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Results: 64
The integrated stress response regulates BMP signalling through effects on translation.
Elke Malzer, Caia S Dominicus, Joseph Chambers, Jennifer Dickens, Souradip Mookerjee, Stefan Marciniak
May 24, 2018
Background: Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and...
Pulmonary endoplasmic reticulum stress-scars, smoke, and suffocation.
Protein misfolding within the endoplasmic reticulum (ER stress) can be a cause or consequence of pulmonary disease. Mutation of proteins restricted to the alveolar type II pneumocyte can lead to inherited forms of pulmonary...
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Sally E Thomas, Elke Malzer, Adriana Ordóñez, Lucy E Dalton, Emily FA van T Wout, Elizabeth Liniker, Damian C Crowther, David A Lomas, Stefan J Marciniak
Feb 12, 2019
Cell cycle checkpoints ensure that proliferation occurs only under permissive conditions, but their role in linking nutrient availability to cell division is incompletely understood. Protein folding within the endoplasmic...
Animals Cell Cycle Cell Line Cell Line Tumor Cell Proliferation Cell Separation Drosophila melanogaster Endoplasmic Reticulum Flow Cytometry Gene Expression Regulation Genes p53 HEK293 Cells HeLa Cells Humans Plasmids Protein Biosynthesis Protein Phosphatase 1 RNA Interference Tumor Suppressor Protein p53
Addressing the need for standardization of test methods for self-healing concrete
Tim Van Mullem, Giovanni Anglani, Marta Dudek, Hanne Vanoutrive, Girts Bumanis, Chrysoula Litina, Arkadiusz Kwiecień, Abir Al-Tabbaa, Diana Bajare, Teresa Stryszewska, Robby Caspeele, Kim Van Tittelboom, Tulliani Jean-Marc, Elke Gruyaert, Paola Antonaci, Nele De Belie
Jul 21, 2021
Development and commercialization of self-healing concrete is hampered due to a lack of standardized test methods. Six inter-laboratory testing programs are being executed by the EU COST action SARCOS, each focusing on test...
The Ursinus Weekly, April 14, 1952
Sarah Canan, Richard P. Richter, Evelyn Scharf, Robert E. Armstrong, Ted Wenner, William Lukens
Jan 01, 0001
MSGA plans for evaluation of professors Alumni to hear Dr. Furbay speak Language table meets Sophs, freshmen draw up petitions; Deadline April 16 Plans made to stop cheating Library acquires new books Operetta "Sari"...
Ursinus College Collegeville Pennsylvania newspaper student government John H. Furbay cheating LIBRARY French Club Cultural Olympics Music Club YMCA YWCA Pi Gamma Mu Arnold Ulbricht International Relations Club German Club Jean Shepherd G. Sieber Pancoast baseball Ed Dawkins wrestling Bob Swett Basketball Gladys Hoagland Garlock Vermont cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Dual-energy computed tomography in acute ischemic stroke
Stephanie Mangesius, Tanja Janjic, Ruth Steiger, Lukas Haider, Rafael Rehwald, Michael Knoflach, Gerlig Widmann, Elke Gizewski, Astrid Grams
May 20, 2021
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan J Marciniak
May 26, 2015
CReP D. melanogaster GADD34 PPP1R15A PPP1R15B actin Biochemistry Cell Biology human integrated stress response MOUSE Actins Amino Acid Sequence Animals Conserved Sequence Depsipeptides Drosophila melanogaster Eukaryotic Initiation Factor-2 HEK293 Cells Humans Mice Molecular Sequence Data Phosphorylation Protein Binding Protein Phosphatase 1 Stress Physiological
New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms.
Stefan J Marciniak, Adriana Ordóñez, Jennifer A Dickens, Joseph E Chambers, Vruti Patel, Caia S Dominicus, Elke Malzer
Jun 04, 2019
Alpha-1 antitrypsin deficiency is predominantly caused by point mutations that alter the protein's folding. These mutations fall into two broad categories: those that destabilize the protein dramatically and lead to its...
endoplasmic reticulum overload endoplasmic reticulum overload response Endoplasmic reticulum stress serpin Unfolded Protein Response Endoplasmic Reticulum Endoplasmic reticulum stress Humans Mutation NF-kappa B Signal Transduction Unfolded Protein Response alpha 1-Antitrypsin alpha 1-Antitrypsin Deficiency
Mitochondrial dysfunction in liver failure requiring transplantation.
