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Results: 439
One hundred years ago
Emilio Fernandez-Egea
Mar 28, 2019
A footpath in the Square de la Tour Saint-Jacques in Paris is named for the dancer Vaslav Nijinsky (1889–1950). It was in the nearby Théâtre du Châtelet that the ‘God of Dance’ astounded audiences and scandalized critics with...
Women Neuroscientist Disciples of Pío del Río-Hortega
Cristina Nombela, Emilio Fernández-Egea, Elena Giné, Yulia Worbe, Juan Del Río-Hortega Bereciartu, Fernando de Castro
May 24, 2021
Pio del Rio-Hortega was not only the discoverer of the microglia and oligodendroglia but also possibly the most prolific mentor of all Santiago Ramon y Cajal's disciples (Nobel awardee in Physiology or Medicine 1906 and...
Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition
Francesco Dal Santo, Isaac Jarratt-Barnham, Leticia González-Blanco, María Paz García-Portilla, Julio Bobes, Emilio Fernández-Egea
Jan 28, 2020
Multidimensional predictors of negative symptoms in antipsychotic-naive first-episode psychosis.
Alba Toll, Laura Blanco-Hinojo, Daniel Bergé, Xavier Duran, Irene Canosa, Teresa Legido, Federico Marmol, Víctor Pérez-Solà, Emilio Fernández-Egea, Anna Mané
Feb 20, 2022
BACKGROUND: Despite a large body of schizophrenia research, we still have no reliable predictors to guide treatment from illness onset. The present study aimed to identify baseline clinical or neurobiological factors - including...
Intra-individual variation of clozapine and norclozapine plasma levels in clinical practice.
INTRODUCTION: Clozapine plasma levels are useful to monitor drug compliance, and also to assess and to prevent some side effects. Recently, routine monitoring to all clozapine-treated patients has been proposed to prevent...
Early versus late risk factors for deficit and nondeficit schizophrenia.
Setareh Alabaf, Brian Kirkpatrick, Shanquan Chen, Rudolf N Cardinal, Emilio Fernandez-Egea
Apr 12, 2021
AIM: We examined whether timing of known risk factors for schizophrenia may influence the development of schizophrenia with primary negative symptoms. METHOD: This cross-sectional single-centre study in England used a clinical...
A Case Study of Clozapine and Cognition
George Savulich, Gisela Mezquida, Samuel Atkinson, Miguel bernardo, Emilio Fernandez-Egea
Mar 27, 2018
Cognitive dysfunction is a hallmark feature of schizophrenia, often presenting in patients with psychotic disorders since the first episode (1) or earlier (2). Antipsychotic medication is effective for treating the positive...
Tryptophan Depletion Promotes Habitual over Goal-Directed Control of Appetitive Responding in Humans.
5-HT goal-directed behavior inhibitory control Serotonin stimulus-response habit learning tryptophan depletion Adult Appetitive Behavior Conditioning Operant Executive Function Female Goals Habits Humans INHIBITION Psychological Male Psychological Tests Psychomotor Performance Serotonin Synaptic Transmission Tryptophan
Mechanisms Underlying Motivational Dysfunction in Schizophrenia.
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
An Early Developmental Marker of Deficit versus Nondeficit Schizophrenia.
Brian Kirkpatrick, Özlem Gürbüz Oflezer, Mehtap Delice Arslan, Gary Hack, Emilio Fernandez-Egea
Sep 16, 2019
People with schizophrenia and primary negative symptoms (deficit schizophrenia) differ from those without such symptoms (nondeficit schizophrenia) on risk factors, course of illness, other signs and symptoms, treatment response...
Network equilibration and first-principles liquid water.
Motivated by the very low diffusivity recently found in ab initio simulations of liquid water, we have studied its dependence with temperature, system size, and duration of the simulations. We use ab initio molecular dynamics...
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Jan 08, 2020
Mechanisms Underlying Motivational Dysfunction in Schizophrenia
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Mar 14, 2020
INTRODUCTION:The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. OBJECTIVE:To test if abnormal birth...
Published by: BMJ open diabetes research & care
Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with...
Who is prescribed valproate and how carefully is this treatment reviewed in UK mental health services? Data from a clinical audit.
BACKGROUND: The licensed indications for valproate are narrow, yet this medication is commonly prescribed in mental health services. OBJECTIVES: To explore the target symptoms/behaviours for which valproate is prescribed and how...
Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness
Shanquan Chen, Emilio Fernandez-Egea, Peter B Jones, Jonathan R Lewis, Rudolf N Cardinal
Jan 07, 2022
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with...
Birth weight, family history of diabetes and diabetes onset in schizophrenia
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Feb 10, 2020
Introduction: The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. Objective: To test if abnormal...
Causes of death in clozapine-treated patients in a catchment area
Emily Rose, Shanquan Chen, Concha Turrion, Christopher Jenkins, Rudolf N Cardinal, Emilio Fernandez-Egea
May 26, 2020
Optimal finite-range atomic basis sets for liquid water and ice.
Finite-range numerical atomic orbitals are the basis functions of choice for several first principles methods, due to their flexibility and scalability. Generating and testing such basis sets, however, remains a significant...
A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD.
Marjan Biria, Fiona-Xiaofei Huang, Yulia Worbe, Naomi A Fineberg, Trevor W Robbins, Emilio Fernandez-Egea
Jun 17, 2019
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