program (ROP) which applies code reusing and exploiting techniques without the need for code injection....
Published by: IGI Global Scientific Publishing
Self-Aware Contextual Behavior Analysis for Service Quality Assurance Over Social Networks
Social media allows people to share their ideologue through an efficient channel of communication. The social dialogues carry sentiment in expression regarding a particular social profile, trend, or topic. In our research, we...
Published by: IGI Global Scientific Publishing
Investigating Host and Parasitic Plant Interaction by Tissue-Specific Gene Analyses on Tomato and Cuscuta campestris Interface at Three Haustorial Developmental Stages.
Parasitic weeds cause billions of dollars in agricultural losses each year worldwide. Cuscuta campestris (C. campestris), one of the most widespread and destructive parasitic plants in the United States, severely reduces yield...
Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals.
Balakrishnan Chakrapani Narmada, Yeek Teck Goh, Huan Li, Sanjay Sinha, Hanry Yu, Christine Cheung
Feb 07, 2019
Atherosclerosis underlies many cardiovascular and cerebrovascular diseases. Nutraceuticals are emerging as a therapeutic moiety for restoring vascular health. Unlike small-molecule drugs, the complexity of ingredients in...
Coculture Endothelial Cells Hepatocytes Human pluripotent stem cells metabolism Nutraceutical testing Culture Media Conditioned Dietary Supplements endothelial progenitor cells Genistein Hepatocytes Human Embryonic Stem Cells Humans Inflammation Interleukin-1beta Liver Metabolome Pluripotent Stem Cells Protective Agents Quercetin
Cell cycle regulators control mesoderm specification in human pluripotent stem cells.
Loukia Yiangou, Rodrigo A Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier
Sep 25, 2019
RB transcriptional corepressor 1 (RB1) Cell Cycle cyclin-dependent kinase (CDK) DIFFERENTIATION embryo development Gene Expression Mesoderm Pluripotency signaling Stem Cells tissue regeneration Cell Cycle Cell Differentiation Cell Lineage Cyclin-Dependent Kinases Human Embryonic Stem Cells Humans MAP Kinase Signaling System Mesoderm Protein Kinase Inhibitors Retinoblastoma Binding Proteins Ubiquitin-Protein Ligases
A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.
Samal Zhussupbekova, Rohit Sinha, Paula Kuo, Paul F Lambert, Ian H Frazer, Zewen K Tuong
Sep 02, 2019
A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium. Here we...
E7 HPV16 Hyperplasia Keratins Animals Cell Differentiation Cytoskeleton Disease Models Animal Gene Expression Human papillomavirus 16 Humans Keratin-14 Keratins Keratosis Mice Mice Inbred C57BL Mice Transgenic Microscopy Confocal Papillomavirus E7 Proteins Promoter Regions Genetic Skin Transplantation Homologous
Finite element analysis of the microstructure of AlN-TiN composites
Finite element modelling (FEM) is performed on AlN-TiN composites. The structure-property relationships are studied for 5 and 10vol.% TiN composites in view of thermal and thermo-mechanical properties. Thermal stresses are...
Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.
BACKGROUND: Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced...
Adoption of ICT enabled Agricultural Extension Services through Perceived Economic Wellbeing
This article investigates the technology acceptance factors in the context of information communication technology enabled agricultural extension services. Behavioral intention has always been a consequence of the technology...
Published by: IGI Global Scientific Publishing
Wearable Technology and Women Empowerment in the Technology Industry
The extant literature has significantly contributed towards the body of knowledge on wearable technology by exploring its potential for enhancing the well-being of consumers. Another strand of literature focuses on the...
Published by: IGI Global Scientific Publishing
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
Evolving Host Socio-Demographical Determinants Towards Himalayan Handicraft Industry
Himachal Pradesh is widely known for its beauty, culture and heritage. The handicrafts of this region maintain cultural integrity among themselves and show it to the rest of the world. This paper aims to investigate the dynamics...
Published by: IGI Global Scientific Publishing
Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.
Matthew Ackers-Johnson, Amarnath Talasila, Andrew P Sage, Xiaochun Long, Ilze Bot, Nicholas W Morrell, Martin R Bennett, Joseph M Miano, Sanjay Sinha
Mar 16, 2015
Atherosclerosis Inflammation myocardin smooth muscle Animals Apolipoproteins E Atherosclerosis Carotid Artery Injuries Cell Adhesion Cell Adhesion Molecules Cells Cultured Chemokines Chemotaxis Cytokines Disease Models Animal Genotype Human Umbilical Vein Endothelial Cells Humans Inflammation Lipid Metabolism MACROPHAGES Male Mice 129 Strain Mice Inbred C57BL Mice Knockout Monocytes Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Nuclear Proteins Phenotype RNA Interference Rats Wistar Time Factors Trans-Activators Transfection
The Role of Nutrition in Degenerative Cervical Myelopathy
Celine I Partha Sarathi, Oliver D Mowforth, Amil Sinha, Faheem Bhatti, Aniqah Bhatti, Melika Akhbari, Shahzaib Ahmed, Ben Davies
Oct 08, 2021
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