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High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jul 05, 2021
Adolescent Adult Aged Animals Asymmetric cell division Cell Differentiation Cell Proliferation Centrosome Child Child Preschool Embryo Mammalian epidermis Female Hair Follicle Humans Keratinocytes Male Mice Mice Knockout Middle Aged Models Biological Skin Physiological Phenomena Spindle Apparatus Time-Lapse Imaging Tumor Suppressor Protein p53 Tumor Suppressor p53-Binding Protein 1 Ubiquitin Thiolesterase Young Adult
High proliferation and delamination during skin epidermal stratification
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D. Simons, Hisham Bazzi
May 28, 2021
Abstract: The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jun 29, 2021
The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
epidermis Hair Follicle Centrosome Keratinocytes Animals Mice Knockout Humans Mice Ubiquitin Thiolesterase Cell Differentiation Cell Proliferation Models Biological Adolescent Adult Aged Middle Aged Child Child Preschool Female Male Tumor Suppressor Protein p53 Embryo Mammalian Skin Physiological Phenomena Young Adult Time-Lapse Imaging Asymmetric cell division Spindle Apparatus Tumor Suppressor p53-Binding Protein 1
Published by: Nature Communications
Smartization in Gatchina
In the paper, a case of a Russian town, Gatchina, is examined to find the reasonable balance between international smart city practice, governmental requirements, historical identity preservation, and human-oriented approach....
Published by: IGI Global Scientific Publishing
Coalgebraic logic programming
Corecursive definitions, such as that of a stream, may often be described by elegant logic programs, but ones for which SLD-refutation is of no value while infinite SLD-derivations are of considerable value. Such definitions...
Logic programming
A propositional logic program P may be identified with a P f P f -coalgebra on the set of atomic propositions in the program. The corresponding C(P f P f )-coalgebra, where C(P f P f ) is the cofree comonad on P f P f ...
Logic programming
A propositional logic program P may be identified with a P f P f -coalgebra on the set of atomic propositions in the program. The corresponding C(P f P f )-coalgebra, where C(P f P f ) is the cofree comonad on P f P f ...
Strategic Role of Alumni Associations of Kazakhstan Higher Educational Institutions in Achieving Sustainable Development Goals
The research aims to comprehend the strategic role of alumni associations of Kazakhstan's higher educational institutions in achieving environmental, social, and governance (ESG) sustainability initiatives. The study...
Published by: IGI Global Scientific Publishing
Coalgebraic logic programming
Corecursive definitions, such as that of a stream, may often be described by elegant logic programs, but ones for which SLD-refutation is of no value while infinite SLD-derivations are of considerable value. Such definitions...
Public views of the Sustainable Development Goals across countries
Paul Bain, Pieter M. Kroonenberg, Lars-Olof Johansson, Taciano l. Milfont, Charlie Crimston, Timothy Robert Kurz, Ekaterina Bushina, Carolina Calligaro, Christophe Demarque, Yanjun Guan, Joonha Park
Sep 30, 2019
The United Nation’s 17 Sustainable Development Goals (SDGs) offer an extensive framework for coordinating and shaping government policies, and for engaging the public with sustainability. Public understanding of the SDGs and...
/dk/atira/pure/subjectarea/asjc/2300/2306 name=Global and Planetary Change /dk/atira/pure/subjectarea/asjc/1100/1106 name=Food Science /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2300/2303 name=Ecology /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/3300/3322 name=Urban Studies /dk/atira/pure/subjectarea/asjc/2300/2309 name=Nature and Landscape Conservation /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis
Gábor Kökény, Laurent Calvier, Ekaterina Legchenko, Philippe Chouvarine, Miklós M Mózes, Georg Hansmann
Dec 16, 2019
PURPOSE OF REVIEW: Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and apoptosis, pulmonary arterial smooth muscle cell (PASMC) proliferation, inflammation...
Turning the Mre11/Rad50 DNA repair complex on its head
The bacterial SbcC/SbcD DNA repair proteins were identified over a quarter of a century ago. Following the subsequent identification of the homologous Mre11/Rad50 complex in the eukaryotes and archaea, it has become clear that...
