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Foix-Chavany-Marie syndrome secondary to bilateral traumatic operculum injury.
This report describes a case of a 62-year-old man who developed Foix-Chavany-Marie syndrome subsequent to traumatic brain injury. The initial presentation of the syndrome was profound loss of voluntary control of orofacial...
Incarnate Quested Speaking
Patrick Brown
Jun 23, 2022
Patrick Brown is an independent scholar in Honolulu, Hawaii. Before moving to Hawaii, he taught in the philosophy department and the school of law at Seattle University. Brown received his Ph.D. in philosophy from Boston...
Published by: Memorial University of Newfoundland
Incarnate Quested Speaking
Patrick Brown
Jun 23, 2022
Patrick Brown is an independent scholar in Honolulu, Hawaii. Before moving to Hawaii, he taught in the philosophy department and the school of law at Seattle University. Brown received his Ph.D. in philosophy from Boston...
Published by: Memorial University of Newfoundland
Neurological update
Coronavirus Disease 2019 is predominantly a disorder of the respiratory system, but neurological complications have been recognised since early in the pandemic. The major pathophysiological processes leading to neurological...
Neurological update
Abstract: Coronavirus Disease 2019 is predominantly a disorder of the respiratory system, but neurological complications have been recognised since early in the pandemic. The major pathophysiological processes leading to...
A method to isolate and cryopreserve cerebrospinal fluid mononuclear cells from external ventricular drains to investigate immunological processes in acute brain injuries.
The inflammatory response to acute brain injuries is a key contributor to subsequent outcome. The study of local central nervous system inflammatory responses is hindered by raised intracranial pressure precluding cerebrospinal...
Cholinergic modulation of Up-Down states in the mouse medial entorhinal cortex in vitro.
Y Audrey Hay, Przemyslaw Jarzebowski, Yu Zhang, Richard Digby, Viktoria Brendel, Ole Paulsen, Vincent Magloire
Nov 03, 2020
Cholinergic tone is high during wake and rapid eye movement sleep and lower during slow wave sleep (SWS). Nevertheless, the low tone of acetylcholine during SWS modulates sharp wave ripple incidence in the hippocampus and slow...
Teaching Foundations in Peace Studies
Robert Henman
Oct 20, 2010
This article explores the relation of serious theoretical reflection to effective teaching and practice. The article explores the curiosity of the human person as a foundation to Peace Studies. It also attempts to show that...
Published by: Memorial University of Newfoundland
Teaching Foundations in Peace Studies
Robert Henman
Oct 20, 2010
This article explores the relation of serious theoretical reflection to effective teaching and practice. The article explores the curiosity of the human person as a foundation to Peace Studies. It also attempts to show that...
Published by: Memorial University of Newfoundland
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections.
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P Boyle, Betsaida Bibo-Verdugo, Robert J Pickering, Steven J Webster, Thomas P Monie, Lee J Hopkins, Nobuhiko Kayagaki, Guy S Salvesen, Soren Warming, Lucy Weinert, Clare E Bryant
Aug 06, 2021
Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage...
Carnivora NLRC4 NLRP3 Caspase 1 caspase 11 caspase 4 inflammasome Animals Carnivora Caspase 1 Caspase 8 Caspases Initiator Cell Death Cell Line evolution Molecular Humans Inflammasomes Interleukin-1beta Lipopolysaccharides MACROPHAGES Mice Mice Inbred C57BL NLR proteins Recombinant Fusion Proteins Recombinant Proteins Salmonella typhi Zoonoses
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.
Catherine M Scahill, Zsofia Digby, Ian M Sealy, Sonia Wojciechowska, Richard J White, John E Collins, Derek L Stemple, Till Bartke, Marie E Mathers, E Elizabeth Patton, Elisabeth M Busch-Nentwich
Jun 20, 2018
KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes...
Animals DNA Replication Disease Models Animal Epigenesis Genetic Exome Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Knockout Techniques Jumonji Domain-Containing Histone Demethylases Male Melanoma Mutation Proto-Oncogene Proteins B-raf RNA Messenger Sequence Analysis RNA Zebrafish Zebrafish Proteins
The Influence of HIV on the Evolution of Mycobacterium tuberculosis.
Anastasia S Koch, Daniela Brites, David Stucki, Joanna C Evans, Ronnett Seldon, Alexa Heekes, Nicola Mulder, Mark Nicol, Tolu Oni, Valerie Mizrahi, Digby F Warner, Julian Parkhill, Sebastien Gagneux, Darren P Martin, Robert J Wilkinson
Sep 10, 2019
HIV significantly affects the immunological environment during tuberculosis coinfection, and therefore may influence the selective landscape upon which M. tuberculosis evolves. To test this hypothesis whole genome sequences were...
