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Results: 15562
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
Diana C Rodriguez Camargo, Sean Chia, Joseph Menzies, Benedetta Mannini, Georg Meisl, Martin Lundqvist, Christin Pohl, Katja Bernfur, Veronica Lattanzi, Johnny Habchi, Samuel IA Cohen, Tuomas PJ Knowles, Michele Vendruscolo, Sara Linse
Nov 22, 2021
The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is...
Reprogramming of the wheat transcriptome in response to infection with Claviceps purpurea, the causal agent of ergot.
Eleni Tente, Nelzo Ereful, Anyela Camargo Rodriguez, Paul Grant, Donal M O'Sullivan, Lesley A Boyd, Anna Gordon
Aug 11, 2021
BACKGROUND: Ergot, caused by the fungal pathogen Claviceps purpurea, infects the female flowers of a range of cereal crops, including wheat. To understand the interaction between C. purpurea and hexaploid wheat we undertook an...
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel IA Cohen, Georg Meisl, Johnny Habchi, Tuomas PJ Knowles, Michele Vendruscolo, Sara Linse
Jan 07, 2022
The self-assembly of the protein tau into neurofibrillary tangles is one of the hallmarks of Alzheimer's disease and related tauopathies. Still, the molecular mechanism of tau aggregation is largely unknown. This problem may be...
Reprogramming of the wheat transcriptome in response to infection with Claviceps purpurea, the causal agent of ergot
Eleni Tente, Nelzo Ereful, Anyela Camargo Rodriguez, Paul Grant, Donal M. O’Sullivan, Lesley A. Boyd, Anna Gordon
Jul 02, 2021
Abstract: Background: Ergot, caused by the fungal pathogen Claviceps purpurea, infects the female flowers of a range of cereal crops, including wheat. To understand the interaction between C. purpurea and hexaploid wheat we...
Multilingual Britain – Towards a coherent policy framework for children with EAL
Diana Sutton
Dec 06, 2017
In this article, Diana Sutton, Director of the Bell Foundation, explores the current policy and practice framework for supporting children with English as an Additional Language in the UK and how the available research evidence...
Published by: MEITS
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
C. elegans expressing D76N β2-microglobulin
Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A Partridge, Cristina Soria, P Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A Aprile, Irene Zorzoli, Elia Di Schiavi, David A Lomas, Vittorio Bellotti, David B Sattelle, Sofia Giorgetti
Mar 02, 2020
The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural...
Injectable Thermosensitive Nanocomposites Based on Poly(N-vinylcaprolactam) and Silica Particles for Localized Release of Hydrophilic and Hydrophobic Drugs.
The systemic delivery of drugs employed by conventional methods has shown to be less effective than a localized delivery system. Many drugs have the effectiveness reduced by fast clearance, increasing the amount required for an...
Investigating the Effect of the wee-1.3 and pam-1 Mutations on Meiosis in C. elegans
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
C. elegans expressing D76N β2-microglobulin
Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A Partridge, Cristina Soria, P Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A Aprile, Irene Zorzoli, Elia Di Schiavi, David A Lomas, Vittorio Bellotti, David B Sattelle, Sofia Giorgetti
Jan 29, 2020
The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural...
Search for the doubly heavy baryons Ω<inf>bc</inf><sup>0</sup>and Ξ<inf>bc</inf><sup>0</sup>decaying to Λ<inf>c</inf><sup>+</sup>π- And Ξ<inf>c</inf><sup>+</sup>π- And c
C Nguyen-Mau, R Aaij, C Abellán Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, G Alkhazov, P Alvarez Cartelle, S Amato, Y Amhis, L An, L Anderlini, A Andreianov, M Andreotti, F Archilli, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, M Bachmayer, JJ Back, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista Leite, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, JM Basels, G Bassi, B Batsukh, A Battig, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, V Belavin, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, I Bezshyiko, S Bhasin, J Bhom, L Bian, MS Bieker, S Bifani, P Billoir, M Birch, FCR Bishop, A Bitadze, A Bizzeti, M Bj rn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, JA Boelhauve, O Boente Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, SA Bouchiba, TJV Bowcock, A Boyer, C Bozzi, MJ Bradley
Aug 31, 2021
The first search for the doubly heavy $\it{\Omega}_{bc}^{\rm0}$ baryon and a
search for $\it{\Xi}_{bc}^{\rm0}$ baryon are performed using $pp$ collision
data collected via the LHCb experiment from 2016 to 2018 at a...
