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Results: 22
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray.
Elisabeth S Gruber, Georg Oberhuber, Dietmar Pils, Theresa Stork, Katharina Sinn, Sylvia Gruber, Robert Nica, Dan Kolmer, Suzanne D Turner, Michaela Schlederer, Joachim Widder, Wolfgang Doerr, Béla Teleky, Lukas Kenner
May 11, 2020
BACKGROUND: T cell density in colorectal cancer (CRC) has proven to be of high prognostic importance. Here, we evaluated the influence of a hyperfractionated preoperative short-term radiation protocol (25 Gy) on immune cell...
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray
Elisabeth S. Gruber, Georg Oberhuber, Dietmar Pils, Theresa Stork, Katharina Sinn, Sylvia Gruber, Robert Nica, Dan Kolmer, Suzanne D. Turner, Michaela Schlederer, Joachim Widder, Wolfgang Doerr, Béla Teleky, Lukas Kenner
Mar 01, 2020
Background: T cell density in colorectal cancer (CRC) has proven to be of high prognostic importance. Here, we evaluated the influence of a hyperfractionated preoperative short-term radiation protocol (25 Gy) on immune cell...
Product diversity linked to substrate usage in chain elongation by mixed-culture fermentation
Marta Coma, Ramiro Vilchez-Vargas, Hugo Roume, Ruy Jauregui, Dietmar H. Pieper, Korneel Rabaey
Jun 21, 2016
Acetate and ethanol can be converted to caproic acid by microorganisms through reverse β-oxidation. There is limited insight into the versatility of chain elongation in view of different starting substrates, including even- and...
A revisited Johnson-Mehl-Avrami-Kolmogorov model and the evolution of grain-size distributions in steel
The classical Johnson–Mehl–Avrami–Kolmogorov approach for nucleation and growth models of diffusive phase transitions is revisited and applied to model the growth of ferrite in multiphase steels. For the prediction of mechanical...
A revisited Johnson-Mehl-Avrami-Kolmogorov model and the evolution of grain-size distributions in steel
The classical Johnson–Mehl–Avrami–Kolmogorov approach for nucleation and growth models of diffusive phase transitions is revisited and applied to model the growth of ferrite in multiphase steels. For the prediction of mechanical...
Kinetic properties and small-molecule inhibition of human myosin-6.
Sarah M Heissler, Jayashankar Selvadurai, Lisa M Bond, Roman Fedorov, John Kendrick-Jones, Folma Buss, Dietmar J Manstein
Aug 14, 2020
Myosin-6 is an actin-based motor protein that moves its cargo towards the minus-end of actin filaments. Mutations in the gene encoding the myosin-6 heavy chain and changes in the cellular abundance of the protein have been...
Actins Amino-Acid N-Acetyltransferase Animals Gene Knockdown Techniques HeLa Cells Humans In Vitro Techniques Kinetics Models Biological Models Molecular Molecular Motor Proteins Mutagenesis Site-Directed Myosin Heavy Chains Phenols Protein Interaction Domains and Motifs RNA Small Interfering Rabbits Recombinant Fusion Proteins
Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.
Hemma Brandstaetter, Chieko Kishi-Itakura, David A Tumbarello, Dietmar J Manstein, Folma Buss
Feb 10, 2015
BafA1 bafilomycin A1 EGF epidermal growth factor EGFR epidermal growth factor receptor EM electron microscopy GFP green fluorescent protein KD knockdown LAMP1 lysosomal-associated membrane protein 1 LC3 microtubule-associated protein 1 light chain 3 MVB multivesicular body MYO1C myosin IC PB phosphate buffer PCIP pentachloropseudilin PtdIns(4 5)P2 phosphatidylinositol 4 5-bisphosphate RFP red fluorescent protein RPE retinal pigment epithelium Autophagy Cholesterol Electron microscopy lipid raft lysosome MYO1C Autophagy Cell Line Cell Movement Endocytosis Endosomes Humans Lysosomes Membrane Fusion Membrane Microdomains Myosin Type I Myosins Phagosomes Protein Transport
Product diversity linked to substrate usage in chain elongation by mixed-culture fermentation
Marta Coma, Ramiro Vilchez-Vargas, Hugo Roume, Ruy Jauregui, Dietmar H. Pieper, Korneel Rabaey
Jun 21, 2016
Acetate and ethanol can be converted to caproic acid by microorganisms through reverse β-oxidation. There is limited insight into the versatility of chain elongation in view of different starting substrates, including even- and...
Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model
Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux, Alexander Keller, Cornelius Miething, Marie Follo, Dietmar Pfeifer, Khalid Shoumariyeh, Claudia Lengerke, Irene Gonzalez-Menendez, Falko Fend, Robert Zeiser, Suzanne D. Turner, Leticia Quintanilla-Martinez, Melanie Boerries, Justus Duyster, Anna L. Illert
Nov 24, 2020
University students with attention deficit hyperactivity disorder (ADHD)
Jane A Sedgwick-Müller, Ulrich Müller-Sedgwick, Marios Adamou, Marco Catani, Rebecca Champ, Gísli Gudjónsson, Dietmar Hank, Mark Pitts, Susan Young, Philip Asherson
Apr 22, 2022
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is associated with poor educational outcomes that can have long-term negative effects on the mental health, wellbeing, and socio-economic outcomes of university...
Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model.
Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux, Alexander Keller, Cornelius Miething, Marie Follo, Dietmar Pfeifer, Khalid Shoumariyeh, Claudia Lengerke, Irene Gonzalez-Menendez, Falko Fend, Robert Zeiser, Suzanne D Turner, Leticia Quintanilla-Martinez, Melanie Boerries, Justus Duyster, Anna L Illert
Mar 17, 2021
4D perfusion CT of prostate cancer for image-guided radiotherapy planning
Lucian Beer, Stephan H Polanec, Pascal AT Baltzer, Georg Schatzl, Dietmar Georg, Christian Schestak, Anja Dutschke, Harald Herrmann, Peter Mazal, Alexander K Brendel, Shahrokh F Shariat, Helmut Ringl, Thomas H Helbich, Paul Apfaltrer
Feb 03, 2020
PURPOSE: Advanced forms of prostate cancer (PCa) radiotherapy with either external beam therapy or brachytherapy delivery techniques aim for a focal boost and thus require accurate lesion localization and lesion segmentation for...
Aged Biopsy Large-Core Needle Contrast Media Diffusion Magnetic Resonance Imaging Feasibility Studies Four-Dimensional Computed Tomography Humans Image-guided biopsy Male Middle Aged Neoplasm Grading Perfusion Imaging Proof of Concept Study Prospective Studies Prostate Prostatic Neoplasms Radiation Dosage Radiotherapy Planning Computer-Assisted Radiotherapy Image-Guided
Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
Krishna Chinthalapudi, Manuel H Taft, René Martin, Sarah M Heissler, Matthias Preller, Falk K Hartmann, Hemma Brandstaetter, John Kendrick-Jones, Georgios Tsiavaliaris, Herwig O Gutzeit, Roman Fedorov, Folma Buss, Hans-Joachim Knölker, Lynne M Coluccio, Dietmar J Manstein
Aug 20, 2020
Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Feb 18, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
May 22, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
Anthoceros genomes illuminate the origin of land plants and the unique biology of hornworts.
Fay-Wei Li, Tomoaki Nishiyama, Manuel Waller, Eftychios Frangedakis, Jean Keller, Zheng Li, Noe Fernandez-Pozo, Michael S Barker, Tom Bennett, Miguel A Blázquez, Shifeng Cheng, Andrew C Cuming, Jan de Vries, Sophie de Vries, Pierre-Marc Delaux, Issa S Diop, C Jill Harrison, Duncan Hauser, Jorge Hernández-García, Alexander Kirbis, John C Meeks, Isabel Monte, Sumanth K Mutte, Anna Neubauer, Dietmar Quandt, Tanner Robison, Masaki Shimamura, Stefan A Rensing, Juan Carlos Villarreal, Dolf Weijers, Susann Wicke, Gane K-S Wong, Keiko Sakakibara, Péter Szövényi
Apr 27, 2021
IDO1+ Paneth cells promote immune escape of colorectal cancer.
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Jun 02, 2020
Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an...
Report from the second cytomegalovirus and immunosenescence workshop.
Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Griffiths, Sian Henson, Dietmar Herndler-Brandstetter, Ann Hill, Florian Kern, Paul Klenerman, Derek Macallan, Richard Macualay, Andrea B Maier, Gavin Mason, David Melzer, Matthew Morgan, Paul Moss, Janko Nikolich-Zugich, Annette Pachnio, Natalie Riddell, Ryan Roberts, Paolo Sansoni, Delphine Sauce, John Sinclair, Rafael Solana, Jan Strindhall, Piotr Trzonkowski, Rene van Lier, Rosanna Vescovini, George Wang, Rudi Westendorp, Graham Pawelec
Nov 22, 2011
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume.
Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P Prins, Janine F Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L Min, Lærke Sass, Paul RHJ Timmers, UK10K consortium, George Davey Smith, Simon E Fisher, James F Wilson, Tim J Cole, Dietmar Fernandez-Orth, Klaus Bønnelykke, Hans Bisgaard, Craig E Pennell, Vincent WV Jaddoe, George Dedoussis, Nicholas Timpson, Eleftheria Zeggini, Veronique Vitart, Beate St Pourcain
Oct 14, 2019
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition...
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus
Puya Gharahkhani, Rebecca C Fitzgerald, Thomas L Vaughan, Claire Palles, Ines Gockel, Ian Tomlinson, Matthew F Buas, Andrea May, Christian Gerges, Mario Anders, Jessica Becker, Nicole Kreuser, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Hendrik Manner, Claudia Schmidt, Timo Hess, Anne C Böhmer, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Andreas Hackelsberger, Rupert Mayershofer, Oliver Pech, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), Esophageal Adenocarcinoma GenEtics Consortium (EAGLE), Wellcome Trust Case Control Consortium 2 (WTCCC2), Stephen Attwood, Hugh Barr, Laura Chegwidden, John de Caestecker, Rebecca Harrison, Sharon B Love, David MacDonald, Paul Moayyedi, Hans Prenen, RG Peter Watson, Prasad G Iyer, Lesley A Anderson, Leslie Bernstein, Wong-Ho Chow, Laura J Hardie, Jesper Lagergren, Geoffrey Liu, Harvey A Risch, Anna H Wu, Weimin Ye, Nigel C Bird, Nicholas J Shaheen, Marilie D Gammon, Douglas A Corley, Carlos Caldas, Susanne Moebus, Michael Knapp, Wilbert HM Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Stuart MacGregor, Paul Pharoah, David C Whiteman, Janusz Jankowski, Johannes Schumacher
Sep 29, 2018
BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with...
No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma
Jing Dong, Puya Gharahkhani, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Anna H Wu, Weimin Ye, Lynn Onstad, Lesley A Anderson, Leslie Bernstein, Paul D Pharoah, Harvey A Risch, Douglas A Corley, Rebecca C Fitzgerald, Stomach and Esophageal Cancer Study Consortium, Prasad G Iyer, Brian J Reid, Jesper Lagergren, Nicholas J Shaheen, Thomas L Vaughan, Stuart MacGregor, Sharon Love, Claire Palles, Ian Tomlinson, Ines Gockel, Andrea May, Christian Gerges, Mario Anders, Anne C Böhmer, Jessica Becker, Nicole Kreuser, Rene Thieme, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Claudia Schmidt, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Rupert Mayershofer, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Susanne Moebus, Michael Knapp, Wilbert HM Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Janusz Jankowski, Johannes Schumacher, Rachel E Neale, David C Whiteman, Aaron P Thrift
Nov 01, 2019
BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study...
LATE-NC staging in routine neuropathologic diagnosis
Peter T Nelson, Edward B Lee, Matthew D Cykowski, Irina Alafuzoff, Konstantinos Arfanakis, Johannes Attems, Carol Brayne, Maria M Corrada, Brittany N Dugger, Margaret E Flanagan, Bernardino Ghetti, Lea T Grinberg, Murray Grossman, Michel J Grothe, Glenda M Halliday, Masato Hasegawa, Suvi RK Hokkanen, Sally Hunter, Kurt Jellinger, Claudia H Kawas, C Dirk Keene, Naomi Kouri, Gabor G Kovacs, James B Leverenz, Caitlin S Latimer, Ian R Mackenzie, Qinwen Mao, Kirsty E McAleese, Richard Merrick, Thomas J Montine, Melissa E Murray, Liisa Myllykangas, Sukriti Nag, Janna H Neltner, Kathy L Newell, Robert A Rissman, Yuko Saito, S Ahmad Sajjadi, Katherine E Schwetye, Andrew F Teich, Dietmar R Thal, Sandra O Tomé, Juan C Troncoso, Shih-Hsiu J Wang, Charles L White, Thomas Wisniewski, Hyun-Sik Yang, Julie A Schneider, Dennis W Dickson, Manuela Neumann
Jan 19, 2023
An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and...