A high-resolution mRNA expression time course of embryonic development in zebrafish.
Richard J White, John E Collins, Ian M Sealy, Neha Wali, Christopher M Dooley, Zsofia Digby, Derek L Stemple, Daniel N Murphy, Konstantinos Billis, Thibaut Hourlier, Anja Füllgrabe, Matthew P Davis, Anton J Enright, Elisabeth M Busch-Nentwich
Feb 12, 2018
We have produced an mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos. Using poly(A) pulldown stranded RNA-seq and a 3'...
Effectiveness and safety of vedolizumab in inflammatory bowel disease patients aged 60 and over
Hajir Ibraheim, Mark A Samaan, Ashish Srinivasan, Oliver Brain, Jonathan Digby-Bell, Peter M Irving, Irena Norman, Issrah Jawad, Julia Biedermann, Ana Ibarra, Klaartje Bel Kok, Gareth Parkes, Joanna Rimmer, Elisabeta Compot, Miles Parkes, Jonathan Segal, Philip Oppong, Ailsa Hart, Bu'Hussain Hayee, Nick Powell
Feb 03, 2021
BACKGROUND: The GEMINI trials established the efficacy of vedolizumab in moderate-to-severe inflammatory bowel disease (IBD) and demonstrated a favorable safety profile, suggesting it may be advantageous in older patients at...
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Dec 17, 2019
OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22...
ER stress Interleukin 22 inflammatory bowel disease Animals Anti-Bacterial Agents Apoptosis Cell Survival Chronic Disease Colitis Colon Crohn Disease Disease Models Animal Endoplasmic reticulum stress Epithelial Cells Gastrointestinal Agents Humans Interleukin-17 Interleukin-23 Interleukins Intestinal Mucosa Mice Organoids Patient acuity Phenylbutyrates Recombinant Proteins Transcription Genetic Tunicamycin Unfolded Protein Response Ustekinumab
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Edward J Needham, Alexander L Ren, Richard J Digby, Emma J Norton, Soraya Ebrahimi, Joanne G Outtrim, Doris A Chatfield, Anne E Manktelow, Maya M Leibowitz, Virginia FJ Newcombe, Rainer Doffinger, Gabriela Barcenas-Morales, Claudia Fonseca, Michael J Taussig, Rowan M Burnstein, Romit J Samanta, Cordelia Dunai, Nyarie Sithole, Nicholas J Ashton, Henrik Zetterberg, Magnus Gisslén, Arden Edén, Emelie Marklund, Peter JM Openshaw, Jake Dunning, Michael J Griffiths, Jonathan Cavanagh, Gerome Breen, Sarosh R Irani, Anne Elmer, Nathalie Kingston, Charlotte Summers, John R Bradley, Leonie S Taams, Benedict D Michael, Edward T Bullmore, Kenneth GC Smith, Paul A Lyons, Alasdair J Coles, David K Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility
Oct 06, 2022
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19...
A classification system for teachers’ motivational behaviors recommended in self-determination theory interventions.
Asghar Ahmadi, Michael Noetel, Philip David Parker, Richard M. Ryan, Nikos Ntoumanis, Johnmarshall Reeve, Mark R. Beauchamp, Theresa Dicke, Alexander Yeung, Malek Ahmadi, Kimberley Bartholomew, Thomas K. F. Chiu, Thomas Curran, Gokce Erturan, Barbara Flunger, Christina Frederick, John Mark Froiland, David González-Cutre, Leen Haerens, Lucas Matias Jeno, Andre Koka, Christa Krijgsman, Jody Langdon, Rhiannon Lee White, David Litalien, David Lubans, John Mahoney, Ma Jenina N. Nalipay, Erika Patall, Dana Perlman, Eleanor Quested, Sascha Schneider, Martyn Standage, Kim Stroet, Damien Tessier, Cecilie Thogersen-Ntoumani, Henri Tilga, Diego Vasconcellos, Chris Lonsdale
May 18, 2023
Teachers’ behavior is a key factor that influences students’ motivation. Many theoretical models have tried to explain this influence, with one of the most thoroughly researched being self-determination theory (SDT). We used...
A classification system for teachers’ motivational behaviors recommended in self-determination theory interventions.