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. elegans Aging.
Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Jul 01, 2019
In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study...
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
Runaway Jury
The no impeachment rule bars the admission into evidence of juror testimony regarding jury deliberations in proceedings questioning the validity of a verdict. In Pena-Rodriguez v. Colorado (2017), the U.S. Supreme Court created...
no impeachment rule Sixth Amendment impartial jury racial bias rules of evidence jury decision-making Criminology and Criminal Justice law
Published by: Digital Commons @ Texas A&M University-San Antonio
Runaway Jury
The no impeachment rule bars the admission into evidence of juror testimony regarding jury deliberations in proceedings questioning the validity of a verdict. In Pena-Rodriguez v. Colorado (2017), the U.S. Supreme Court created...
no impeachment rule Sixth Amendment impartial jury racial bias rules of evidence jury decision-making Criminology and Criminal Justice law
Published by: Digital Commons @ Texas A&M University-San Antonio
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Tillman Award Given to Biology Major at Commencement
Winthrop University
Jan 01, 0001
Diana Lynn Soteropoulos received the Tillman Award Dec. 15 during fall commencement. Soteropoulos of Williamsburg, Va., is a biology major.
Published by: Winthrop University
Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage.
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and...
Precision measurement of the Lambda(+)(c) baryon mass
B Aubert, R Barate, D Boutigny, F Couderc, Y Karyotakis, JP Lees, V Poireau, V Tisserand, A Zghiche, E Grauges, A Palano, M Pappagallo, A Pompili, JC Chen, ND Qi, G Rong, P Wang, YS Zhu, G Eigen, I Ofte, B Stugu, GS Abrams, M Battaglia, AB Breon, DN Brown, J Button-Shafer, RN Cahn, E Charles, CT Day, MS Gill, AV Gritsan, Y Groysman, RG Jacobsen, RW Kadel, J Kadyk, LT Kerth, YG Kolomensky, G Kukartsev, G Lynch, LM Mir, PJ Oddone, TJ Orimoto, M Pripstein, NA Roe, MT Ronan, WA Wenzel, M Barrett, KE Ford, TJ Harrison, AJ Hart, CM Hawkes, SE Morgan, AT Watson, M Fritsch, K Goetzen, T Held, H Koch, B Lewandowski, M Pelizaeus, K Peters, T Schroeder, M Steinke, JT Boyd, JP Burke, N Chevalier, WN Cottingham, T Cuhadar-Donszelmann, BG Fulsom, C Hearty, NS Knecht, TS Mattison, JA McKenna, A Khan, P Kyberd, M Saleem, L Teodorescu, AE Blinov, VE Blinov, AD Bukin, VP Druzhinin, VB Golubev, EA Kravchenko, AP Onuchin, SI Serednyakov, YI Skovpen, EP Solodov, AN Yushkov, D Best, M Bondioli, M Bruinsma, M Chao, S Curry, I Eschrich, D Kirkby, AJ Lankford, P Lund, M Mandelkern, RK Mommsen, W Roethel, DP Stoker, C Buchanan, BL Hartfiel, AJR Weinstein, SD Foulkes, JW Gary, O Long, BC Shen, K Wang, L Zhang, D Del Re, HK Hadavand, EJ Hill, DB MacFarlane, HP Paar, S Rahatlou, V Sharma, JW Berryhill, C Campagnari, A Cunha, B Dahmes, TM