Maria Lane, Veronika Boczonadi, Sahar Bachtari, Aurora Gomez-Duran, Thorsten Langer, Alexandra Griffiths, Stephanie Kleinle, Christine Dineiger, Angela Abicht, Elke Holinski-Feder, Ulrike Schara, Patrick Gerner, Rita Horvath
Mar 07, 2019
Liver failure is a heterogeneous condition which may be fatal and the primary cause is frequently unknown. We investigated mitochondrial oxidative phosphorylation in patients undergoing liver transplantation. We studied 45...
Liver Mitochondria Humans Liver Neoplasms Biliary Atresia Liver Failure Liver Cirrhosis Mitochondrial Diseases Electron Transport Complex IV DNA Mitochondrial Liver Transplantation Electron Transport Oxidative Phosphorylation Adolescent Adult Middle Aged Child Child Preschool Infant Female Male Young Adult
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.
Jennifer A Dickens, Adriana Ordóñez, Joseph E Chambers, Alison J Beckett, Vruti Patel, Elke Malzer, Caia S Dominicus, Jayson Bradley, Andrew A Peden, Ian A Prior, David A Lomas, Stefan J Marciniak
Nov 16, 2016
Parents' views about healthcare professionals having real-time remote access to their young child's diabetes data
Barbara Kimbell, David Rankin, Ruth I Hart, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Elke Fröhlich-Reiterer, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Ulrike Schierloh, Ajay Thankamony, Julia Ware, Roman Hovorka, Julia Lawton, KidsAP Consortium
May 26, 2022
Respiratory chain deficiency in nonmitochondrial disease.
Angela Pyle, Helen J Nightingale, Helen Griffin, Angela Abicht, Janbernd Kirschner, Ivo Baric, Mario Cuk, Konstantinos Douroudis, Lea Feder, Markus Kratz, Birgit Czermin, Stephanie Kleinle, Mauro Santibanez-Koref, Veronika Karcagi, Elke Holinski-Feder, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
OBJECTIVE: In this study, we report 5 patients with heterogeneous phenotypes and biochemical evidence of respiratory chain (RC) deficiency; however, the molecular diagnosis is not mitochondrial disease. METHODS: The reported...
Epithelial calcineurin controls microbiota-dependent intestinal tumor development.
Kenneth Peuker, Stefanie Muff, Jun Wang, Sven Künzel, Esther Bosse, Yvonne Zeissig, Giuseppina Luzzi, Marijana Basic, Anne Strigli, Andrea Ulbricht, Arthur Kaser, Alexander Arlt, Triantafyllos Chavakis, Gijs R van den Brink, Clemens Schafmayer, Jan-Hendrik Egberts, Thomas Becker, Marco E Bianchi, André Bleich, Christoph Röcken, Jochen Hampe, Stefan Schreiber, John F Baines, Richard S Blumberg, Sebastian Zeissig
Aug 09, 2016
Animals Blotting Western Calcineurin Cell Proliferation Cell Survival Colorectal Neoplasms Disease Models Animal Electrophoretic Mobility Shift Assay Epithelial Cells Fecal Microbiota Transplantation Flow Cytometry Gastrointestinal Microbiome Genes APC HCT116 Cells HT29 Cells Humans Immunohistochemistry In Situ Hybridization Fluorescence Intestinal Mucosa Intestinal Neoplasms Intestines Mice NFATC Transcription Factors Neoplastic Stem Cells Organoids Prognosis RNA Ribosomal 16S Reverse Transcriptase Polymerase Chain Reaction Tissue Array Analysis
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence SC Lok, Jeremy A Pike, Jennifer Mueller-Winkler, Thomas W Dennison, John R Ferdinand, Cameron JM Burnett, Juan C Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor LJ Tybulewicz, Antal Rot, Anja E Hauser, Menna R Clatworthy, Kai-Michael Toellner
May 09, 2022
Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory...
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
Parents' experiences of using remote monitoring technology to manage type 1 diabetes in very young children during a clinical trial
Ruth I Hart, Barbara Kimbell, David Rankin, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Carine de Beaufort, Elke Fröhlich-Reiterer, Julia Ware, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Ajay Thankamony, Roman Hovorka, Julia Lawton, KidsAP Consortium
Mar 31, 2022
Closed-loop system Parents qualitative research remote monitoring sensor-augmented pump therapy type 1 diabetes young children Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Clinical Trials as Topic Diabetes mellitus Type 1 Humans Infant Insulin Insulin Infusion Systems Parents Remote Sensing Technology
Evaluation of a worldwide EQA scheme for complex clonality analysis of clinical lymphoproliferative cases demonstrates a learning effect.
