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Results: 841
A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells.
Stephanie Chrysanthou, Claire E Senner, Laura Woods, Elena Fineberg, Hanneke Okkenhaug, Sarah Burge, Vicente Perez-Garcia, Myriam Hemberger
Jun 20, 2019
The ten-eleven translocation (TET) proteins are well known for their role in maintaining naive pluripotency of embryonic stem cells. Here, we demonstrate that, jointly, TET1 and TET2 also safeguard the self-renewal potential of...
TET proteins Cell Cycle DIFFERENTIATION endoreduplication Mitosis self-renewal trophoblast giant cells trophoblast stem cells Animals Cell Cycle Cell Line Cell Nucleus Shape Centrosome Cyclin B1 endoreduplication Epithelial Cells Epithelial-Mesenchymal Transition Gene Expression Regulation Gene Knockout Techniques Humans Polyploidy Protein Stability Proto-Oncogene Proteins Stem Cells Trophoblasts
Facing the "new normal"
Naomi A Fineberg, Luca Pellegrini, David Wellsted, Natalie Hall, Ornella Corazza, Valentina Giorgetti, Dorotea Cicconcelli, Elena Theofanous, Nick Sireau, David Adam, Samuel R Chamberlain, Keith R Laws
Aug 16, 2021
BACKGROUND: Re-establishing societal norms in the wake of the COVID-19 pandemic will be important for restoring public mental health and psychosocial wellbeing as well as economic recovery. We investigated the impact on...
Influence of Leadership Potential on the Effectiveness of Managerial Change
The current article puts forward the following hypothesis: leadership potential is the key to the effectiveness of changes taking place within business structures to ensure their functioning in the markets. In this context, the...
Published by: IGI Global Scientific Publishing
The Relevance of Immigrant Teachers' Experiences to Developing Professional Identity during a Teacher Requalification Program in Norway
As a result of increasing immigration to Norway and other European countries, many higher education institutions see a need to customize their educational programs or establish requalification programs for immigrants with...
Published by: IGI Global Scientific Publishing
Moodle Learning System as an Effective Tool for Implementing the Innovation Policy of the University
The current study examines Moodle learning management system as an effective tool for implementing the innovation policy of the university. For this, the following methods are employed: (1) monitoring of the Best Global...
Published by: IGI Global Scientific Publishing
Dr. Daniel F. Mahony Selected as President of Winthrop University
Winthrop University
Jan 01, 0001
Mahony will begin his duties on July 1, 2015. The President's House will be home to Mahony, his wife Laura and their two children, Gavin, 15, and Elena, 12. Dr. Daniel F. Mahony, dean of the College of Education, Health and...
Published by: Winthrop University
Winthrop to Host Variety of Events During Annual Come-See-Me Festival
Winthrop University
Jan 01, 0001
Several Winthrop University events are part of this year's festival, including the popular Teddy Bear Tea Party which will be hosted by First Lady Laura Mahony and daughter Elena. From dance showcases and plays to athletics and...
Published by: Winthrop University
Effective Use of Rubrics in Student Evaluation
This chapter clarifies first a number of concepts such as evaluation, traditional evaluation methods, alternative evaluation methods, process-centered evaluation, and evaluation of student progress and portfolios as an...
classroom management Education Learning Assessment and Measurement Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Effectiveness of Remote Interventions to Improve Medication Adherence in Patients after Stroke
Background
Stroke affects more than 30 million people every year, but only two-thirds of patients comply with prescribed medication, leading to high stroke recurrence rates. Digital technologies can facilitate...
University Students' Foreign Language Learning Behaviours in the Online Environment
Given that the COVID-19 pandemic has strongly impacted students' learning experiences, the present research aims to reveal some of the challenges brought by the online foreign language classes in higher education and to show a...