Hong, MA Mazur, JD Richman, W Verkerke, TW Beck, AM Eisner, CJ Flacco, CA Heusch, J Kroseberg, WS Lockman, G Nesom, T Schalk, BA Schumm, A Seiden, P Spradlin, DC Williams, MG Wilson, J Albert, E Chen, GP Dubois-Felsmann, A Dvoretskii, DG Hitlin, I Narsky, T Piatenko, FC Porter, A Ryd, A Samuel, R Andreassen, S Jayatilleke, G Mancinelli, BT Meadows, MD Sokoloff, F Blanc, P Bloom, S Chen, WT Ford, JF Hirschauer, A Kreisel, U Nauenberg, A Olivas, P Rankin, WO Ruddick, JG Smith, KA Ulmer, SR Wagner, J Zhang, A Chen, EA Eckhart, A Soffer, WH Toki, RJ Wilson, Q Zeng, D Altenburg, E Feltresi, A Hauke, B Spaan, T Brandt, J Brose, M Dickopp, V Klose, HM Lacker, R Nogowski, S Otto, A Petzold, G Schott, J Schubert, KR Schubert, R Schwierz, JE Sundermann, D Bernard, GR Bonneaud, P Grenier, S Schrenk, C Thiebaux, G Vasileiadis, M Verderi, DJ Bard, PJ Clark, W Gradl, F Muheim, S Playfer, Y Xie, M Andreotti, V Azzolini, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Luppi, M Negrini, L Piemontese, F Anulli, R Baldini-Ferroli, A Calcaterra, R De Sangro, G Finocchiaro, P Patteri, IM Peruzzi, M Piccolo, A Zallo, A Buzzo, R Capra, R Contri, M Lo Vetere, M Macri, MR Monge, S Passaggio, C Patrignani, E Robutti, A Santroni, S Tosi, G Brandenburg, KS Chaisanguanthum, M Morii, E Won, J Wu, RS Dubitzky, U Langenegger, J Marks, S Schenk, U Uwer, W Bhimji, DA Bowerman, PD Dauncey, U Egede, RL Flack, JR Gaillard, GW Morton, JA Nash, MB Nikolich, GP Taylor, WP Vazquez, MJ Charles, WF Mader, U Mallik, AK Mohapatra, J Cochran, HB Crawley, V Eyges, WT Meyer, S Prell, EI Rosenberg, AE Rubin, J Yi, N Arnaud, M Davier, X Giroux, G Grosdidier, A Hocker, F Le Diberder, V Lepeltier, AM Lutz, A Oyanguren, TC Petersen, M Pierini, S Plaszczynski, S Rodier, P Roudeau, MH Schune, A Stocchi, G Wormser, CH Cheng, DJ Lange, MC Simani, DM Wright, AJ Bevan, CA Chavez, IJ Forster, JR Fry, E Gabathuler, R Gamet, KA George, DE Hutchcroft, RJ Parry, DJ Payne, KC Schofield, C Touramanis, CM Cormack, F Di Lodovico, W Menges, R Sacco, CL Brown, G Cowan, HU Flaecher, MG Green, DA Hopkins, PS Jackson, TR McMahon, S Ricciardi, F Salvatore, D Brown, CL Davis, J Allison, NR Barlow, RJ Barlow, CL Edgar, MC Hodgkinson, MP Kelly, GD Lafferty, MT Naisbit, JC Williams, C Chen, WD Hulsbergen, A Jawahery, D Kovalskyi, CK Lae, DA Roberts, G Simi, G Blaylock, C Dallapiccola, SS Hertzbach, R Kofler, VB Koptchev, X Li, TB Moore, S Saremi, H Staengle, S Willocq, R Cowan, K Koeneke, G Sciolla, SJ Sekula, M Spitznagel, F Taylor, RK Yamamoto, H Kim, PM Patel, SH Robertson, A Lazzaro, V Lombardo, F Palombo, JM Bauer, L Cremaldi, V Eschenburg, R Godang, R Kroeger, J Reidy, DA Sanders, DJ Summers, HW Zhao, S Brunet, D Cote, P Taras, B Viaud, H Nicholson, N Cavallo, G De Nardo, F Fabozzi, C Gatto, L Lista, D Monorchio, P Paolucci, D Piccolo, C Sciacca, M Baak, H Bulten, G Raven, HL Snoek, L Wilden, CP Jessop, JM LoSecco, T Allmendinger, G Benelli, KK Gan, K Honscheid, D Hufnagel, PD Jackson, H