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Results: 52
Nanoscale click-reactive scaffolds from peptide self-assembly.
Alexander Guttenplan, Laurence J Young, Dijana Matak Vinkovic, Clemens Kaminski, Tuomas Knowles, Laura Itzhaki
May 03, 2018
Background
Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as...
Purification of Recombinant α-synuclein
Amberley D Stephens, Dijana Matak-Vinkovic, Ana Fernandez-Villegas, Gabriele S Kaminski Schierle
Nov 23, 2020
The initial state of the intrinsically disordered protein α-synuclein (aSyn), e.g., the presence of oligomers and degradation products, or the presence of contaminants and adducts can greatly influence the aggregation kinetics...
Cell Line Cell Survival Chemical Precipitation Chromatography Gel Chromatography Ion Exchange Chromatography Liquid Escherichia coli Humans Intrinsically Disordered Proteins Microscopy Electron Transmission Protein Aggregates Protein Conformation Protein Conformation beta-Strand Recombinant Proteins Spectrometry Mass Electrospray Ionization ALPHA-SYNUCLEIN
An artificial CO-releasing metalloprotein built by histidine-selective metallation.
Inês S Albuquerque, Hélia F Jeremias, Miguel Chaves-Ferreira, Dijana Matak-Vinkovic, Omar Boutureira, Carlos C Romão, Gonçalo JL Bernardes
Apr 28, 2015
Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes.
Heather A Bruce, Dijun Du, Dijana Matak-Vinkovic, Katarzyna J Bandyra, R William Broadhurst, Esther Martin, Frank Sobott, Alexander V Shkumatov, Ben F Luisi
Jun 01, 2018
The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA metabolism of Escherichia coli and numerous other bacterial species including pathogens. At the core of the assembly is the endoribonuclease...
Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice.
Miguel Chaves-Ferreira, Inês S Albuquerque, Dijana Matak-Vinkovic, Ana C Coelho, Sandra M Carvalho, Lígia M Saraiva, Carlos C Romão, Gonçalo JL Bernardes
Mar 17, 2015
CORM albumin carbon monoxide metalloproteins prodrugs Animals Carbon Monoxide Cattle Cell Line Tumor Female HeLa Cells Histidine Humans Interleukin-10 Interleukin-6 Mass Spectrometry Mice Mice Inbred BALB C Neoplasms Organometallic Compounds Prodrugs Serum Albumin Bovine Tissue Distribution Transplantation Heterologous Tumor Necrosis Factor-alpha
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems.
Tuuli A Hakala, Emma V Yates, Pavan K Challa, Zenon Toprakcioglu, Karthik Nadendla, Dijana Matak-Vinkovic, Christopher M Dobson, Rodrigo Martínez, Francisco Corzana, Tuomas P J Knowles, Gonçalo J L Bernardes
Nov 04, 2021
Published by: Journal of the American Chemical Society
Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.
Jude Chenge, Madeline E Kavanagh, Max D Driscoll, Kirsty J McLean, Douglas B Young, Teresa Cortes, Dijana Matak-Vinkovic, Colin W Levy, Stephen EJ Rigby, David Leys, Chris Abell, Andrew W Munro
Jan 16, 2018
Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the human host....
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems.
Tuuli A Hakala, Emma V Yates, Pavan K Challa, Zenon Toprakcioglu, Karthik Nadendla, Dijana Matak-Vinkovic, Christopher M Dobson, Rodrigo Martínez, Francisco Corzana, Tuomas PJ Knowles, Gonçalo JL Bernardes
Sep 16, 2021
Biomimetics is a design principle within chemistry, biology, and engineering, but chemistry biomimetic approaches have been generally limited to emulating nature's chemical toolkit while emulation of nature's physical toolkit...
A multidrug ABC transporter with a taste for salt.
Saroj Velamakanni, Calvin HF Lau, Daniel AP Gutmann, Henrietta Venter, Nelson P Barrera, Markus A Seeger, Barbara Woebking, Dijana Matak-Vinkovic, Lekshmy Balakrishnan, Yao Yao, Edmond CY U, Richard A Shilling, Carol V Robinson, Peter Thorn, Hendrik W van Veen
Oct 05, 2020
BACKGROUND: LmrA is a multidrug ATP-binding cassette (ABC) transporter from Lactococcus lactis with no known physiological substrate, which can transport a wide range of chemotherapeutic agents and toxins from the cell. The...
Fragment screening against the EthR-DNA interaction by native mass spectrometry
DSH Chan, V Mendes, S Thomas, B McConnell, D Matak-Vinkovic, A Coyne, T Blundell, C Abell
Aug 18, 2017
Native nanoelectrospray ionization mass spectrometry is an underutilized technique for fragment screening. In this study, the first demonstration is provided of the use of native mass spectrometry for screening fragments against...
