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Results: 46
ERα-36 regulates progesterone receptor activity in breast cancer.
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
May 20, 2021
BACKGROUND: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer...
ERα-36 regulates progesterone receptor activity in breast cancer
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
Jun 06, 2020
Abstract: Background: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of...
Local Structure and Dynamics in Methylammonium, Formamidinium, and Cesium Tin(II) Mixed-Halide Perovskites from 119Sn Solid-State NMR.
Dominik J Kubicki, Daniel Prochowicz, Elodie Salager, Aydar Rakhmatullin, Clare P Grey, Lyndon Emsley, Samuel D Stranks
Apr 06, 2020
Organic-inorganic tin(II) halide perovskites have emerged as promising alternatives to lead halide perovskites in optoelectronic applications. While they suffer from considerably poorer performance and stability in comparison to...
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu-Wai-Man, Pascal Reynier, Timothy Wai
Jun 21, 2021
Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts cristae...
Published by: EMBO molecular medicine
GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.
Borbala Mifsud, Inigo Martincorena, Elodie Darbo, Robert Sugar, Stefan Schoenfelder, Peter Fraser, Nicholas M Luscombe
Jul 15, 2019
Hi-C is one of the main methods for investigating spatial co-localisation of DNA in the nucleus. However, the raw sequencing data obtained from Hi-C experiments suffer from large biases and spurious contacts, making it difficult...
Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells.
Elodie J Siney, Alexander Holden, Elizabeth Casselden, Harry Bulstrode, Gareth J Thomas, Sandrine Willaime-Morawek
Apr 12, 2019
Glioblastoma is the most common form of primary malignant brain tumour. These tumours are highly proliferative and infiltrative resulting in a median patient survival of only 14 months from diagnosis. The current treatment...
cancer stem cell Cell Differentiation cell migration Disintegrin Extracellular Matrix glioma ADAM10 Protein ADAM17 Protein Adult Aged Cell Death Cell Differentiation Cell Movement Extracellular Matrix Female Fibronectins Glioblastoma Humans Integrin alpha5beta1 Male Matrix Metalloproteinase Inhibitors Middle Aged Neoplastic Stem Cells Neural Stem Cells Spheroids Cellular
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.
Elodie Persyn, Ken B Hanscombe, Joanna MM Howson, Cathryn M Lewis, Matthew Traylor, Hugh S Markus
Mar 30, 2020
Alginates along the filament of the brown alga Ectocarpus help cells cope with stress.
Hervé Rabillé, Thomas A Torode, Benoit Tesson, Aude Le Bail, Bernard Billoud, Elodie Rolland, Sophie Le Panse, Murielle Jam, Bénédicte Charrier
Sep 09, 2020
Ectocarpus is a filamentous brown alga, which cell wall is composed mainly of alginates and fucans (80%), two non-crystalline polysaccharide classes. Alginates are linear chains of epimers of 1,4-linked uronic acids...
Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers
Pierre Vande Perre, Daniel Toledano, Carole Corsini, Elsa Escriba, Marine Laporte, Helena Bertet, Kevin Yauy, Alain Toledano, Virginie Galibert, Karen Baudry, Lucie Clotet, Elodie Million, Marie-Christine Picot, David Geneviève, Pascal Pujol
Sep 26, 2019
BRCA1 BRCA2 general practitioners genetic screening Hereditary Breast and Ovarian Cancer Syndrome Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Female general practitioners Genetic Carrier Screening Genetic Counseling Health Knowledge Attitudes practice Humans Middle Aged Referral and Consultation
Mapping the cooperativity pathways in spin crossover complexes.
Matthew G Reeves, Elodie Tailleur, Peter A Wood, Mathieu Marchivie, Guillaume Chastanet, Philippe Guionneau, Simon Parsons
Jul 28, 2021
Crystal packing energy calculations are applied to the [Fe(PM-L)2(NCS)2] family of spin crossover (SCO) complexes (PM-L = 4-substituted derivatives of the N-(2-pyridylmethylene)-4-aminobiphenyl ligand) with the aim of relating...
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu-Wai-Man, Pascal Reynier, Timothy Wai
Jun 28, 2021
Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts cristae...
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts
Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu‐Wai‐Man, Pascal Reynier, Timothy Wai
May 20, 2021
Abstract: Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts...