DNA Repair Mre11–Rad50 SMC Archaea Chromosomes Acid Anhydride Hydrolases Adenosine Triphosphatases Adenosine Triphosphate Archaeal Proteins Bacterial Proteins Cell Cycle DNA DNA Breaks Double-Stranded DNA Repair DNA-Binding Proteins Deoxyribonucleases Endodeoxyribonucleases Escherichia coli Proteins Exodeoxyribonucleases Exonucleases Humans Hydrolysis MRE11 Homologue Protein Mutation Protein Binding Protein Conformation Zinc
Neuroimaging in schizophrenia
Over the last five decades, a large body of evidence has accrued for structural and metabolic brain alterations in schizophrenia. Here we provide an overview of these findings, focusing on measures that have traditionally been...
An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank.
Ekaterina Yonova-Doing, Claudia Calabrese, Aurora Gomez-Duran, Katherine Schon, Wei Wei, Savita Karthikeyan, Patrick F Chinnery, Joanna MM Howson
Apr 21, 2021
Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly due to a lack of genotype calling and quality-control procedures. Developing an at-scale workflow for mtDNA variant analyses, we show...
Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs
Lewis H Mervin, Ekaterina Mitricheva, Nikos K Logothetis, Angelo Bifone, Andreas Bender, Hamid R Noori
Apr 10, 2021
Functional magnetic resonance imaging (fMRI) is an extensively used method for the investigation of normal and pathological brain function. In particular, fMRI has been used to characterize spatiotemporal hemodynamic response to...
Potential of International EMail Projects in the Process of Teaching a Foreign Language in Secondary School
The purpose of the article is to identify the theoretical foundations of the implementation of E-Mail projects in the process of teaching foreign languages; to analyze the results of implemented E-Mail projects; to encourage the...
Published by: IGI Global Scientific Publishing
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Harm J Bogaard, Ekaterina Legchenko, Ketul R Chaudhary, Xiao-Qing Sun, Duncan J Stewart, Georg Hansmann
Nov 20, 2019
Translational research is essential to develop strategies for the treatment of pulmonary arterial hypertension (PAH) using animal models which reproduce the severity, the progressive nature and resistance to...
Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Ekaterina Morgunova, Yimeng Yin, Pratyush K Das, Arttu Jolma, Fangjie Zhu, Alexander Popov, You Xu, Lennart Nilsson, Jussi Taipale
Oct 10, 2018
Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of...
DNA recognition Biochemistry chemical biology enthalpy Entropy Epistasis human molecular biophysics structural biology Thermodynamics Transcription Factors CDX2 Transcription Factor DNA Entropy Homeodomain Proteins Humans Models Molecular Nucleic Acid Conformation Protein Binding Protein Conformation Substrate Specificity Thermodynamics
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension
Harm J Bogaard, Ekaterina Legchenko, Maximilian Ackermann, Mark P Kühnel, Danny D Jonigk, Ketul R Chaudhary, Xiaoqing Sun, Duncan J Stewart, Georg Hansmann
Dec 11, 2019
To the editor:
Kojonazarov et al. recently reported severe emphysema in the SU5416/Hypoxia (SuHx) rat model of pulmonary hypertension (1). The authors found that adult male Wistar Kyoto (WKY) rats had increased air-to-tissue...
Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement.
Ekaterina Smirnova, Andrew E Firth, W Allen Miller, Danièle Scheidecker, Véronique Brault, Catherine Reinbold, Aurélie M Rakotondrafara, Betty Y-W Chung, Véronique Ziegler-Graff
Jun 02, 2015
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna M M Howson, Michael Inouye, Martin Dichgans
Jan 27, 2020
Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring...
Strong Suppression of Thermal Conductivity in the Presence of Long Terminal Alkyl Chains in Low-Disorder Molecular Semiconductors.
Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension.
Franziska Diekmann, Philippe Chouvarine, Hannes Sallmon, Louisa Meyer-Kobbe, Moritz Kieslich, Brian D Plouffe, Shashi K Murthy, Ralf Lichtinghagen, Ekaterina Legchenko, Georg Hansmann
Oct 26, 2021
Pulmonary arterial hypertension (PAH) is a progressive condition with an unmet need for early diagnosis, better monitoring, and risk stratification. The receptor for advanced glycation end products (RAGE) is activated in...
RV hypertrophy biomarker Inflammation Proliferation pulmonary arterial hypertension soluble receptor for advanced glycation end products (sRAGE) vascular injury Adult Aged Aged 80 and over Biomarkers Case-Control Studies Female Germany Humans Male Middle Aged Prognosis pulmonary arterial hypertension Receptor for Advanced Glycation End Products Sensitivity and Specificity Solubility Young Adult
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