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Interview with Edward "Ed" Harris, Brenda Dow, and Sylvester King - OH 296
In May of 2013 Mr. Edward Harris sat down and discussed his brother, Herman K. Harris, who was a part of the freedom riders. Mr. Harris also discusses his military service and his tour of duty in Vietnam. This interview was...
Sharecropper African American education Southern Family Heath Springs South Carolina Segregation Freedom Riders KKK Vietnam PTSD Oral History
Published by: Winthrop University
Interview with Edward Bynum - OH 322
This collection includes an interview of Edward Bynum (1933-2012) concerning his work with the Dr. James R. Clark Memorial Sickle Cell Anemia Foundation. Bynum discusses his education, his service in the Korean War on a hospital...
Sickle cell anemia and trait Thalassemia James R. Clark Memorial Sickle Cell Foundation CDC (Centers for Disease Control and Prevention) DHEC (Department of Health and Environmental Control) Hematology Dr. James R. Clark Oral History
Published by: Winthrop University
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to...
de Sitter Microstates from $T\bar T+Λ_2$ and the Hawking-Page
Transition
Evan Coleman, Edward A Mazenc, Vasudev Shyam, Eva Silverstein, Ronak Soni, Gonzalo Torroba, Sungyeon Yang
Jul 28, 2022
We obtain microstates accounting for the Gibbons-Hawking entropy in $dS_3$,
along with a subleading logarithmic correction, from the solvable $T\bar
T+\Lambda_2$ deformation of a seed CFT with sparse light spectrum....
Published by: Springer Berlin Heidelberg
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Mar 14, 2020
INTRODUCTION:The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. OBJECTIVE:To test if abnormal birth...
Published by: BMJ open diabetes research & care
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.
Meryem Aloulou, Edward J Carr, Mylène Gador, Alexandre Bignon, Roland S Liblau, Nicolas Fazilleau, Michelle A Linterman
Jun 24, 2019
T follicular regulatory (Tfr) cells are a subset of Foxp3(+) regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response....
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
Birth weight, family history of diabetes and diabetes onset in schizophrenia
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Feb 10, 2020
Introduction: The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. Objective: To test if abnormal...
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Jan 08, 2020
The Grizzly, February 7, 1995
Marc Ellman, Mark Leiser, Jayson Blocksidge, Michelle Ryan, Phil Caiazzo, Amy K. Davenport, Tarik Qasim, Nicole D'orsaneo, Michael A. Pizzi, Doug Plitt, Fred Klee, Joel Schofer, Ellen Cosgrove, Charlie Weingroff
Jan 01, 0001
Faculty and Administrators Focus on Sophomore Concerns Survey of Ursinus Freshmen Voice of Ursinus Rings Clear Border Dispute Between Ecuador and Peru Tabby Buckingham Dies at 16 Ursinus Students Attend March for Life ...
Ursinus College Collegeville Pennsylvania newspaper gymnastics Basketball Swimming Bridget Cauley Ellen Cosgrove campus security WVOU radio station Abortion Tabby Buckingham Michelle Ryan CIRP Sophomore Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Functional proteomic atlas of HIV infection in primary human CD4+ T cells.
Adi Naamati, James C Williamson, Edward JD Greenwood, Sara Marelli, Paul J Lehner, Nicholas J Matheson
Mar 28, 2019
Viruses manipulate host cells to enhance their replication, and the identification of cellular factors targeted by viruses has led to key insights into both viral pathogenesis and cell biology. In this study, we develop an HIV...
HIV human immunology infectious disease Inflammation magnetic cell selection microbiology primary human CD4+ T cell Proteomics Virus CD4-Positive T-Lymphocytes Cell Separation Cluster Analysis DNA-Binding Proteins Fragile X Mental Retardation Protein Gene Expression Regulation Green Fluorescent Proteins HIV Infections HIV-1 Humans Hydrogen-Ion Concentration Lentivirus Lymphocyte Activation Magnetics Methyltransferases Protein Binding Protein Tyrosine Phosphatase Non-Receptor Type 22 Proteome Proteomics Streptavidin Virus Replication vif Gene Products Human Immunodeficiency Virus
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Edward Jenkins, Markus Körbel, Caitlin O'Brien-Ball, James McColl, Kevin Y Chen, Mateusz Kotowski, Jane Humphrey, Anna H Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F Lee, Simon J Davis, David Klenerman
Apr 17, 2023
T cells use finger-like protrusions called 'microvilli' to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a...
T-Lymphocytes microvilli Receptors Antigen T-Cell Antigens Lymphocyte Activation Signal Transduction
Published by: Nature Communications
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
INFIDELS IN ENGLISH LEGAL THOUGHT
English common law reports are dense with ideas. Yet they remain mostly untapped by intellectual historians. This article reveals how intellectual history can engage with law and jurisprudence by following the notion...
EDWARD CAVANAGH
Sep 08, 2018
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G Ryan, Michael P Murphy, Christian Frezza, Hiran A Prag, Edward T Chouchani, Luke A O'Neill, Evanna L Mills
Feb 12, 2019
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into underlying mechanisms of disease. Metabolites traditionally associated with...
A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.
Eoin F McKinney, Paul A Lyons, Edward J Carr, Jane L Hollis, David RW Jayne, Lisa C Willcocks, Maria Koukoulaki, Alvis Brazma, Vojislav Jovanovic, D Michael Kemeny, Andrew J Pollard, Paul A Macary, Afzal N Chaudhry, Kenneth GC Smith
Nov 24, 2020
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based...
Antibodies Antineutrophil Cytoplasmic Autoimmune Diseases Autoimmunity CD8-Positive T-Lymphocytes Cohort Studies Dose-Response Relationship Drug Gene Expression Humans Immunosuppressive Agents Inflammation Interleukin-7 Lupus Erythematosus Systemic Prognosis Receptors Antigen T-Cell Signal Transduction T-Lymphocytes Vasculitis
Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia.
Emilio Fernandez-Egea, Petra E Vértes, Shaun M Flint, Lorinda Turner, Syed Mustafa, Alex Hatton, Kenneth GC Smith, Paul A Lyons, Edward T Bullmore
Sep 05, 2018
BACKGROUND: Hypothetically, psychotic disorders could be caused or conditioned by immunological mechanisms. If so, one might expect there to be peripheral immune system phenotypes that are measurable in blood cells as biomarkers...
Adult Antipsychotic Agents Biomarkers CD4 Lymphocyte Count Case-Control Studies Clozapine Cognitive Dysfunction Cross-Sectional Studies Dendritic Cells Female Flow Cytometry HLA-DR Antigens Humans Immunologic Memory Killer Cells Natural Lymphocyte Activation Male Middle Aged Receptors Dopamine D3 Schizophrenia T-Lymphocyte Subsets T-Lymphocytes Regulatory Young Adult
A meta-analysis of techniques to promote motivation for health behaviour change from a self-determination theory perspective
A systematic review and meta-analysis was conducted of the techniques used to promote psychological need satisfaction and motivation within health interventions based on self-determination theory (SDT; Ryan & Deci, 2017)....
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