EMBO16 EMBO27 EMBO57 article ARTICLES Genetic modifiers high‐throughput screening Mitochondrial Dynamics OPA1 Phospholipid Metabolism
Published by: EMBO molecular medicine
Female sexual behavior in mice is controlled by kisspeptin neurons.
Vincent Hellier, Olivier Brock, Michael Candlish, Elodie Desroziers, Mari Aoki, Christian Mayer, Richard Piet, Allan Herbison, William Henry Colledge, Vincent Prévot, Ulrich Boehm, Julie Bakker
Sep 08, 2018
Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural...
Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.
Buhe Nashun, Peter WS Hill, Sebastien A Smallwood, Gopuraja Dharmalingam, Rachel Amouroux, Stephen J Clark, Vineet Sharma, Elodie Ndjetehe, Pawel Pelczar, Richard J Festenstein, Gavin Kelsey, Petra Hajkova
Jun 24, 2019
The integrity of chromatin, which provides a dynamic template for all DNA-related processes in eukaryotes, is maintained through replication-dependent and -independent assembly pathways. To address the role of histone deposition...
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants
Elodie Persyn, Ken B. Hanscombe, Joanna M. M. Howson, Cathryn M. Lewis, Matthew Traylor, Hugh S. Markus
May 01, 2021
Abstract: Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and...
A portable extensional rheometer for measuring the viscoelasticity of pitcher plant and other sticky liquids in the field.
Catherine Collett, Alia Ardron, Ulrike Bauer, Gary Chapman, Elodie Chaudan, Bart Hallmark, Lee Pratt, Maria Dolores Torres-Perez, D Ian Wilson
May 12, 2015
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Sep 13, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...
The autophagy protein ATG9A promotes HIV-1 infectivity.
Elodie Mailler, Abdul A Waheed, Sang-Yoon Park, David C Gershlick, Eric O Freed, Juan S Bonifacino
Jul 02, 2020
BACKGROUND: Nef is a multifunctional accessory protein encoded by HIV-1, HIV-2 and SIV that plays critical roles in viral pathogenesis, contributing to viral replication, assembly, budding, infectivity and immune evasion...
Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages.
Stefan Schoenfelder, Borbala Mifsud, Claire E Senner, Christopher D Todd, Stephanie Chrysanthou, Elodie Darbo, Myriam Hemberger, Miguel R Branco
Jul 15, 2019
The establishment of the embryonic and trophoblast lineages is a developmental decision underpinned by dramatic differences in the epigenetic landscape of the two compartments. However, it remains unknown how epigenetic...
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Oct 15, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...
Genetically personalised organ-specific metabolic models in health and disease
PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.
Alison Yeomans, Elizabeth Lemm, Sarah Wilmore, Breeze E Cavell, Beatriz Valle-Argos, Sergey Krysov, Marina Sanchez Hidalgo, Elodie Leonard, Anne E Willis, Francesco Forconi, Freda K Stevenson, Andrew J Steele, Mark J Coldwell, Graham Packham
Aug 19, 2021
Increased mRNA translation drives carcinogenesis and is an attractive target for the development of new anti-cancer drugs. In this work, we investigated effects of phenethylisothiocyanate (PEITC), a phytochemical with...
Myc eIF2α mRNA translation mTORC1 phenethylisothiocyanate Antibodies Anti-Idiotypic Cell Line Tumor Cell Survival Dose-Response Relationship Drug Eukaryotic Initiation Factor-2 Gene Expression Regulation Leukemic Genes myc Humans Isothiocyanates Leukemia Leukemia Lymphocytic Chronic B-Cell MCF-7 Cells Mechanistic Target of Rapamycin Complex 1 Phosphorylation Protein Biosynthesis RNA Messenger Receptors Antigen B-Cell Stress Physiological Transcription Genetic
Genetically personalised organ-specific metabolic models in health and disease
Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020.
Claude Flamand, Christelle Alves Sarmento, Antoine Enfissi, Sarah Bailly, Emmanuel Beillard, Mélanie Gaillet, Céline Michaud, Véronique Servas, Nathalie Clement, Anaïs Perilhou, Thierry Carage, Didier Musso, Jean-François Carod, Stéphanie Eustache, Céline Tourbillon, Elodie Boizon, Samantha James, Félix Djossou, Henrik Salje, Simon Cauchemez, Dominique Rousset
Dec 22, 2021
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