Kagan, R Kass, T Pulliam, AM Rahimi, R Ter-Antonyan, QK Wong, J Brau, R Frey, O Igonkina, M Lu, CT Potter, NB Sinev, D Strom, J Strube, E Torrence, F Galeazzi, M Margoni, M Morandin, M Posocco, M Rotondo, F Simonetto, R Stroili, C Voci, M Benayoun, H Briand, J Chauveau, P David, L Del Buono, C de la Vaissiere, O Hamon, MJJ John, P Leruste, J Malcles, J Ocariz, L Roos, G Therin, PK Behera, L Gladney, QH Guo, J Panetta, M Biasini, R Covarelli, S Pacetti, M Pioppi, C Angelini, G Batignani, S Bettarini, F Bucci, G Calderini, M Carpinelli, R Cenci, F Forti, MA Giorgi, A Lusiani, G Marchiori, M Morganti, N Neri, E Paoloni, M Rama, G Rizzo, J Walsh, M Haire, D Judd, DE Wagoner, J Biesiada, N Danielson, P Elmer, YP Lau, C Lu, J Olsen, AJS Smith, AV Telnov, F Bellini, G Cavoto, A D'Orazio, E Di Marco, R Faccini, F Ferrarotto, F Ferroni, M Gaspero, L Li Gioi, MA Mazzoni, S Morganti, G Piredda, F Polci, FS Tehrani, C Voena, H Schroder, G Wagner, R Waldi, T Adye, N De Groot, B Franek, GP Gopal, EO Olaiya, FF Wilson, R Aleksan, S Emery, A Gaidot, SF Ganzhur, PF Giraud, G Graziani, GH de Monchenault, W Kozanecki, M Legendre, GW London, B Mayer, G Vasseur, C Yeche, M Zito, MV Purohit, AW Weidemann, JR Wilson, FX Yumiceva, T Abe, MT Allen, D Aston, N Bakel, R Bartoldus, N Berger, AM Boyarski, OL Buchmueller, R Claus, JP Coleman, MR Convery, M Cristinziani, JC Dingfelder, D Dong, J Dorfan, D Dujmic, W Dunwoodie, S Fan, RC Field, T Glanzman, SJ Gowdy, T Hadig, V Halyo, C Hast, T Hryn'ova, WR Innes, MH Kelsey, P Kim, ML Kocian, DWGS Leith, J Libby, S Luitz, V Luth, HL Lynch, H Marsiske, R Messner, DR Muller, CP O'Grady, VE Ozcan, A Perazzo, M Perl, BN Ratcliff, A Roodman, AA Salnikov, RH Schindler, J Schwiening, A Snyder, J Stelzer, D Su, MK Sullivan, K Suzuki, S Swain, JM Thompson, J Va'Vra, M Weaver, WJ Wisniewski, M Wittgen, DH Wright, AK Yarritu, K Yi, CC Young, PR Burchat, AJ Edwards, SA Majewski, BA Petersen, C Roat, M Ahmed, S Ahmed, MS Alam, JA Ernst, MA Saeed, FR Wappler, SB Zain, W Bugg, M Krishnamurthy, SM Spanier, R Eckmann, JL Ritchie, A Satpathy, RF Schwitters, JM Izen, I Kitayama, XC Lou, S Ye, F Bianchi, M Bona, F Gallo, D Gamba, M Bomben, L Bosisio, C Cartaro, F Cossutti, G Della Ricca, S Dittongo, S Grancagnolo, L Lanceri, L Vitale, F Martinez-Vidal, RS Panvini, S Banerjee, B Bhuyan, CM Brown, D Fortin, K Hamano, R Kowalewski, JM Roney, RJ Sobie, JJ Back, PF Harrison, TE Latham, GB Mohanty, HR Band, X Chen, B Cheng, S Dasu, M Datta, AM Eichenbaum, KT Flood, M Graham, JJ Hollar, JR Johnson, PE Kutter, H Li, R Liu, B Mellado, A Mihalyi, Y Pan, R Prepost, P Tan, JH von Wimmersperg-Toeller, SL Wu, Z Yu, H Neal, BaBar Collaboration
Jul 28, 2021
A precision measurement of the $B_{c}^{+}$ meson mass is performed using
proton-proton collision data collected with the LHCb experiment at
centre-of-mass energies of $7, 8$ and $13$ TeV, corresponding to a total
integrated...
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