Cleo Keppens, Elke Boone, Paula Gameiro, Véronique Tack, Elisabeth Moreau, Elizabeth Hodges, Paul Evans, Monika Brüggemann, Ian Carter, Dido Lenze, Maria Eugenia Sarasquete, Markus Möbs, Hongxiang Liu, Elisabeth MC Dequeker, Patricia JTA Groenen
Aug 14, 2021
Clonality analysis of immunoglobulin (IG) or T-cell receptor (TR) gene rearrangements is routine practice to assist diagnosis of lymphoid malignancies. Participation in external quality assessment (EQA) aids laboratories in...
Clonality analysis external quality assessment IG rearrangements TCR rearrangements Gene Rearrangement Genes Immunoglobulin Genes T-Cell Receptor Humans Laboratory Proficiency Testing Lymphoproliferative Disorders Molecular Diagnostic Techniques Observer Variation Polymerase Chain Reaction Predictive Value of Tests Quality Assurance Health Care Quality Control Reproducibility of Results
Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.
Benoit D Roussel, Timothy M Newton, Elke Malzer, Nikol Simecek, Imran Haq, Sally E Thomas, Marian L Burr, Paul J Lehner, Damian C Crowther, Stefan J Marciniak, David A Lomas
May 18, 2018
Mutants of neuroserpin are retained as polymers within the endoplasmic reticulum (ER) of neurones to cause the autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. The cellular...
Animals Cells Cultured Cholesterol Disease Models Animal Drosophila melanogaster Endoplasmic Reticulum Epilepsies Myoclonic HeLa Cells Heredodegenerative Disorders Nervous System Humans Mice Mutant Proteins Neurons Neuropeptides Polymers Protein Unfolding Serpins Signal Transduction Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Unfolded Protein Response
A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis.
Elke de Boer, Charlotte W Ockeloen, Leslie Matalonga, Rita Horvath, Solve-RD SNV-indel working group, Richard J Rodenburg, Marieke JH Coenen, Mirian Janssen, Dylan Henssen, Christian Gilissen, Wouter Steyaert, Ida Paramonov, Solve-RD-DITF-ITHACA, Aurélien Trimouille, Tjitske Kleefstra, Alain Verloes, Lisenka ELM Vissers
Sep 24, 2021
Nuclear factors involved in mitochondrial translation cause a subgroup of combined respiratory chain deficiency.
John P Kemp, Paul M Smith, Angela Pyle, Vivienne CM Neeve, Helen AL Tuppen, Ulrike Schara, Beril Talim, Haluk Topaloglu, Elke Holinski-Feder, Angela Abicht, Birgit Czermin, Hanns Lochmüller, Robert McFarland, Patrick F Chinnery, Zofia MA Chrzanowska-Lightowlers, Robert N Lightowlers, Robert W Taylor, Rita Horvath
Mar 07, 2019
Mutations in several mitochondrial DNA and nuclear genes involved in mitochondrial protein synthesis have recently been reported in combined respiratory chain deficiency, indicating a generalized defect in mitochondrial...
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence SC Lok, Jeremy A Pike, Jennifer Mueller-Winkler, Thomas W Dennison, John R Ferdinand, Cameron JM Burnett, Juan C Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor LJ Tybulewicz, Antal Rot, Anja E Hauser, Menna R Clatworthy, Kai-Michael Toellner
Jun 07, 2022
Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory...
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi
Oct 18, 2022
Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study)
Julia Fuchs, Janet M Allen, Charlotte K Boughton, Malgorzata E Wilinska, Ajay Thankamony, Carine de Beaufort, Fiona Campbell, James Yong, Elke Froehlich-Reiterer, Julia K Mader, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Martin Tauschmann, Korey Hood, Barbara Kimbell, Julia Lawton, Stephane Roze, Judy Sibayan, Nathan Cohen, Roman Hovorka, KidsAP Consortium
Jan 12, 2021
INTRODUCTION: Diabetes management in very young children remains challenging. Glycaemic targets are achieved at the expense of high parental diabetes management burden and frequent hypoglycaemia, impacting quality of life for...
DIABETES & ENDOCRINOLOGY general diabetes paediatric endocrinology Paediatrics Austria Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Humans Hypoglycemic Agents Infant Insulin Insulin Infusion Systems Luxembourg Multicenter Studies as Topic Quality of life Randomized Controlled Trials as Topic Treatment Outcome
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