Asghar Ahmadi, Michael Noetel, Philip David Parker, Richard M. Ryan, Nikos Ntoumanis, Johnmarshall Reeve, Mark R. Beauchamp, Theresa Dicke, Alexander Yeung, Malek Ahmadi, Kimberley Bartholomew, Thomas K. F. Chiu, Thomas Curran, Gokce Erturan, Barbara Flunger, Christina Frederick, John Mark Froiland, David González-Cutre, Leen Haerens, Lucas Matias Jeno, Andre Koka, Christa Krijgsman, Jody Langdon, Rhiannon Lee White, David Litalien, David Lubans, John Mahoney, Ma Jenina N. Nalipay, Erika Patall, Dana Perlman, Eleanor Quested, Sascha Schneider, Martyn Standage, Kim Stroet, Damien Tessier, Cecilie Thogersen-Ntoumani, Henri Tilga, Diego Vasconcellos, Chris Lonsdale
May 18, 2023
Teachers’ behavior is a key factor that influences students’ motivation. Many theoretical models have tried to explain this influence, with one of the most thoroughly researched being self-determination theory (SDT). We used...
Complete vertebrate mitogenomes reveal widespread repeats and gene duplications
Giulio Formenti, Arang Rhie, Jennifer Balacco, Bettina Haase, Jacquelyn Mountcastle, Olivier Fedrigo, Samara Brown, Marco Rosario Capodiferro, Farooq O. Al-Ajli, Roberto Ambrosini, Peter Houde, Sergey Koren, Karen Oliver, Michelle Smith, Jason Skelton, Emma Betteridge, Jale Dolucan, Craig Corton, Iliana Bista, James Torrance, Alan Tracey, Jonathan Wood, Marcela Uliano-Silva, Kerstin Howe, Shane McCarthy, Sylke Winkler, Woori Kwak, Jonas Korlach, Arkarachai Fungtammasan, Daniel Fordham, Vania Costa, Simon Mayes, Matteo Chiara, David S. Horner, Eugene Myers, Richard Durbin, Alessandro Achilli, Edward L. Braun, Adam M. Phillippy, Erich D. Jarvis, Alexander N. G. Kirschel, Andrew Digby, Andrew Veale, Anne Bronikowski, Bob Murphy, Bruce Robertson, Clare Baker, Camila Mazzoni, Christopher Balakrishnan, Chul Lee, Daniel Mead, Emma Teeling, Erez Lieberman Aiden, Erica Todd, Evan Eichler, Gavin J. P. Naylor, Guojie Zhang, Jeramiah Smith, Jochen Wolf, Justin Touchon, Kira Delmore, Kjetill Jakobsen, Lisa Komoroske, Mark Wilkinson, Martin Genner, Martin Pšenička, Matthew Fuxjager, Mike Stratton, Miriam Liedvogel, Neil Gemmell, Piotr Minias, Peter O. Dunn, Peter Sudmant, Phil Morin, Qasim Ayub, Robert Kraus, Sonja Vernes, Steve Smith, Tanya Lama, Taylor Edwards, Tim Smith, Tom Gilbert, Tomas Marques-Bonet, Tony Einfeldt, Byrappa Venkatesh, Warren Johnson, Wes Warren, Yury Bukhman
Apr 29, 2021
Abstract: Background: Modern sequencing technologies should make the assembly of the relatively small mitochondrial genomes an easy undertaking. However, few tools exist that address mitochondrial assembly directly. Results: As...
Towards complete and error-free genome assemblies of all vertebrate species.
Arang Rhie, Shane A McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L Gedman, Lindsey J Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jason Howard, Sonja C Vernes, Tanya M Lama, Frank Grutzner, Wesley C Warren, Christopher N Balakrishnan, Dave Burt, Julia M George, Matthew T Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F Kautt, Paolo Franchini, H William Detrich, Hannes Svardal, Maximilian Wagner, Gavin JP Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B Kingan, Richard Hall, Zev Kronenberg, Ivan Sović, Christopher Dunn, Zemin Ning, Alex Hastie, Joyce Lee, Siddarth Selvaraj, Richard E Green, Nicholas H Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E Dagnew, Dengfeng Guan, Sarah E London, David F Clayton, Claudio V Mello, Samantha R Friedrich, Peter V Lovell, Ekaterina Osipova, Farooq O Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S Harris, Kateryna D Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kevin Howe, Paul Flicek, Brian P Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert HS Kraus, Andrew J Crawford, M Thomas P Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert W Murphy, Klaus-Peter Koepfli, Beth Shapiro, Warren E Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma C Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A Ryder, David Haussler, Stephen J O'Brien, Jonas Korlach, Harris A Lewin, Kerstin Howe, Eugene W Myers, Richard Durbin, Adam M Phillippy, Erich D Jarvis
Jul 05, 2021
High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are available for only a few non-microbial...
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