Sustainable Development Education Curriculum Development and Instructional Design Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Altered cognitive response to serotonin challenge as a candidate endophenotype for obsessive-compulsive disorder.
decision-making Endophenotypes Gambling Obsessive-Compulsive Disorder Risk adjustment Adolescent Adult Citalopram Cognition Cross-Over Studies Decision Making Double-Blind Method Endophenotypes Female Gambling Humans Male Middle Aged Obsessive-Compulsive Disorder Psychomotor Performance Risk Adjustment Serotonin Selective Serotonin Reuptake Inhibitors Young Adult
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder
Jonathan W Kanen, Karen D Ersche, Naomi A Fineberg, Trevor W Robbins, Rudolf N Cardinal
Jul 08, 2019
Addiction Amisulpride Compulsivity Computational modelling Dopamine Obsessive-Compulsive Disorder Pramipexole reinforcement learning Reversal Learning Stimulant use disorder Adult Central Nervous System Stimulants Cognition Dopamine Agonists Dopamine Antagonists Dopamine D2 Receptor Antagonists Double-Blind Method Female Humans Male Middle Aged Models Neurological Obsessive-Compulsive Disorder Receptors Dopamine D2 Receptors Dopamine D3 Reinforcement psychology Reversal Learning Reward Substance-Related Disorders Young Adult
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder
Jonathan W. Kanen, Karen D. Ersche, Naomi A. Fineberg, Trevor W. Robbins, Rudolf N. Cardinal
Jul 19, 2020
Abstract: Rationale: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using...
Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder.
Annemieke M Apergis-Schoute, Bastiaan Bijleveld, Claire M Gillan, Naomi A Fineberg, Barbara J Sahakian, Trevor W Robbins
Jan 03, 2020
Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive functioning....
Avoid jumping to conclusions under uncertainty in Obsessive Compulsive Disorder
Sharon Morein-Zamir, Sonia Shapher, Julia Gasull-Camos, Naomi A. Fineberg, Trevor W. Robbins
Jan 15, 2020
High levels of intolerance of uncertainty (IU) could contribute to abnormal decision making in uncertain situations. Patients with Obsessive Compulsive Disorder (OCD) often report high IU, indecisiveness and the need to seek...
The Interplay Between Career Adaptability and Foreign Language Skills in an Unstable Labor Market
Career adaptability is a soft skill that allows people to cope with professional tasks in an unpredictable labor market. Today's global labor market also requires language skills to facilitate employees' collaboration across...
Published by: IGI Global Scientific Publishing
Avoid jumping to conclusions under uncertainty in Obsessive Compulsive Disorder.
Sharon Morein-Zamir, Sonia Shapher, Julia Gasull-Camos, Naomi A Fineberg, Trevor W Robbins
Feb 15, 2020
High levels of intolerance of uncertainty (IU) could contribute to abnormal decision making in uncertain situations. Patients with Obsessive Compulsive Disorder (OCD) often report high IU, indecisiveness and the need to seek...
Published by: PLOS ONE
Individual obsessive-compulsive traits are associated with poorer adjustment to the easing of COVID-19 restrictions.
BACKGROUND: As COVID-19 restrictions ease, the public are expected to relinquish previously enforced safety behaviors and resume a more normal lifestyle. Despite these aims, our recent survey of 438 adults from the general...
Cognitive dysfunction in body dysmorphic disorder
Affective processing body dysmorphic disorder cognitive deficits cognitive inflexibility neurobiological Obsessive compulsive disorder Response inhibition Adult Attention Body Dysmorphic Disorders Case-Control Studies Cognitive Dysfunction Decision Making Female Humans INHIBITION Psychological Male Middle Aged Models Neurological Models Psychological Neurobiology Neuropsychological Tests Reaction Time Young Adult
Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder.
Annemieke M Apergis-Schoute, Bastiaan Bijleveld, Claire M Gillan, Naomi A Fineberg, Barbara J Sahakian, Trevor W Robbins
Dec 20, 2019
Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive functioning....
Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation.
Matilde M Vaghi, Rudolf N Cardinal, Annemieke M Apergis-Schoute, Naomi A Fineberg, Akeem Sule, Trevor W Robbins
Dec 21, 2018
A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD.
Marjan Biria, Fiona-Xiaofei Huang, Yulia Worbe, Naomi A Fineberg, Trevor W Robbins, Emilio Fernandez-Egea
Jun 17, 2019
Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K White, Elizabeth Tuck, Edward J Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M Busch-Nentwich, Antonella Galli, James C Smith, Elizabeth Robertson, David J Adams, Wolfgang J Weninger, Timothy Mohun, Myriam Hemberger
Jun 20, 2018
Large-scale phenotyping efforts have demonstrated that approximately 25-30% of mouse gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused on the embryo and not the placenta, despite the...
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