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
Erwin De Genst, Dimitri Y Chirgadze, Fabrice AC Klein, David C Butler, Dijana Matak-Vinković, Yvon Trottier, James S Huston, Anne Messer, Christopher M Dobson
May 27, 2015
Huntington's disease aggregation inhibition Amyloid prefibrillar intermediates single-chain Fv antibody Amyloid Chemical Phenomena Crystallography X-Ray Humans Huntingtin Protein Magnetic Resonance Spectroscopy Models Molecular Nerve Tissue Proteins Protein Binding Protein Multimerization Protein Structure Quaternary Single-Chain Antibodies
Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase
F Villa, AC Simon, MA Ortiz Bazan, ML Kilkenny, D Wirthensohn, M Wightman, D Matak-Vinkovíc, L Pellegrini, K Labib
Apr 11, 2017
Binding Sites Chromosomes Fungal DNA Helicases DNA Polymerase I DNA Fungal DNA Ribosomal DNA-Binding Proteins Gene Dosage Intracellular Signaling Peptides and Proteins Models Molecular Multiprotein Complexes Mutation Protein Binding Protein Interaction Domains and Motifs S Phase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Structure-Activity Relationship
Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin
S Holzer, G Degliesposti, ML Kilkenny, SL Maslen, D Matak-Vinkovíc, M Skehel, L Pellegrini
Apr 11, 2017
Biophysical Phenomena Carrier Proteins Cell Cycle Proteins Cross-Linking Reagents Crystallography X-Ray DNA-Binding Proteins Humans Intracellular Signaling Peptides and Proteins Mass Spectrometry Models Molecular Nuclear Proteins Protein Binding Protein Domains Protein Multimerization Structural Homology Protein
Structural insights into the EthR-DNA interaction using native mass spectrometry
DSH Chan, WG Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Blaszczyk, AG Coyne, TL Blundell, C Abell
Mar 09, 2017
Plasma marker for systemic inflammation is increased in Mexican Tarahumara following ultra-distance running.
Peter Durand Skottrup, Thomas Kallemose, Diana Espino, Rocio Infante-Ramirez, Soren Brage, Dijana Terzic, Jens Peter Goetze, Jesper Kjaergaard, Dirk Lund Christensen
Aug 17, 2020
Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara.
Dirk L Christensen, Diana Espino, Rocío Infante-Ramírez, Mónica S Cervantes-Borunda, Rosa P Hernández-Torres, Antonio E Rivera-Cisneros, Daniel Castillo, Kate Westgate, Dijana Terzic, Soren Brage, Christian Hassager, Jens P Goetze, Jesper Kjaergaard
Mar 22, 2018
BACKGROUND: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population....
First international workshop of the ATM and cancer risk group (4-5 December 2019).
Fabienne Lesueur, Douglas F Easton, Anne-Laure Renault, Sean V Tavtigian, Jonine L Bernstein, Zsofia Kote-Jarai, Rosalind A Eeles, Dijana Plaseska-Karanfia, Lidia Feliubadaló, Spanish ATM working group, Banu Arun, Natalie Herold, Beatrix Versmold, Rita Katharina Schmutzler, GC-HBOC, Tú Nguyen-Dumont, Melissa C Southey, Leila Dorling, Alison M Dunning, Paola Ghiorzo, Bruna Samia Dalmasso, Eve Cavaciuti, Dorothée Le Gal, Nicholas J Roberts, Mev Dominguez-Valentin, Matti Rookus, Alexander MR Taylor, Alisa M Goldstein, David E Goldgar, CARRIERS and Ambry Groups, Dominique Stoppa-Lyonnet, Nadine Andrieu
Apr 14, 2021
The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated...
The spectrum of BRCA1 and BRCA2 pathogenic sequence variants in Middle Eastern, North African, and South European countries.
