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Results: 9
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Amin Mottahedin, Hiran A Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P Murphy, Thomas Krieg
Feb 12, 2023
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Timely reperfusion is critical for salvaging ischemic tissue in myocardial infarction, in stroke, and during resuscitation. Paradoxically, the reperfusion of blood into the ischemic organ is damaging in itself, leading to...
Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker.
Hiran A Prag, Duvaraka Kula-Alwar, Laura Pala, Stuart T Caldwell, Timothy E Beach, Andrew M James, Kourosh Saeb-Parsy, Thomas Krieg, Richard C Hartley, Michael P Murphy
Aug 17, 2020
Many mitochondrial metabolites and bioactive molecules contain two carboxylic acid moieties that make them unable to cross biological membranes. Hence, there is considerable interest in facilitating the uptake of these molecules...
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Coert J Zuurbier, Luc Bertrand, Christoph R Beauloye, Ioanna Andreadou, Marisol Ruiz-Meana, Nichlas R Jespersen, Duvaraka Kula-Alwar, Hiran A Prag, Hans Eric Botker, Maija Dambrova, Christophe Montessuit, Tuuli Kaambre, Edgars Liepinsh, Paul S Brookes, Thomas Krieg
May 15, 2020
Reducing infarct size during a cardiac ischaemic-reperfusion episode is still of paramount importance, because the extension of myocardial necrosis is an important risk factor for developing heart failure. Cardiac...
Structural basis for a complex I mutation that blocks pathological ROS production
Structural basis for a complex I mutation that blocks pathological ROS production.
Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R Bridges, Hiran A Prag, Daniel N Grba, Carlo Viscomi, Andrew M James, Amin Mottahedin, Thomas Krieg, Michael P Murphy, Judy Hirst
Feb 17, 2021
Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation...
Amino Acid Substitution Animals Cryoelectron Microscopy DNA Mitochondrial Disease Models Animal Disease Resistance Electron Transport Electron Transport Complex I Humans Isolated Heart Preparation Leucine Male Mice Mice Transgenic Mitochondria Mitochondrial Membranes Myocardial Reperfusion Injury NAD NADH Dehydrogenase Oxidation-Reduction Point Mutation Proline Reactive Oxygen Species
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury.
Hiran A Prag, Dunja Aksentijevic, Andreas Dannhorn, Abigail V Giles, John F Mulvey, Olga Sauchanka, Luping Du, Georgina Bates, Johannes Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, Luc Pellerin, Richard JA Goodwin, Michael P Murphy, Thomas Krieg
Sep 12, 2022
BACKGROUND: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the...
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Hiran A Prag, Laura Pala, Duvaraka Kula-Alwar, John F Mulvey, Du Luping, Timothy E Beach, Lee M Booty, Andrew R Hall, Angela Logan, Volha Sauchanka, Stuart T Caldwell, Ellen L Robb, Andrew M James, Zhelong Xu, Kourosh Saeb-Parsy, Richard C Hartley, Michael P Murphy, Thomas Krieg
Jan 28, 2022
PURPOSE: Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accumulates and its...
Drug delivery Ischemia/reperfusion injury Malonate Mitochondria Succinate Animals Cardiotonic Agents Cell Line Disease Models Animal Esters Female Humans Male Malonates Mice Mice Inbred C57BL Mitochondria Myocardial Infarction Myocardial Reperfusion Injury prodrugs Rats Rats Wistar Reactive Oxygen Species Succinic Acid
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Hiran Prag, Laura Pala, Duvaraka Kula-Alwar, John F Mulvey, Du Luping, Timothy E Beach, Lee M Booty, Andrew R Hall, Angela Logan, Volha Sauchanka, Stuart T Caldwell, Ellen L Robb, Andrew James, Zhelong Xu, Kourosh Saeb-Parsy, Richard C Hartley, Mike Murphy, Thomas Krieg
Jul 30, 2020
PURPOSE: Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accumulates and its...