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Results: 148
Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
Md Saiful Islam, Michael A McDonough, Rasheduzzaman Chowdhury, Joseph Gault, Amjad Khan, Elisabete Pires, Christopher J Schofield
Jun 26, 2020
2-oxoglutarate and iron dependent dioxygenase C-5 hydroxylysine JMJD6 JmjC domain-containing protein 6 RNA Splicing X-ray crystallography dioxygenase enzyme catalysis enzyme structure hydroxylase hydroxylysine (Hyl) Hypoxia metalloenzyme Substrate Specificity Catalysis Crystallography X-Ray Estrogen Receptor alpha Humans Hydroxylation Jumonji Domain-Containing Histone Demethylases Kinetics Lysine Protein Conformation Substrate Specificity
Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct.
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P Roberto da Costa, Dariusz J Skarzynski, Graça Ferreira-Dias
Jun 28, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and...
Converting an Allocentric Goal Direction into an Egocentric Steering Signal in Drosophila
Peter Mussells Pires
Jan 01, 0001
Neuronal signals relevant for spatial navigation have been described in many species, however, a circuit-level understanding of how such signals interact to guide behaviour is lacking. In this thesis, I characterize a neuronal...
Published by: Rockefeller University
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Malgorzata Cyranka, Anna Veprik, Eleanor J McKay, Nienke van Loon, Amber Thijsse, Luke Cotter, Nisha Hare, Affan Saibudeen, Swathi Lingam, Elisabete Pires, Pierre Larraufie, Frank Reimann, Fiona Gribble, Michelle Stewart, Elizabeth Bentley, Pamela Lear, James McCullagh, James Cantley, Roger D Cox, Heidi de Wet
Jan 23, 2020
OBJECTIVE: A previous genome-wide association study linked overexpression of an ATP-binding cassette transporter, ABCC5, in humans with a susceptibility to developing type 2 diabetes with age. Specifically, ABCC5 gene...
DUET
Cancer genome and other sequencing initiatives are generating extensive data on non-synonymous single nucleotide polymorphisms (nsSNPs) in human and other genomes. In order to understand the impacts of nsSNPs on the structure...
mCSM–NA
Binding Sites DNA DNA-Binding Proteins Humans Internet Machine Learning Models Molecular Models Statistical Mutation Missense Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Stability RNA-Binding Proteins Reverse Genetics Software Thermodynamics
dendPoint
Abstract: Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs....
The road to recovery
The COVID-19 pandemic has resulted in cities implementing lockdown measures, causing unprecedented disruption (e.g. school/shop/office closures) to urban life often extending over months. With the spread of COVID-19 now being...
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
DynaMut
Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based...
mCSM-PPI2
Benchmarking Binding Sites Crystallography X-Ray Datasets as Topic Humans Internet Machine Learning Mutation Missense Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Interaction Mapping Proteins Software Thermodynamics
The impact of diagnostic microbiology on de-escalation of antimicrobial therapy in hospitalised adults
William L. Hamilton, Sacha-Marie Pires, Samantha Lippett, Vikesh Gudka, Elizabeth L. A. Cross, Martin J. Llewelyn
Jun 06, 2020
Abstract: Background: Minimising antimicrobial overuse is needed to limit antimicrobial resistance. There is little evidence on how often microbiological testing informs antimicrobial de-escalation (e.g. stopping, shortening...
In silico functional dissection of saturation mutagenesis
Carcinoma Renal Cell Computer Simulation DNA DNA Mutational Analysis DNA-Binding Proteins Humans Kidney Neoplasms Mutagenesis Mutation Phenotype Protein Binding Protein Interaction Maps Protein Stability RNA Nucleotidyltransferases Regression Analysis Risk Factors Saccharomyces cerevisiae Proteins Transcription Factors von Hippel-Lindau Disease
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