Yael Laitman, Tara M Friebel, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Gisella Figlioli, Bernardo Bonanni, Siranoush Manoukian, Monica Zuradelli, Carlo Tondini, Barbara Pasini, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Milena Jakimovska, Keivan Majidzadeh, Shiva Zarinfam, Maria A Loizidou, Andreas Hadjisavvas, Kyriaki Michailidou, Kyriacos Kyriacou, Doron M Behar, Rinat Bernstein Molho, Patricia Ganz, Paul James, Michael T Parsons, Aminah Sallam, Olufunmilayo I Olopade, Arun Seth, Georgia Chenevix-Trench, Goska Leslie, Lesley McGuffog, Makia J Marafie, Andre Megarbane, Fahd Al-Mulla, Timothy R Rebbeck, Eitan Friedman
Jun 20, 2019
BRCA1 BRCA2 mutational spectrum Middle East North Africa first pass genotyping inherited breast cancer underserved populations Africa Northern Alleles BRCA1 Protein BRCA2 Protein Black People Data Mining Databases Genetic Europe Genetic Predisposition to Disease genetic variation Genotype Humans Middle East Population Groups Research Design White People
CYP3A7*1C allele
Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E Jones, Minouk J Schoemaker, Clare Gilham, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Caroline Baynes, Laura E Beane Freeman, Matthias W Beckmann, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, Don M Conroy, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Thilo Dörk, A Heather Eliassen, Christoph Engel, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Giuseppe Floris, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, Mia M Gaudet, Graham G Giles, Mark S Goldberg, Anna González-Neira, AOCS Group, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Steven N Hart, Maartje J Hooning, John L Hopper, Anthony Howell, David J Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Esther M John, Rudolf Kaaks, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Veli-Matti Kosma, Stella Koutros, Peter Kraft, Vessela N Kristensen, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Martha Linet, Jan Lubiński, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John WM Martens, Dimitrios Mavroudis, Rebecca Mayes, Alfons Meindl, Roger L Milne, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Sune F Nielsen, Børge G Nordestgaard, Nadia Obi, Andrew F Olshan, Janet E Olson, Håkan Olsson, Ester Orban, Tjoung-Won Park-Simon, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Katri Pylkäs, Gad Rennert, Hedy S Rennert, Kathryn J Ruddy, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Rita K Schmutzler, Christopher Scott, Xiao-Ou Shu, Jacques Simard, Snezhana Smichkoska, Christof Sohn, Melissa C Southey, John J Spinelli, Jennifer Stone, Rulla M Tamimi, Jack A Taylor, Rob AEM Tollenaar, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Elke M van Veen, Sophia S Wang, Clarice R Weinberg, Camilla Wendt, Hans Wildiers, Robert Winqvist, Alicja Wolk, Wei Zheng, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, A Forbes Howie, Julian Peto, Isabel dos-Santos-Silva, Anthony J Swerdlow, Jenny Chang-Claude, Marjanka K Schmidt, Nick Orr, Olivia Fletcher
Jan 27, 2021
BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary...
Mendelian randomisation study of smoking exposure in relation to breast cancer risk.
Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, Don M Conroy, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Isabel dos-Santos-Silva, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Lin Fritschi, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Gord Glendon, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Elaine F Harkness, Steven N Hart, Wei He, Bernadette AM Heemskerk-Gerritsen, John L Hopper, David J Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Esther M John, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Linetta B Koppert, Stella Koutros, Vessela N Kristensen, Allison W Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Wing-Yee Lo, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Alfons Meindl, Usha Menon, Roger L Milne, Taru A Muranen, Heli Nevanlinna, William G Newman, Børge G Nordestgaard, Kenneth Offit, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Nadege Presneau, Paolo Radice, Gad Rennert, Hedy S Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Minouk J Schoemaker, Lukas Schwentner, Christopher Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Ann Smeets, Melissa C Southey, John J Spinelli, Victoria Stevens, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Elke M van Veen, Joseph Vijai, Sophia Wang, Camilla Wendt, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, Wei Zheng, Peter Kraft, Jenny Chang-Claude
Aug 20, 2021
BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. METHODS: We...
Rare germline copy number variants (CNVs) and breast cancer risk.
Joe Dennis, Jonathan P Tyrer, Logan C Walker, Kyriaki Michailidou, Leila Dorling, Manjeet K Bolla, Qin Wang, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Jose E Castelao, Jenny Chang-Claude, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, J Margriet Collée, CTS Consortium, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Laure Dossus, A Heather Eliassen, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, Graham G Giles, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Per Hall, Antoinette Hollestelle, Reiner Hoppe, John L Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Agnes Jager, Anna Jakubowska, Esther M John, Nichola Johnson, Michael E Jones, Audrey Jung, Rudolf Kaaks, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Yon-Dschun Ko, Veli-Matti Kosma, Stella Koutros, Peter Kraft, Vessela N Kristensen, Katerina Kubelka-Sabit, Allison W Kurian, James V Lacey, Diether Lambrechts, Nicole L Larson, Martha Linet, Alicja Ogrodniczak, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, Roger L Milne, Taru A Muranen, Rachel A Murphy, Heli Nevanlinna, Janet E Olson, Håkan Olsson, Tjoung-Won Park-Simon, Charles M Perou, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Katri Pylkäs, Gad Rennert, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Rana Shibli, Ann Smeets, Penny Soucy, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, Jack A Taylor, Lauren R Teras, Mary Beth Terry, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Camilla Wendt, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Argyrios Ziogas, Jacques Simard, Alison M Dunning, Paul DP Pharoah, Douglas F Easton
Feb 19, 2022
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