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Regulation of host and viral promoters during human cytomegalovirus latency via US28 and CTCF.
Viral latency is an active process during which the host cell environment is optimized for latent carriage and reactivation. This requires control of both viral and host gene promoters and enhancers often at the level of...
CTCF Chromatin Cytomegalovirus latency viral gene expression virus-host interactions CCCTC-Binding Factor Calgranulin A Calgranulin B Cytomegalovirus Cytomegalovirus Infections Enhancer Elements Genetic Gene Expression Regulation Genes Immediate-Early Host-Pathogen Interactions Humans Monocytes Promoter Regions Genetic Receptors Chemokine Viral Proteins Virus Latency
Interview with Miriam Elizabeth McLaurin Gulledge
Miriam McLaurin Gulledge
Jan 01, 0001
Interview with Miriam Elizabeth McLaurin Gulledge, 2012 South Carolina Mother of the Year.
Published by: Winthrop University
Program for the Stage Production Ring Around Elizabeth
Curtain Club
Jan 01, 0001
This four-page program details the Curtain Club of Ursinus College's production of Ring Around Elizabeth, held December 12, 1942 in Thompson-Gay Gymnasium. It includes information about the directors, cast, production of the...
Charl Armstrong Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency.
Elizabeth G Elder, Benjamin A Krishna, James Williamson, Eleanor Y Lim, Emma Poole, George X Sedikides, Mark Wills, Christine M O'Connor, Paul J Lehner, John Sinclair
Jan 06, 2020
Human cytomegalovirus (HCMV) latency is an active process which remodels the latently infected cell to optimize latent carriage and reactivation. This is achieved, in part, through the expression of viral genes, including the...
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.
Timo WM De Groof, Elizabeth G Elder, Eleanor Y Lim, Raimond Heukers, Nick D Bergkamp, Ian J Groves, Mark Wills, John H Sinclair, Martine J Smit
Jul 23, 2021
Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.
Timo W M De Groof, Elizabeth G Elder, Eleanor Y Lim, Raimond Heukers, Nick D Bergkamp, Ian J Groves, Mark Wills, John H Sinclair, Martine J Smit
Aug 26, 2021
T-Lymphocytes Cytotoxic Monocytes Cells Cultured Humans Cytomegalovirus Cytomegalovirus Infections Receptors Chemokine Viral Proteins Virus Latency Virus Activation Signal Transduction Gene Expression Genes Immediate-Early Single-Domain Antibodies Lipopolysaccharide Receptors
Published by: Nature Communications
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice.
Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goedert
Feb 12, 2023
Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between...
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency.
Elizabeth G Elder, Benjamin A Krishna, James Williamson, Eleanor Y Lim, Emma Poole, George X Sedikides, Mark Wills, Christine M O'Connor, Paul J Lehner, John Sinclair
Nov 12, 2019
IFI16 US28 Cytomegalovirus interferon response viral latency Cell Differentiation Cell Line Cytomegalovirus Cytomegalovirus Infections Down-Regulation Gene Expression Gene Expression Regulation Viral HEK293 Cells Humans Interferons Monocytes Myeloid Cells NF-kappa B Promoter Regions Genetic Proteomics Receptors G-Protein-Coupled THP-1 Cells Viral Proteins Virus Activation Virus Latency
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Jul 28, 2021
Abstract: Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
Cross-Currents
Isobel Maddison
Nov 05, 2018
When Elizabeth von Arnim's novel 'Introduction to Sally' appeared in 1926, the critical response was divided. Dame Ethel Smyth may have told von Arnim the book was her 'masterpiece' but some were less convinced; the reviewer in...
Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing.
Elizabeth Elder, Benjamin Krishna, James Williamson, Yusuf Aslam, Neda Farahi, Alexander Wood, Veronika Romashova, Kate Roche, Eain Murphy, Edwin Chilvers, Paul J Lehner, John Sinclair, Emma Poole
Feb 01, 2019
One site of latency of human cytomegalovirus (HCMV) in vivo is in undifferentiated cells of the myeloid lineage. Although latently infected cells are known to evade host T cell responses by suppression of T cell effector...
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